Circular RNA‐associated ceRNA network involved in HIF‐1 signalling in triple‐negative breast cancer: circ_0047303 as a potential key regulator

Darbeheshti, Farzaneh; Mahdiannasser, Mojdeh; Noroozi, Zahra; Firoozi, Zahra; Mansoori, Behnam; Daraei, Abdolreza; Bastami, Milad; Nariman‐Saleh‐Fam, Ziba; Valipour, Elahe; Mansoori, Yaser

doi:10.1111/jcmm.17066

Cited by 15 publications

(13 citation statements)

References 46 publications

(58 reference statements)

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“…CircRNAs can act (i) by sponging the effect of microRNAs (miRNAs) ( 9 , 10 ); (ii) by regulating gene expression at the transcriptional and posttranscriptional levels through various mechanisms ( 11 , 12 ); (iii) and eventually as a coding template through a cap-independent translation mechanism ( 13 ). Aberrant circRNA expression has been identified as a hallmark of cancer ( 14 – 16 ).…”

Section: Introductionmentioning

confidence: 99%

Marek’s Disease Virus Virulence Genes Encode Circular RNAs

Chasseur

Trozzi

Istasse

et al. 2022

J Virol

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Section: Introductionmentioning

confidence: 99%

Marek’s Disease Virus Virulence Genes Encode Circular RNAs

Chasseur

Trozzi

Istasse

et al. 2022

J Virol

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“…It is suggested that the down expression of lncRNA-LET might contribute to the estrogen-related tumorigenic mechanism. Growing evidence indicates that the crosstalk among different RNAs (coding and non-coding) at the molecular levels underlies the regulation of gene expression and consequently determines cell functions [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNAs-LET Behave as a Noncoding Signature for Early-Onset Menarche and Late-Onset Menopause in Breast Cancer Patients

Darbeheshti

Abdollahzadeh

Dastsooz

et al. 2021

GMJ

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Background: Breast cancer (BC) as a major cause of cancer-related death in women shows a very complex molecular and clinical phenotype, which has reduced the effectiveness of medical interventions. Evidence suggests that long noncoding RNAs (lncRNAs) are responsible for an important part of this complexity. This study aims to assess the expression and clinical implication of lncRNA LET in the pathobiology of BC. Materials and Methods: Quantitative real-time polymerase chain reaction was used to measure the expression of lncRNA-LET in breast tumors and adjacent normal-appearing tissues from 4 BC patients, as well as normal mammary tissues. Moreover, a bioinformatics approach was applied to uncover the potential lncRNA-LET-mediated sponge regulatory network as LET/miRNA/mRNA crosstalk. Results: Our study revealed that lncRNA-LET was significantly down-expressed not only in breast tumors but also in normal appearing breast tissues samples from BC subjects compared with true normal breast tissues obtained from healthy women. The low level of lncRNA-LET was meaningfully associated with early-onset menarche (≤13 years) and late-onset menopause (≥50) in patients. Moreover, the bioinformatics analyses support that lncRNA-LET could function as a tumor suppressor miRNA sponge. Conclusion: The results indicate that normal appearing breast tissues can undergo tumor-related molecular changes. Furthermore, they reveal the potential role of the dysregulation in LET-mediated ceRNA network in the pathophysiology of BC.

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“…There are many circRNAs that can regulate EMT and metastasis and further contribute to the carcinogenic process, and the circular RNA-associated ceRNA network involved in biological processes may be quite crucial in the occurrence and development of cancer. For example, circ_0047303 may be a potential key regulator to mediate the upregulation of key angiogenesis-related genes, including HIF-1, EIF4E2, and VEGFA in TNBC, via sponging the tumor-suppressive miRNAs [64], circ_0000518 promotes breast cancer progression through the miRNA-1225-3p/SRY-box transcription factor 4 pathway, and it is oncogenic in BC [65], circ_0089153 is an oncogene in breast cancer, which enhances proliferation and metastasis via sponging miR-2467-3p/E2F6 [66], circ_IRAK3 exerts a promoting effect on BC progression by modulating the miR-603/KIF2A axis [67], circRNA_000554 up-regulates ZFP36 by sponging miR-182 [68], circ_RPPH1 up-regulates ARHGAP1 via sponging miR-542-3p [69], circ_ZFR up-regulates FABP7 by sponging miR-223-3p [70]. Hsa-circ-0061825 (circ-TFF1) contributes to BC via targeting miR-326/TFF1 [71], and circ-NOT2 can prevent breast cancer invasion, migration and EMT by regulating twist family BHLH transcription factor via targeting miR-409-3p/Twist1 [72].…”

Section: Circrna-associated Cerna Network In Breast Cancermentioning

confidence: 99%

Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

Guo

Jia

Luo

et al. 2022

IJMS

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Circular RNAs (circRNAs), a class of new endogenous non-coding RNAs (ncRNAs), are closely related to the carcinogenic process and play a critical role in tumor metastasis. CircRNAs can lay the foundation for tumor metastasis via promoting tumor angiogenesis, make tumor cells gain the ability of migration and invasion by regulating epithelial-mesenchymal transition (EMT), interact with immune cells, cytokines, chemokines, and other non-cellular components in the tumor microenvironment, damage the normal immune function or escape the immunosuppressive network, and further promote cell survival and metastasis. Herein, based on the characteristics and biological functions of circRNA, we elaborated on the effect of circRNA via circRNA-associated competing endogenous RNA (ceRNA) network by acting as miRNA/isomiR sponges on tumor angiogenesis, cancer cell migration and invasion, and interaction with the tumor microenvironment (TME), then explored the potential interactions across different RNAs, and finally discussed the potential clinical value and application as a promising biomarker. These results provide a theoretical basis for the further application of metastasis-related circRNAs in cancer treatment. In summary, we briefly summarize the diverse roles of a circRNA-associated ceRNA network in cancer metastasis and the potential clinical application, especially the interaction of circRNA and miRNA/isomiR, which may complicate the RNA regulatory network and which will contribute to a novel insight into circRNA in the future.

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Circular RNA‐associated ceRNA network involved in HIF‐1 signalling in triple‐negative breast cancer: circ_0047303 as a potential key regulator

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 15 publications

References 46 publications

Marek’s Disease Virus Virulence Genes Encode Circular RNAs

Marek’s Disease Virus Virulence Genes Encode Circular RNAs

Long Noncoding RNAs-LET Behave as a Noncoding Signature for Early-Onset Menarche and Late-Onset Menopause in Breast Cancer Patients

Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

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