Circular RNA circABCC4 regulates lung adenocarcinoma progression via miR‐3186‐3p/TNRC6B axis

Liu, Meijuan; Wang, Pengwei; Sui, Xiaomei; Ding, Fang; Liu, Li; Gao, Zeng‐Yan; Cheng, Zhaozhong

doi:10.1002/jcb.29627

Cited by 15 publications

(14 citation statements)

References 30 publications

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“…For example, circ_0013958 expression was positively correlated with lymphatic metastasis of LUAD patients [ 26 ]; a negative association between circCRIM1 and lymphatic metastasis and TNM stage of LUAD was verified [ 27 ]. Additionally, increasing evidence has demonstrated the functional roles of circRNAs in the progression of LUAD [ 13 , 14 , 28 ]. circXPO1 was responsible for LUAD progression and might be a therapeutic target for this disease [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Sponging miRNAs, which results in inhibition of target miRNA expression and subsequent enhancing levels of miRNA-targeted genes has been considered to be the main regulatory mechanism of circRNAs[ 12 ]. Increasing studies have revealed that circRNAs play crucial roles in affecting the malignant phenotypes of LUAD, including growth and metastasis[ 13 , 14 ]. A recent research by Feng et al suggested that hsa-circ-0000211 drove the migration and invasion of LUAD cells via enhancing HIF1-α expression by sequestering miR-622[ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

et al. 2021

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Background Lung adenocarcinoma (LUAD) is a common subtype of lung cancer with high recurrence rate and fatality. Circ_0001361 has been recognized as key regulators in various malignancies, but its roles in LUAD remain ambiguous. Methods Circ_0001361, miR-525-5p, and VMA21 levels were assessed by RT-qPCR. The growth and metastasis of LUAD cells were detected by MTT, colony formation, wound scratch, and transwell assays, respectively. The interaction between circ_0001361/VMA21 and miR-525-5p was detected by dual luciferase, RNA immunoprecipitation, and RNA pull-down assays. VMA21 protein level was detected by Western blotting. Nude mouse xenograft model was established to determine the role of circ_0001361 in tumor growth in vivo. Results Circ_0001361 was up-regulated, while miR-525-5p was down-regulated in LUAD tissues and cells. Functional experiments demonstrated that circ_0001361 drove LUAD cell growth and metastasis. Mechanistically, circ_0001361 functioned as a sponge of miR-525-5p to up-regulate downstream target VMA21 level. MiR-525-5p/VMA21 axis was involved in circ_0001361-mediated malignant phenotypes of LUAD cells. Finally, inhibition of circ_0001361 restrained in vivo xenograft tumor growth via regulating miR-525-5p/VMA21 axis. Conclusion Our findings elucidate that circ_0001361 facilitates the tumorigenesis and development of LUAD through miR-525-5p/VMA21 axis, providing evidence for circ_0001361 as a potential prognosis biomarker and therapeutic target for clinical treatment of LUAD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

et al. 2021

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“…The circRNAs, circABCC4 and circ0006916, were shown to interact with TNRC6 to positively and negatively regulate lung cancer progression, respectively. CircABCC4 was upregulated in LUAD and promoted cell proliferation, migration and invasion via miR-3186-3p sponging to upregulate TNRC6B ( 72 ). However, Circ0006910 was downregulated in lung cancer cells and tissue, and acted as a tumor suppressor in NSCLC via miR-522-3p sponging, and inhibiting pleckstrin homology domain and leucine rich repeat protein phosphatase 1 (PHLPP1) activity, thus inhibiting cell proliferation ( 73 ).…”

Section: The Role Of Circrnas In Lung Cancermentioning

confidence: 99%

Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives

Chen

Zhang

et al. 2021

Front. Oncol.

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Globally, lung cancer is the most commonly diagnosed cancer and carries with it the greatest mortality rate, with 5-year survival rates varying from 4–17% depending on stage and geographical differences. For decades, researchers have studied disease mechanisms, occurrence rates and disease development, however, the mechanisms underlying disease progression are not yet fully elucidated, thus an increased understanding of disease pathogenesis is key to developing new strategies towards specific disease diagnoses and targeted treatments. Circular RNAs (circRNAs) are a class of non-coding RNA widely expressed in eukaryotic cells, and participate in various biological processes implicated in human disease. Recent studies have indicated that circRNAs both positively and negatively regulate lung cancer cell proliferation, migration, invasion and apoptosis. Additionally, circRNAs could be promising biomarkers and targets for lung cancer therapies. This review systematically highlights recent advances in circRNA regulatory roles in lung cancer, and sheds light on their use as potential biomarkers and treatment targets for this disease.

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“…Growing evidence suggests that circRNA can act as a miRNA sponge to mediate the expression of target mRNA [12]. Recently, it has been identified that several circRNAs participate in LUAD progression, such as circ-000032 [13], circ-PVT1 [14] and circ-ABCC4 [15]. Nevertheless, the function of most circRNAs in LUAD remains unknown.…”

Section: Introductionmentioning

confidence: 99%

circ-ANXA7 facilitates lung adenocarcinoma progression via miR-331/LAD1 axis

Wang

2021

Cancer Cell Int

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Background Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer, with a poor prognosis. The roles of circular RNAs (circRNAs) in tumors have been initially clarified. In this study, we probed into the functions and underlying molecular mechanisms of circ-ANXA7 in LUAD. Methods According to circRNA microarray analysis based on 40 pairs of LUAD tissues and non-tumor tissues, a novel circ-ANXA7 was up-regulated in LUAD, which was verified in LUAD tissues and cells by RT-qPCR. Correlation between its expression and clinical features of LUAD was analyzed. When transfected with sh-circ-ANXA7, proliferation, invasion, and migration of LUAD cells were determined by a series of functional assays. Furthermore, tumor growth was investigated in nude mice injected with sh-circ-ANXA7. Dual luciferase report and gain and loss assays were used to confirm the relationships between circ-ANXA7 and miR-331, miR-331 and LAD1. Results circ-ANXA7 was up-regulated in LUAD tissues and cells. Its high expression promoted proliferation, migration, and invasion of LUAD cells as well as tumor growth. High circ-ANXA7 expression usually predicted a poorer prognosis for LUAD patients. Furthermore, circ-ANXA7 could accelerate proliferation and invasion of LUAD cells by targeting miR-331. miR-331 directly bound to the 3′-UTR of LAD1. LAD1 induced proliferation and invasion of LUAD cells, which was reversed after co-transfection with circ-ANXA7 knockdown. LAD1 expression could be an independent prognostic marker for LUAD by univariate and multivariate analysis. Conclusions Our research identified a novel circ-ANXA7 for LUAD, which could facilitate proliferation, migration, and invasion of LUAD cells by miR-331/ LAD1 axis. circ-ANXA7 could become a promising prognosis and treatment target for LUAD.

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Circular RNA circABCC4 regulates lung adenocarcinoma progression via miR‐3186‐3p/TNRC6B axis

Cited by 15 publications

References 30 publications

Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis

Circular RNAs in Lung Cancer: Recent Advances and Future Perspectives

circ-ANXA7 facilitates lung adenocarcinoma progression via miR-331/LAD1 axis

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