Circular RNA circ_0000043 promotes endometrial carcinoma progression by regulating miR-1271-5p/CTNND1 axis

Wei, D. H.; Tian, Mei‐Rong; Fan, Weibo; Zhong, Xiaojing; Wang, Shuhong; Chen, Yahang; Zhang, Shihong

doi:10.1007/s00404-020-05849-z

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…Therefore, miR-1271-5p is also considered as a potential target for promoting chemosensitivity in cancers. Recently research revealed that miR-1271-5p had decreased expression in EC tissues, and it could hinder EC cell growth and metastasis [27]. Here, miR-1271-5p was confirmed to be underexpressed in PTX-resistant EC tissues and cells, and its overexpression enhanced the PTX sensitivity of EC cells through inhibiting cell growth and invasion.…”

Section: Discussionmentioning

confidence: 91%

Circ_0039569 contributes to the paclitaxel resistance of endometrial cancer via targeting miR-1271-5p/PHF6 pathway

Zhang

et al. 2022

Anti-Cancer Drugs

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Circular RNA (circRNA) has been confirmed to be involved in the chemoresistance process of cancers. However, whether circ_0039569 mediates the chemoresistance of endometrial cancer (EC) remains unclear. Quantitative real-time PCR was performed to analyze circ_0039569, microRNA (miR)-1271-5p and PHD finger protein 6 (PHF6) expression. Cell counting kit-8 assay was used to assess the paclitaxel (PTX) resistance of cells. Cell proliferation, apoptosis and invasion were determined using EdU assay, colony formation assay, flow cytometry and transwell assay. Protein expression was examined by western blot analysis. RNA interaction was verified by dual-luciferase reporter assay and RNA pull-down assay. Xenograft tumor models were constructed to explore the effect of circ_0039569 knockdown on the PTX sensitivity of EC tumors. Circ_0039569 was upregulated in PTX-resistant EC tissues and cells. Knockdown of circ_0039569 enhanced the PTX sensitivity of EC cells by inhibiting cell growth and invasion. MiR-1271-5p could be sponged by circ_0039569, and its inhibitor abolished the regulation of circ_0039569 knockdown on the PTX sensitivity of EC cells. PHF6 was targeted by miR-1271-5p, and its overexpression eliminated the promotion effect of miR-1271-5p on the PTX sensitivity of EC cells. Also, interference of circ_0036569 enhanced the PTX sensitivity of EC tumors by regulating the miR-1271-5p/PHF6 pathway. Collectively, circ_0039569 might contribute to the PTX resistance of EC through the regulation of the miR-1271-5p/PHF6 axis.

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Section: Discussionmentioning

confidence: 91%

Circ_0039569 contributes to the paclitaxel resistance of endometrial cancer via targeting miR-1271-5p/PHF6 pathway

Zhang

et al. 2022

Anti-Cancer Drugs

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“…Here, FISH, a luciferase reporter assay, and RT‐qPCR analysis indicated that circCASK exerted its function by sponging miR‐1271‐5p and thus forming the circCASK/miR‐1271‐5p regulatory axis. It has been reported that miR‐1271‐5p plays an important tumor‐suppressor role in several cancers, including liver, 15 prostate, 30 endometrial, 31 ovarian, 13 cervical, 32 and lung cancer 33 . More importantly, miR‐1271‐5p suppresses CRC carcinogenesis 34 .…”

Section: Discussionmentioning

confidence: 99%

FOXC2‐induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression

et al. 2023

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Colorectal cancer (CRC) ranks as the most common gastrointestinal solid carcinoma globally. Substantial evidence has established a pivotal role for circular RNAs (circRNAs) in CRC progression. In this study, differentially expressed cir-cRNAs were analyzed based on a public dataset (GSE126094) and elevated expression of circCASK (hsa_circ_0001917) was validated in CRC. Moreover, increased circCASK was also confirmed in CRC patients. Functionally, circCASK knockdown led to a significant decrease in CRC cell growth and attenuated cell migration and invasion. Similarly, circCASK knockdown markedly attenuated tumor growth in vivo. Mechanistically, circCASK sponged miR-1271-5p and enhanced sine oculis homeobox homolog 1 (SIX1) expression. More importantly, both SIX1 overexpression and miR-1271-5p knockdown could reverse the cellular behavior inhibition induced by circCASK knockdown. Furthermore, SIX1 was most strongly and positively linked with Wnt/β-catenin signaling pathways, cir-cCASK triggered Wnt/β-catenin signaling through the miR-1271-5p/SIX1 axis, and FOXC2 transcriptionally induced circCASK expression. In conclusion, cir-cCASK induced by FOXC2 accelerated CRC progression through the miR-1271-5p/SIX1 axis, thus providing an interesting insight into CRC tumorigenesis.

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“…A recent review by Hutt et al[ 57 ] described numerous miRNAs with diagnostic potential for EC [ 58 , 59 ] and for circular RNAs are said to provide new insights for EC treatment [ 60 ]. The decreased miR-200c blood levels in our cancer patients were described for hepatic cellular cancer tissue, and its potential as a prognostic marker or even as a therapeutic target discussed [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study

Schuhn

Tobar

Gahlawat

et al. 2022

Arch Gynecol Obstet

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Purpose Endometrial carcinoma is the second most common gynecological malignancy. Until today lacking a screening tool. A blood-based biomarker could help address this need. Methods The expression levels of 30 acylcarnitines, 18 amino acids, 6 miRNAs, and 7 DNA methylation sites were measured in blood samples from 331 women (20 EC, 14 benign uterine lesions (benign), 140 breast cancers (BC), 157 controls). Areas under the ROC curves (AUC), sensitivity (sens.) and specificity (spec.) were computed to identify the variables best distinguishing. Results The best top ten markers for the four comparisons (cancer vs. cancer-free; EC vs. BC, EC vs. controls; EC vs. benign), were identified via AUC. Malonylcarnitine distinguished best patients with EC from controls (AUC: 0.827, sens. 80%, spec. 73.1%) or BC (AUC: 0.819, sens. 84.3%, spec. 80%) being most notable. Tryptophan best differentiated benign from EC (AUC: 0.846, sens. 70%, spec. 92.9%). Conclusions The levels of the analyzed blood markers yielded promising results in the detection of EC and warrant further evaluation.

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Circular RNA circ_0000043 promotes endometrial carcinoma progression by regulating miR-1271-5p/CTNND1 axis

Cited by 11 publications

References 27 publications

Circ_0039569 contributes to the paclitaxel resistance of endometrial cancer via targeting miR-1271-5p/PHF6 pathway

Circ_0039569 contributes to the paclitaxel resistance of endometrial cancer via targeting miR-1271-5p/PHF6 pathway

FOXC2‐induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression

Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study

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