Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway

Dai, Xinglong; Li, Jianjun; Guo, Xiong; Cheng, Anqi; Deng, Xiaoya; Guo, Liqun; Wang, Ziwei

doi:10.1042/cs20191043

Cited by 23 publications

(16 citation statements)

References 29 publications

(22 reference statements)

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“…Furthermore, Ouyang et al ( 30 ) demonstrated that loss of androgen receptors promoted HCC invasion and metastasis via activating the circ-leucyl and cystinyl aminopeptidase/miR-532-3p/ras-related protein rab-9a signaling pathway under hypoxia. In addition, Dai et al ( 33 ) reported that circ-FYVE, RhoGEF and PH domain containing 4 attenuated gastric cancer progression via modulating the miR-532-3p/adenomatous polyposis coli/β-catenin signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Knockdown of circNRIP1 sensitizes colorectal cancer to 5‑FU via sponging miR‑532‑3p

Liu

Zhang

et al. 2021

Oncol Rep

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The present study aimed to investigate the influence of circular RNA nuclear receptor-interacting protein 1 (circNRIP1) on the chemotherapeutic effect of 5-fluorouracil (5-FU) in colorectal cancer (CRC) and reveal its potential molecular mechanisms. The effects of circNRIP1 on cell proliferation, migration and invasion, and apoptosis were evaluated using Cell Counting Kit-8, Transwell and flow cytometric assays, respectively. A dual-luciferase reporter assay was performed to verify the potential interaction between circNRIP1 and microRNA (miR)-532-3p. The results of the present study indicated that circNRIP1 was upregulated in CRC and its increased expression was associated with CRC progression. Furthermore, overexpression of circNRIP1 promoted CRC cell proliferation, invasion and migration, while it inhibited apoptosis. Knockdown of circNRIP1 significantly enhanced the 5-FU-induced inhibition of the viability of HCT116 and SW480 cells. Bioinformatics analysis predicted that miR-532-3p was a direct target of circNRIP1, which was further confirmed by a dual-luciferase reporter assay. miR-532-3p silencing reversed the effects of circNRIP1 knockdown on the sensitivity of 5-FU in the chemotherapy of CRC. The results suggested that circNRIP1 and miR-532-3p may be utilized to improve the diagnosis of CRC and serve as diagnostic markers. In conclusion, overexpression of circNRIP1 promoted the progression of CRC, while circNRIP1 silencing sensitized CRC cells to 5-FU via sponging miR-532-3p.

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Section: Discussionmentioning

confidence: 99%

Knockdown of circNRIP1 sensitizes colorectal cancer to 5‑FU via sponging miR‑532‑3p

Liu

Zhang

et al. 2021

Oncol Rep

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“…The circ_009361/miR-582-3p/ APC2 axis is further validated by the fact that in the absence of circ_009361, miR-582-3p targets the mRNA APC2 and inhibits its expression [ 59 ]. Interestingly, the targeting of APC2 and APC by circRNAs has also been observed in osteosarcoma and gastric cancer, with a similar impact on cancer cell growth [ 52 , 61 ].…”

Section: Circrna-mediated Regulation Of Major Signaling Pathwaysmentioning

confidence: 99%

Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression

Papatsirou

Artemaki

Karousi

et al. 2021

Cancers

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Signal transduction is an essential process that regulates and coordinates fundamental cellular processes, such as development, immunity, energy metabolism, and apoptosis. Through signaling, cells are capable of perceiving their environment and adjusting to changes, and most signaling cascades ultimately lead to alterations in gene expression. Circular RNAs (circRNAs) constitute an emerging type of endogenous transcripts with regulatory roles and unique properties. They are stable and expressed in a tissue-, cell-, and developmental stage-specific manner, while they are involved in the pathogenesis of several diseases, including cancer. Aberrantly expressed circRNAs can mediate cancer progression through regulation of the activity of major signaling cascades, such as the VEGF, WNT/β-catenin, MAPK, PI3K/AKT, and Notch signaling pathways, as well as by interfering with signaling crosstalk. Deregulated signaling can then function to induce angiogenesis, promote invasion, migration, and metastasis, and, generally, modulate the hallmarks of cancer. In this review article, we summarize the most recently described and intriguing cases of circRNA-mediated signaling regulation that are involved in cancer progression, and discuss the biomarker potential of circRNAs, as well as future therapeutic applications.

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“…In contrast, Dai et al found that miR-532-3p was overexpressed in GC tissues compared to non-cancerous tissues and might be involved in regulation of APC/ B-catenin signaling (99).…”

Section: Mir-532-3pmentioning

confidence: 89%

Vitamin D modulation and microRNAs in gastric cancer: prognostic and therapeutic role

Martín¹,

Castiñeiras²

2021

Transl Cancer Res TCR

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Gastric adenocarcinoma arises after a complex interaction between the host and environmental factors. Tumor location and TNM are the tools that currently guide treatment decisions. Surgery is the only curative treatment, but relapse is common. After relapse or advanced staged disease survival is poor and systemic treatment has modestly improved survival. An association between sun exposure, vitamin D status and gastric cancer (GC) incidence and mortality has been reported. The molecular differences of the histological subtypes and the new molecular classifications account for the great heterogeneity of this disease and are the basis for the discovery of new therapeutic targets. New prognostic and predictive factors are essential and microRNAs (miRNAs) are endogenous small non-coding RNA molecules with a great potential for diagnosis, prognosis and treatment of cancer. There are hundreds of miRNAs with altered expression in tumor gastric tissue when compared to normal gastric tissue. Many of these miRNAs are associated with clinicopathological variables and survival in patients with GC. Furthermore, the expression of some of these miRNAs with prognostic importance in CG is influenced by vitamin D and others are mediators of some of the actions of this vitamin. This review aims to update the evidence on several miRNAs with prognostic value and therapeutic potential in GC, whose expression may be influenced by vitamin D or may regulate vitamin D signaling.

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Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway

Cited by 23 publications

References 29 publications

Knockdown of circNRIP1 sensitizes colorectal cancer to 5‑FU via sponging miR‑532‑3p

Knockdown of circNRIP1 sensitizes colorectal cancer to 5‑FU via sponging miR‑532‑3p

Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression

Vitamin D modulation and microRNAs in gastric cancer: prognostic and therapeutic role

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