Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

Zhang, Yue; Zhang, Xinyi; Xu, Yumeng; Fang, Shikun; Ji, Ying; Lü, Ling; Xu, Wenrong; Qian, Hui; Zhao, Liang

doi:10.3389/fonc.2022.845703

Cited by 11 publications

(10 citation statements)

References 222 publications

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“…Non-coding RNAs accounted for approximately 60% of the transcriptional output of human cells and had been shown to regulate a variety of cellular processes under physiological and pathological conditions ( 13 , 52 ). RNA polymerase II was also required by cancer-related genes in eukaryotes nucleus to produce non-coding RNAs such as circRNAs and this synergistic process was precisely regulated by multiple factors ( 53 ).…”

Section: The Role and Molecular Mechanisms Of Circrnas Regulating Par...mentioning

confidence: 99%

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

Wang

Gao

et al. 2022

Front. Oncol.

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CircRNAs have been the focus of research in recent years. They are differentially expressed in various human tumors and can regulate oncogenes and tumor suppressor genes expression through various mechanisms. The diversity, stability, evolutionary conservatism and cell- or tissue-specific expression patterns of circRNAs also endow them with important regulatory roles in promoting or inhibiting tumor cells malignant biological behaviors progression. More interestingly, emerging studies also found that circRNAs can regulate not only other genes expression, but also their parental gene expression and thus influence tumors development. Apart from some conventional features, circRNAs have a certain specificity in the regulation of parental gene expression, with a higher proportion affecting parental gene transcription and easier translation into protein to regulate parental gene expression. CircRNAs are generally thought to be unable to produce proteins and therefore the protein-coding ability exhibited by circRNAs in regulating parental gene expression is unique and indicates that the regulatory effects of parental gene expression by circRNAs are not only a competitive binding relationship, but also a more complex molecular relationship between circRNAs and parental gene, which deserves further study. This review summarizes the molecular mechanisms of circRNAs regulating parental gene expression and their biological roles in tumorigenesis and development, aiming to provide new ideas for the clinical application of circRNAs in tumor-targeted therapy.

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Section: The Role and Molecular Mechanisms Of Circrnas Regulating Par...mentioning

confidence: 99%

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

Wang

Gao

et al. 2022

Front. Oncol.

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“…CircRNAs are closed-loop molecules with unique structures that are widely distributed in animal and plant cells and regulate gene expression. They exist independently of proteins without being affected by exonucleases ( Yue Zhang et al, 2022 ). Because of their low abundance and the limitation of detection technology, circRNAs were initially ignored as abnormal products of RNA splicing ( Wen et al, 2022 ).…”

Section: Noncoding Rnas In Cancermentioning

confidence: 99%

“…Circ-LARP1B/miR-515-5p/TPX2 microtubule nucleation factor regulatory axis is involved in the malignant progression of CSCC by promoting cell viability, colony formation, migration, invasion, cell cycle progression, and glycolysis and inhibiting apoptosis ( Yan Wang et al, 2022 ). Circ_0001821 plays a pro-oncogenic role in CSCC development by regulating the miR-148a-3p/EGFR signaling axis and PI3K/Akt pathway ( Yue Zhang et al, 2022 ).…”

Section: Noncoding Rnas In Skin Cancermentioning

confidence: 99%

Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms

Liu

2022

Front. Pharmacol.

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Cutaneous malignancies, including basal cell carcinoma, cutaneous squamous cell carcinoma, and cutaneous melanoma, are common human tumors. The incidence of cutaneous malignancies is increasing worldwide, and the leading cause of death is malignant invasion and metastasis. The molecular biology of oncogenes has drawn researchers’ attention because of the potential for targeted therapies. Noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, have been studied extensively in recent years. This review summarizes the aspects of noncoding RNAs related to the metastasis mechanism of skin malignancies. Continuous research may facilitate the identification of new therapeutic targets and help elucidate the mechanism of tumor metastasis, thus providing new opportunities to improve the survival rate of patients with skin malignancies.

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“…Circular RNAs (circRNAs) are mainly produced by the reverse splicing of exons of precursor mRNAs. The functions of circRNAs are mainly ceRNA or miRNA sponging, binding with proteins, regulation of precursor mRNAs (pre-mRNA) splicing, regulation of parental gene expression, and potential translation templates for proteins or peptides ( Yan and Bu, 2021 ; Zhang Y. et al, 2022 ). MiRNAs, lncRNAs, and circRNAs may have other ways to regulate the expression of mRNAs or proteins jointly or competitively.…”

Section: Introductionmentioning

confidence: 99%

Role of ferroptosis and ferroptosis-related non-coding RNAs in the occurrence and development of gastric cancer

Lü

Chen

et al. 2022

Front. Pharmacol.

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Gastric cancer (GC) is a malignant cancer of the digestive tract and is a life-threatening disease worldwide. Ferroptosis is a newly discovered form of regulated cell death, which involves the accumulation of iron-dependent lipid peroxides. It has been found that ferroptosis plays an important regulatory role in the occurrence, development, drug resistance, and prognosis of GC. Non-coding RNAs (ncRNAs) play a critical role in the occurrence and progression of a variety of diseases including GC. In recent years, the role of ferroptosis and ferroptosis-related ncRNAs (miRNA, lncRNA, and circRNA) in the occurrence, development, drug resistance, and prognosis of GC has attracted more and more attention. Herein, we briefly summarize the roles and functions of ferroptosis and ferroptosis-related ncRNAs in GC tumorigenesis, development, and prognosis. We also prospected the future research direction and challenges of ferroptosis and ferroptosis-related ncRNAs in GC.

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Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

Cited by 11 publications

References 222 publications

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms

Role of ferroptosis and ferroptosis-related non-coding RNAs in the occurrence and development of gastric cancer

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