Circular RNA: A novel potential biomarker for skin diseases

Wu, Xiaoting; Xiao, Yanwei; Ma, Jia; Wang, Aoxue

doi:10.1016/j.phrs.2020.104841

Cited by 44 publications

(33 citation statements)

References 135 publications

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“…74 circRNAs are involved in development and progression of several human diseases including DM, cancers, neurological disorders, cardiovascular diseases, and chronic inflammatory diseases. 85,[93][94][95][96] A growing body of evidence implicates circRNA in the pathogenesis of skin diseases, [97][98][99][100][101][102][103] including impaired wound healing. 73,97,[104][105][106] Earlier studies modelled circRNA roles in chronic wound healing by employing a bioinformatics-based approach to highlight studies that confirmed the role and function of circRNA in chronic wounds in vivo.…”

Section: Circular Rnas In Wound Healingmentioning

confidence: 99%

Epigenetic regulation of cellular functions in wound healing

Pastar

Marjanovic

Stone

et al. 2021

Experimental Dermatology

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Cutaneous wound healing is a complex process involving numerous cell types to accomplish sequential, yet overlapping phases of inflammation, proliferation and tissue remodelling. 1,2 Immediately after injury, blood components are released into the wound, forming a clot which provides a matrix for the influx of inflammatory cells.The inflammatory phase is characterized by leukocyte migration to the wound. Neutrophils primarily remove bacteria, followed by monocytes which further differentiate into macrophages that exert early pro-inflammatory and late anti-inflammatory functions during the healing process. Deposition of the newly synthesized fibrin matrix and granulation tissue formation follow; these are subsequently replaced by collagen and scar tissue during the final stages of wound healing. The proliferative phase of wound healing is characterized by re-epithelialization, neovascularization and extracellular matrix deposition. 1,3 Historically, exploration of the molecular basis of wound healing has included a primary focus on its spatiotemporal regulation. Given the complexity of the wound healing process and its requirement for stringent regulation, epigenetic regulation including histone modifications and DNA methylation is highly likely to play a role. 4,5 Indeed, recent discoveries in the field of non-coding RNAs have identified roles for microRNAs (miRs), circular RNAs (circRNA) and long noncoding RNAs (lncRNA) as global gene expression regulators involved in an array of processes important for successful wound healing. [6][7][8][9] While the primary focus of previous reviews has been on the role of epigenetic modifications in acute wound healing, 4-8 herein we

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Section: Circular Rnas In Wound Healingmentioning

confidence: 99%

Epigenetic regulation of cellular functions in wound healing

Pastar

Marjanovic

Stone

et al. 2021

Experimental Dermatology

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“…Therefore, to advance in this field, novel targets and therapeutic approaches for more effective and long-lasting treatments for CM patients must be explored. Although non coding RNAs (ncRNAs) were for years considered as an irrelevant part of the genome, they have recently emerged as important modulators of several cancers [13][14][15], including CM [16][17][18][19][20][21][22][23][24][25], and found to act as mediators of drug-resistance mechanisms [26].…”

Section: Accepted Articlementioning

confidence: 99%

The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma

et al. 2021

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“…Up to now, accumulating evidence has demonstrated that circular RNAs (circRNAs) play important roles in the occurrence, development and prognosis of various diseases, such as cardiovascular diseases (Aufiero et al, 2019;Zhang and Huang, 2020), immune diseases , tumors (Meng S. et al, 2017), skin diseases (Wu et al, 2020), and so on. However, the regulatory role of m6A in circRNAs remains unclear.…”

Section: Introductionmentioning

confidence: 99%

N6-Methyladenosine Modification Opens a New Chapter in Circular RNA Biology

Guo²,

Wen³

et al. 2021

Front. Cell Dev. Biol.

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As the most abundant internal modification in eukaryotic cells, N6-methyladenosine (m6A) in mRNA has shown widespread regulatory roles in a variety of physiological processes and disease progressions. Circular RNAs (circRNAs) are a class of covalently closed circular RNA molecules and play an essential role in the pathogenesis of various diseases. Recently, accumulating evidence has shown that m6A modification is widely existed in circRNAs and found its key biological functions in regulating circRNA metabolism, including biogenesis, translation, degradation and cellular localization. Through regulating circRNAs, studies have shown the important roles of m6A modification in circRNAs during immunity and multiple diseases, which represents a new layer of control in physiological processes and disease progressions. In this review, we focused on the roles played by m6A in circRNA metabolism, summarized the regulatory mechanisms of m6A-modified circRNAs in immunity and diseases, and discussed the current challenges to study m6A modification in circRNAs and the possible future directions, providing a comprehensive insight into understanding m6A modification of circRNAs in RNA epigenetics.

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Circular RNA: A novel potential biomarker for skin diseases

Cited by 44 publications

References 135 publications

Epigenetic regulation of cellular functions in wound healing

Epigenetic regulation of cellular functions in wound healing

The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma

N6-Methyladenosine Modification Opens a New Chapter in Circular RNA Biology

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