Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer

Zhang, Shunhao; Sun, Jing; Gu, Minqi; Wang, Guihua; Wang, Xudong

doi:10.1002/cam4.4398

Cited by 29 publications

(24 citation statements)

References 125 publications

(137 reference statements)

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“…CircRNAs were mainly formed during the processing of RNA polymerase II performing transcriptional functions according to the central dogma ( 50 ). Due to the uncertainty of the gene transcription process, the biosynthesis of circRNAs also had various mechanisms including intron pairing mediated circularization, RNA binding protein mediated circularization, alternative splicing mediated circularization (lariat-driven) and canonical linear splicing mediated circularization (intronic lariat-driven) ( 51 ). According to the splicing method and the corresponding product structure characteristics at the same time, circRNAs could be divided into three types including: exonic circRNAs (ecRNAs), exon-intron circRNAs (EIciRNAs) and intron circRNAs (ciRNAs).…”

Section: The Biogenesis and Classification Of Circrnasmentioning

confidence: 99%

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

Wang

Gao

et al. 2022

Front. Oncol.

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CircRNAs have been the focus of research in recent years. They are differentially expressed in various human tumors and can regulate oncogenes and tumor suppressor genes expression through various mechanisms. The diversity, stability, evolutionary conservatism and cell- or tissue-specific expression patterns of circRNAs also endow them with important regulatory roles in promoting or inhibiting tumor cells malignant biological behaviors progression. More interestingly, emerging studies also found that circRNAs can regulate not only other genes expression, but also their parental gene expression and thus influence tumors development. Apart from some conventional features, circRNAs have a certain specificity in the regulation of parental gene expression, with a higher proportion affecting parental gene transcription and easier translation into protein to regulate parental gene expression. CircRNAs are generally thought to be unable to produce proteins and therefore the protein-coding ability exhibited by circRNAs in regulating parental gene expression is unique and indicates that the regulatory effects of parental gene expression by circRNAs are not only a competitive binding relationship, but also a more complex molecular relationship between circRNAs and parental gene, which deserves further study. This review summarizes the molecular mechanisms of circRNAs regulating parental gene expression and their biological roles in tumorigenesis and development, aiming to provide new ideas for the clinical application of circRNAs in tumor-targeted therapy.

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Section: The Biogenesis and Classification Of Circrnasmentioning

confidence: 99%

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

Wang

Gao

et al. 2022

Front. Oncol.

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“…Overexpression of H19 promotes malignant behavior and induces apoptosis. H19 promotes the expression of the EMT-related marker miR-675 and inhibits p53 expression (Shunhao Zhang et al, 2021). Hcp5 can upregulate EZH2 expression by competitively binding to miR-138-5p, promoting autophagy and suppressing apoptosis by regulating the STAT3/ VEGFR2 pathway, leading to malignant progression of CSCC (Zou et al, 2021).…”

Section: Figurementioning

confidence: 99%

Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms

Liu

2022

Front. Pharmacol.

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Cutaneous malignancies, including basal cell carcinoma, cutaneous squamous cell carcinoma, and cutaneous melanoma, are common human tumors. The incidence of cutaneous malignancies is increasing worldwide, and the leading cause of death is malignant invasion and metastasis. The molecular biology of oncogenes has drawn researchers’ attention because of the potential for targeted therapies. Noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, have been studied extensively in recent years. This review summarizes the aspects of noncoding RNAs related to the metastasis mechanism of skin malignancies. Continuous research may facilitate the identification of new therapeutic targets and help elucidate the mechanism of tumor metastasis, thus providing new opportunities to improve the survival rate of patients with skin malignancies.

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“…Throughout the last decade of research, we have identified a series of circRNAs [ 142 ] as biomarkers of oncogenic/tumor-suppressive genes that exert anti-colorectal-cancer functions. Although the regulation of these functional molecules of circRNAs has gradually entered public view, the research on circRNAs has just begun.…”

Section: Curcumin and Colorectal Cancer Therapy Based On Non-coding R...mentioning

confidence: 99%

Curcumin Targeting Non-Coding RNAs in Colorectal Cancer: Therapeutic and Biomarker Implications

et al. 2022

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Colorectal cancer is one of the most common gastrointestinal malignancies, with high incidence rates, a low rate of early diagnosis, and complex pathogenesis. In recent years, there has been progress made in its diagnosis and treatment methods, but tumor malignant proliferation and metastasis after treatment still seriously affect the survival and prognosis of patients. Therefore, it is an extremely urgent task of current medicine to find new anti-tumor drugs with high efficiency and safety and low toxicity. Curcumin has shown potent anti-tumor and anti-inflammatory effects and is considered a hot spot in the research and development of anti-tumor drugs due to its advantages of precise efficacy, lower toxic side effects, and less drug resistance. Recent studies have revealed that curcumin has anti-tumor effects exerted on the epigenetic regulation of tumor-promoting/tumor-suppressing gene expression through the alteration of expression levels of non-coding RNAs (e.g., lncRNAs, miRNAs, and circRNAs). Herein, we summarize the interaction between curcumin and non-coding RNAs on the occurrence and development of colorectal cancer. The information complied in this review will serve as a scientific and reliable basis and viewpoint for the clinical application of non-coding RNAs in colorectal cancer.

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Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer

Cited by 29 publications

References 125 publications

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

Circular RNAs regulate parental gene expression: A new direction for molecular oncology research

Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms

Curcumin Targeting Non-Coding RNAs in Colorectal Cancer: Therapeutic and Biomarker Implications

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