Circular RNA circ_0011269 sponges miR‐122 to regulate RUNX2 expression and promotes osteoporosis progression

Xu, Xiao; Chen, Yuan; Tan, Bingyi; Wang, Dachuan; Yuan, Zenong; Wang, Feng

doi:10.1002/jcb.29709

Cited by 32 publications

(22 citation statements)

References 23 publications

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“…RUNX2, a key determinant of osteoblast differentiation and maturation (75), is broadly used as an osteogenic marker gene. Xu et al showed that the expressions of circ_0011269 and RUNX2 were both upregulated, while the expression of miR-122 was downregulated during the osteogenic process (45). A subsequent study showed that circ_0011269 sequestered miR-122 to regulate the expression level of RUNX2.…”

Section: Runxmentioning

confidence: 99%

Circular RNAs as potential regulators in bone remodeling: a narrative review

Pan¹,

Cen²,

Zhang³

et al. 2021

Ann Transl Med

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In this review, we focus on the recent progress of circular ribonucleic acids (circRNAs)-related molecular mechanisms in the processes of osteogenesis and osteoclastogenesis, and explore their roles in the development of bone-remodeling disorders.Background: The well-coupled bone-formation and bone-resorption processes are vital in bone remodeling. Once the balance is disrupted, bone-remodeling disorders (e.g., osteoporosis and osteopetrosis) occur, severely affecting patients' quality of life. CircRNAs, the newly discovered members of the noncoding RNA family, have been reported to act as key checkpoints of various signaling pathways that influence osteoblasts and osteoclasts functions, thus regulating the physiological and pathological processes of bone homeostasis.Methods: Three English and three Chinese databases [i.e., PubMed, Embase, MEDLINE (via Ovid), Chinese Biomedical Literature, China National Knowledge Infrastructure, and VIP databases] were searched to June 2021 without language restrictions. Studies exploring the roles of circRNAs in key bone remodeling mediators, such as Smad-dependent bone morphogenetic protein (BMP)/transforming growth factor beta (TGF-β), Wnts, runt-related transcription factor (RUNX), forkhead boxes (FOXs), colony-stimulating factor 1 (CSF-1), receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG), and circRNA-related bone-remodeling disorders, were included.Conclusions: Many circRNAs have been shown to promote osteogenesis and facilitate osteoclast differentiation via diverse mechanisms, and thus modulate the process of bone homeostasis. The imbalance or impairment of these two parts causes diseases, such as osteoporosis, and osteonecrosis of the femoral head, which are also closely correlated to the aberrant presence of circRNAs. Current evidence provides us with promising diagnosis and treatment methods for some bone homeostasis disorders.

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Section: Runxmentioning

confidence: 99%

Circular RNAs as potential regulators in bone remodeling: a narrative review

Pan¹,

Cen²,

Zhang³

et al. 2021

Ann Transl Med

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“…The majority of osteoporosis -related circRNAs are involved in regulating osteogenesis by sponging miRNAs and consequently regulating the expression or activity of downstream osteogenesis genes. Circ-RUNX2 88 , circ-VANGL1 89 , circ-0011269 90 , circ-0076906 91 , circRNA-0016624 92 , circ-0006393 93 , circRNA-0048211 94 , circ-SLC8A1 95 , circ-YAP1 96 and circ-0076690 97 are found down-regulated in osteoporosis and could enhance osteogenesis of BMSCs by sponging miRNAs and subsequently upregulating the expression and activities of osteogenetic genes (such as RUNX2, BMP2, OPN, OCN, OGN, FOXO1, APAK2 or ALP) ( Figure 4 A ). Exosomes of BMSCs (BMSCs-Exos) have also been shown to function in bone regeneration 98 - 100 , while exosomes-derived from circ-Rtn4 have been shown to promote osteogenesis by targeting miR-146a 101 .…”

Section: Circrnas and Osteoporosismentioning

confidence: 99%

Promising diagnostic and therapeutic circRNAs for skeletal and chondral disorders

Chen¹,

Tang²,

Wang³

et al. 2021

Int. J. Biol. Sci.

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Circular RNAs (circRNAs) belong to a highly conserved subtype of non-coding RNAs, produced by the back-splicing of specific regions of pre-mRNA. CircRNAs have wide-ranging effects on eukaryotic physiology and pathology by acting as transcription regulators, miRNA sponges, protein sponges, and templates for translation. Skeletal and chondral disorders are the leading causes of pain and disability, especially for elders, affecting hundreds of millions of people worldwide. Plenty of evidence have shown that circRNAs are dysregulated and play vital roles in the occurrence and progression of skeletal and chondral disorders. Herein, we systematically summarize the emerging roles and underlying molecular mechanisms of hub circRNAs in the pathogenesis of several representative skeletal and chondral disorders. Our findings may provide further insight into the mechanistic details of the role of circRNA in bone or cartilage metabolism, and highlight the promising application of circRNAs in serving as potential diagnostic or therapeutic targets for the prevention and treatment of skeletal and chondral disorders.

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“…mir-183-5p inhibits BMSC proliferation and bone formation, as well as promotes osteoclast differentiation in BM-derived macrophages via the co-oxygenase-1 (Ho1) target, suggesting that miR-183 by effect is involved in the absorption of both, in reducing age-related bone in absorption processes. 131 Vesicular miR-31 targets Fzd3, a Wnt5a receptor and prevents osteogenic differentiation. 132 miR-214, another age-related miRNA, is increased with age in bone.…”

Section: Mirnas In Opmentioning

confidence: 99%