Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR‐218

Xu, Bojin; Wang, Qianqian; Li, Wenyi; Xia, Lili; Ge, Xin; Shen, Lisha; Cang, Zhen; Peng, Wenfang; Shao, Kan; Huang, Shan

doi:10.1111/jcmm.16129

Cited by 32 publications

(13 citation statements)

References 23 publications

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“…Furthermore, we revealed the adsorption relationship between circITSN2 and miR-218-5p. It is reported that miR-218-5p could be absorbed and regulated by many circRNAs, like circEIF4G2 (Lin et al, 2020;Xu et al, 2020) and circSAMD4A (Wei et al, 2020). Our research also identified a novel upstream circRNA sponge for miR-218-5p in chicken muscle development.…”

Section: Discussionsupporting

confidence: 54%

A Novel Circular RNA circITSN2 Targets the miR-218-5p/LMO7 Axis to Promote Chicken Embryonic Myoblast Proliferation and Differentiation

Shen

Wei

Liu

et al. 2021

Front. Cell Dev. Biol.

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Circular RNA (circRNA) is a class of endogenous non-coding RNAs without 5′ and 3′ ends; an increasing number of studies show that circRNA is involved in skeletal muscle development. From our previous sequencing data, the circRNAome in breast muscle of two chicken lines with a distinct rate of muscle development, which included a fast muscle growing broiler (FMGB) and a slow muscle growing layer (SMGL), we found a novel differentially expressed circRNA generated by intersectin 2 (ITSN2) gene (named circITSN2). We verified that circITSN2 is a skeletal muscle-enriched circRNA that promotes chicken primary myoblast (CPM) proliferation and differentiation. Further molecular mechanism analysis of circITSN2 in chicken myogenesis was performed, and we found circITSN2 directly targeting miR-218-5p. Besides, miR-218-5p inhibits CPM proliferation and differentiation, which is contrary to circITSN2. Commonly, circRNAs act as a miRNA sponge to alleviate the inhibition of miRNAs on mRNAs. Thus, we also identified that a downstream gene LIM domain 7 (LMO7) was inhibited by miR-218-5p, while circITSN2 could block the inhibitory effect of miR-218-5p by targeting it. Functional analysis revealed that LMO7 also accelerates CPM proliferation and differentiation, which was similar to circITSN2 but contrary to miR-218-5p. Taken together, these results suggested that circITSN2 promotes chicken embryonic skeletal muscle development via relieving the inhibition of miR-218-5p on LMO7. Our findings revealed a novel circITSN2/miR-218-5p/LMO7 axis in chicken embryonic skeletal muscle development, which expands our understanding of the complex muscle development regulatory network.

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Section: Discussionsupporting

confidence: 54%

A Novel Circular RNA circITSN2 Targets the miR-218-5p/LMO7 Axis to Promote Chicken Embryonic Myoblast Proliferation and Differentiation

Shen

Wei

Liu

et al. 2021

Front. Cell Dev. Biol.

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“…28 , 29 , 30 , 31 , 32 Growing evidence suggested that circRNAs play crucial roles in cell functions such as cell metabolism, differentiation, proliferation, apoptosis and invasion. 19 , 33 , 34 , 35 , 36 Increasing studies showed that circRNAs involved in the development of many diseases including cancers, neurological diseases, congenital diseases, intervertebral disc degeneration and endocrine diseases. 37 , 38 , 39 , 40 , 41 , 42 , 43 Recently, studies indicated that circRNAs also play important roles in osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Emerging roles of circular RNAs in osteoporosis

Chen

Zhang

Chang

2021

J Cellular Molecular Medi

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Osteoporosis is one bone disease characterized with skeletal impairment, bone strength reduced and fracture risk enhanced. [1][2][3][4] It is accompanied or asymptomatic by mild or serious symptoms, which is one cause of pathological fracture and also the high-risk factor influencing human health. [5][6][7] The incidence of osteoporosis is 70% in people over 80 years and 15% in people over 50 years old. 8,9 The osteoporosis patient's number exceeds 200 million worldwide at present, while the number may increase to 300 million as ageing population by 2023. 10 The modulation processes of bone metabolism are associated with several factors such as mechanical stimulation, epigenetic regulation and hormones. [11][12][13][14][15] The major therapies of osteoporosis are drug therapy and surgery, while the curative effect remains unsatisfactory. [16][17][18] Thus, it is crucial to find new biomarkers for the indention and therapy of osteoporosis.Circular RNAs (circRNAs) are formed by reverse splicing of splice accepter at 5′ end splice donor at the 3′ end in the pre-mRNA. [19][20][21][22] cir-cRNAs are one group of noncoding RNA and temporal, disease specific and spatial are expressed in several tissues and cells and can be acted as therapeutic targets and biomarkers. [23][24][25][26] Although circRNAs are mostly located in cytoplasm, some circRNAs containing introns are originated from nucleus. 27 CircRNAs have several functions including regulating gene transcription, regulating translation, modulating alternative splicing, functioning as miRNA sponges and interacting with RBPs (RNAbinding proteins). [28][29][30][31][32] Growing evidence suggested that circRNAs play crucial roles in cell functions such as cell metabolism, differentiation, proliferation, apoptosis and invasion. 19,[33][34][35][36] Increasing studies showed that circRNAs involved in the development of many diseases including cancers, neurological diseases, congenital diseases, intervertebral disc degeneration and endocrine diseases. [37][38][39][40][41][42][43] Recently, studies indicated that circRNAs also play important roles in osteoporosis. 44

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“…Danshen is a very valuable herb in Chinese traditional medicine. It has been reported that Danshen has the antioxidant, anti-inflammatory and antibacterial activities 53 . The anti-inflammation efficacy of Danshen is generally played by the main biological activities in it, such as Salvianolic acid B, tanshinone IIA, Danshensu and dihydrotanshinone I 54 .…”

Section: Discussionmentioning

confidence: 99%

Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice

et al. 2021

Sci Rep

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With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in the world. Although many immunosuppressant and biological drugs have been used for UC treatment, the cure rate is still very low. It is necessary to find some safe and long-term used medicine for UC cure. Recently, the Chinese traditional herb Danshen has been investigated in the treatment of UC. However, it is a limitation of Danshen that many of the active components in Danshen are not easily absorbed by the human body. Probiotics could convert macromolecules into smaller molecules to facilitate absorption. Thus, Lactobacillus rhamnosus (F-B4-1) and Bacillus subtillis Natto (F-A7-1) were screened to ferment Danshen in this study. The fermented Danshen products were gavaged in the dextran sulfate sodium (DSS)-induced UC model mice. Danshen had better results to attenuate symptoms of DSS-induced UC after fermented with F-B4-1 and F-A7-1. Loss of body weight and disease activity index (DAI) were reduced. The abnormally short colon lengths and colonic damage were recovered. And fermented Danshen had the better inhibitory effect than Danshen itself on pro-inflammatory cytokine expression during DSS-induced UC. The results indicated that compared with Danshen, fermented Danshen relieved DSS-induced UC in mice more effectively. Danshen fermented by probiotics might be an effective treatment to UC in clinic stage in the future.

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Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR‐218

Cited by 32 publications

References 23 publications

A Novel Circular RNA circITSN2 Targets the miR-218-5p/LMO7 Axis to Promote Chicken Embryonic Myoblast Proliferation and Differentiation

A Novel Circular RNA circITSN2 Targets the miR-218-5p/LMO7 Axis to Promote Chicken Embryonic Myoblast Proliferation and Differentiation

Emerging roles of circular RNAs in osteoporosis

Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice

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