Circular RNA atlas in osteoclast differentiation with and without alendronate treatment

Lin, Jianbiao; Ma, Shaofeng; Zhu, Cong; Chen, Chang; Lin, Wei-Jen; Lin, Cheng-Yuan; Huang, Guofeng; Ding, Zhenqi

doi:10.1186/s13018-020-01722-6

Cited by 11 publications

(10 citation statements)

References 35 publications

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“…Moreover, they showed that circ_0057340 and circ_0134944 were overexpressed and circ_0005692, circ_0088422 and circ_0076906 were decreased in osteoporosis group by qRT-PCR analysis. Lin et al 50 have studied the circRNAs expression profiling in the osteoclast differentiation without and with alendronate treatment. There were 1394 circRNAs were upregulated and 214 circRNAs were downregulated in the osteoclast (OC) precursors (OPCSs) groups compared to OC group.…”

Section: Circrna E Xpre Ss Ion Profiling and Integ R Ative Analys Is In Scimentioning

confidence: 99%

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Emerging roles of circular RNAs in osteoporosis

Chen

Zhang

Chang

2021

J Cellular Molecular Medi

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Osteoporosis is one bone disease characterized with skeletal impairment, bone strength reduced and fracture risk enhanced. [1][2][3][4] It is accompanied or asymptomatic by mild or serious symptoms, which is one cause of pathological fracture and also the high-risk factor influencing human health. [5][6][7] The incidence of osteoporosis is 70% in people over 80 years and 15% in people over 50 years old. 8,9 The osteoporosis patient's number exceeds 200 million worldwide at present, while the number may increase to 300 million as ageing population by 2023. 10 The modulation processes of bone metabolism are associated with several factors such as mechanical stimulation, epigenetic regulation and hormones. [11][12][13][14][15] The major therapies of osteoporosis are drug therapy and surgery, while the curative effect remains unsatisfactory. [16][17][18] Thus, it is crucial to find new biomarkers for the indention and therapy of osteoporosis.Circular RNAs (circRNAs) are formed by reverse splicing of splice accepter at 5′ end splice donor at the 3′ end in the pre-mRNA. [19][20][21][22] cir-cRNAs are one group of noncoding RNA and temporal, disease specific and spatial are expressed in several tissues and cells and can be acted as therapeutic targets and biomarkers. [23][24][25][26] Although circRNAs are mostly located in cytoplasm, some circRNAs containing introns are originated from nucleus. 27 CircRNAs have several functions including regulating gene transcription, regulating translation, modulating alternative splicing, functioning as miRNA sponges and interacting with RBPs (RNAbinding proteins). [28][29][30][31][32] Growing evidence suggested that circRNAs play crucial roles in cell functions such as cell metabolism, differentiation, proliferation, apoptosis and invasion. 19,[33][34][35][36] Increasing studies showed that circRNAs involved in the development of many diseases including cancers, neurological diseases, congenital diseases, intervertebral disc degeneration and endocrine diseases. [37][38][39][40][41][42][43] Recently, studies indicated that circRNAs also play important roles in osteoporosis. 44

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Section: Circrna E Xpre Ss Ion Profiling and Integ R Ative Analys Is In Scimentioning

confidence: 99%

“…Lin et al 50 have studied the circRNAs expression profiling in the osteoclast differentiation without and with alendronate treatment. There were 1394 circRNAs were upregulated and 214 circRNAs were downregulated in the osteoclast (OC) precursors (OPCSs) groups compared to OC group.…”

Section: Circrna Expression Profiling and Integrative Analysis In Scimentioning

confidence: 99%

Emerging roles of circular RNAs in osteoporosis

Chen

Zhang

Chang

2021

J Cellular Molecular Medi

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“…Finally, Lin et al [24] evaluating the expression profile of circRNAs during osteoclast differentiation in the presence or absence of alendronate, discovered 110 DECs between osteoclast precursors (OPCSs) with respect to osteoclasts (OCs) and alendronate-treated OCs, and found that circ_0001776, circ_0000284, circ_0002922, circ_0000638, circ_0000994, circ_0007710 and circ_0113954 were upregulated in OCs compared to OPCSs.…”

Section: Expression Of Circrnas In Op: the First Studiesmentioning

confidence: 99%

The possible use of circRNAs as useful diagnostic, prognostic and therapeutic biomarkers in osteoporosis

et al. 2022

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Bone health is ensured by coordinated work between osteoclasts and osteoblasts. When this balance is lacking, skeletal diseases, including osteoporosis (OP), arise. The latter is caused by an increase in erosion and a decrease in bone matrix deposition, resulting in low-quality bone that tends to have a higher risk of fracture. To date, despite the use of sophisticated software to diagnose OP, and the use of several drugs to mitigate the effects of this pathology, there are still limitations that drive the scientific community to search for new biomarkers. In recent years, epigenetics has attracted the attention of many researchers as a possible mechanism involved in the onset and progression of OP. In particular they have focused on circular RNAs (circRNAs), a particular class of non-coding RNAs. Precisely because of their properties, these molecules could open up new possibilities in the field of precision medicine. In conclusion, therefore, the aim of this review is to offer an overview on circRNAs, which could potentially become, in the future, useful diagnostic, prognostic and therapeutic biomarkers in OP routine clinical practice.

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“…Research has shown that the differentiation process of osteoclasts is regulated by the relative expression level of RANKL/OPG, and diverse agents cross-talking with these two ligands could affect this process (99). For example, circRNAs related to osteoclast differentiation were selected to construct a circRNA-miRNA-mRNA network (90). Among the modulated mRNAs, NF-κB1, and TRAF6, which are indispensable mediators of the RANK/RANKL pathway, were predicted to be targeted by upstream miRNAs and circRNAs.…”

Section: Rankl/opgmentioning

confidence: 99%

Circular RNAs as potential regulators in bone remodeling: a narrative review

Pan¹,

Cen²,

Zhang³

et al. 2021

Ann Transl Med

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In this review, we focus on the recent progress of circular ribonucleic acids (circRNAs)-related molecular mechanisms in the processes of osteogenesis and osteoclastogenesis, and explore their roles in the development of bone-remodeling disorders.Background: The well-coupled bone-formation and bone-resorption processes are vital in bone remodeling. Once the balance is disrupted, bone-remodeling disorders (e.g., osteoporosis and osteopetrosis) occur, severely affecting patients' quality of life. CircRNAs, the newly discovered members of the noncoding RNA family, have been reported to act as key checkpoints of various signaling pathways that influence osteoblasts and osteoclasts functions, thus regulating the physiological and pathological processes of bone homeostasis.Methods: Three English and three Chinese databases [i.e., PubMed, Embase, MEDLINE (via Ovid), Chinese Biomedical Literature, China National Knowledge Infrastructure, and VIP databases] were searched to June 2021 without language restrictions. Studies exploring the roles of circRNAs in key bone remodeling mediators, such as Smad-dependent bone morphogenetic protein (BMP)/transforming growth factor beta (TGF-β), Wnts, runt-related transcription factor (RUNX), forkhead boxes (FOXs), colony-stimulating factor 1 (CSF-1), receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG), and circRNA-related bone-remodeling disorders, were included.Conclusions: Many circRNAs have been shown to promote osteogenesis and facilitate osteoclast differentiation via diverse mechanisms, and thus modulate the process of bone homeostasis. The imbalance or impairment of these two parts causes diseases, such as osteoporosis, and osteonecrosis of the femoral head, which are also closely correlated to the aberrant presence of circRNAs. Current evidence provides us with promising diagnosis and treatment methods for some bone homeostasis disorders.

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Circular RNA atlas in osteoclast differentiation with and without alendronate treatment

Cited by 11 publications

References 35 publications

Emerging roles of circular RNAs in osteoporosis

Emerging roles of circular RNAs in osteoporosis

The possible use of circRNAs as useful diagnostic, prognostic and therapeutic biomarkers in osteoporosis

Circular RNAs as potential regulators in bone remodeling: a narrative review

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