Circular RNA: a new star in neurological diseases

Li, Taoran; Jia, Yan-Jie; Wang, Qun; Shao, Xiaoqiu; Lv, Ruijuan

doi:10.1080/00207454.2016.1236382

Cited by 54 publications

(40 citation statements)

References 68 publications

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“…Accordingly, it has been demonstrated that many circRNAs serve as competing endogenous RNAs to bind with microRNAs (miRNAs) and inhibit the activity and function of the targeted miRNAs [8,9]. With the increasing number of studies on circRNAs, circRNAs have been shown to be involved in the development of several types of diseases, including cancer [10], cardiovascular disease [11], and neurological disorders [12]. Unlike linear RNA, circRNAs have a special circular covalently bonded structure, which facilitates their higher stability and resistance to RNA exonucleases [13].…”

Section: Introductionmentioning

confidence: 99%

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

Zhao

Wang

Ouyang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Recent studies have demonstrated that circular RNAs (circRNAs) can serve as potential molecular markers for disease diagnosis. However, little is known about their diagnostic potential for oral squamous cell carcinoma (OSCC). This study aimed to determine the expression of circRNAs in the saliva of OSCC patients to identify novel biomarkers for OSCC screening. Methods: Microarray screening of circRNA was performed to identify differentially expressed circRNAs in saliva from 3 OSCC patients compared with 3 healthy controls. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the results, and the association between these confirmed salivary circRNAs and clinicopathological features was analyzed using the chi-squared test. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of the circRNAs identified. Preoperative expression and postoperative expression (1 month after the surgery) of hsa_circ_0001874 and hsa_circ_0001971 was also determined. Results: Our results indicated 12 upregulated and 20 downregulated circRNAs in the saliva from the OSCC patients compared with that from the healthy controls. Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). The combination of hsa_circ_0001874 and hsa_circ_0001971 showed an area under the ROC curve of 0.922 (95% confidence interval, 0.883-0.961; P< 0.001). The risk score based on the combination of hsa_circ_0001874 and hsa_circ_0001971 also discriminated patients with OSCC from patients with oral leukoplakia (P< 0.001). Moreover, the expression levels of salivary hsa_circ_0001874 and hsa_circ_0001971 were clearly decreased in the postoperative samples compared with preoperative samples (P< 0.001). Conclusions: This is the first study to demonstrate the potential of salivary hsa_circ_0001874 and hsa_circ_0001971 as biomarkers for the diagnosis of OSCC.

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Section: Introductionmentioning

confidence: 99%

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

Zhao

Wang

Ouyang

et al. 2018

Cell Physiol Biochem

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“…It is known that other kinds of ncRNAs, such as miRNAs play an essential role in the process of CNS development and diseases ( Hill and Lukiw, 2016 ; Persengiev et al, 2011 ; Yin et al, 2015 ). CircRNAs can serve as competing endogenous sponges to miRNAs and therefore by regulating their activities, circRNAs can have notable influence upon the development and diseases of the CNS ( Taulli et al, 2013 ; Lu and Xu, 2016 ; Li et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs: A Novel Player in Development and Disease of the Central Nervous System

Xie

Mao²,

Xiong

et al. 2017

Front. Cell. Neurosci.

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Circular RNAs (circRNAs) own unique capabilities to communicate with nucleic acids and ribonucleoproteins and are emerging as indispensable compositions of the regulatory messages encoded in the genome. Due to lack of 3′ termini, circRNAs are more resistant to degradation by exonuclease RNase R and possess greater stability than linear RNAs. Moreover, circRNAs can act as microRNA (miRNA) sponge and affect messenger RNA (mRNA) splicing and transcription. By virtue of their great stability and elaborate regulatory mechanisms of gene expression, circRNAs play important roles in certain physiological activities. The development, homeostasis and stress response of the central nervous system (CNS) depend upon precise temporal and spatial regulation of gene networks. Moreover, emerging evidence has revealed that circRNAs are spatiotemporally regulated and dynamically expressed during brain development; therefore, they can exert significant influences on CNS development and diseases. In this review, we highlight the biogenesis of circRNAs and their central roles in regulation of CNS development and diseases.

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“…In recent years, with the progression of circRNA research, many researches have reported the participation of circRNAs in the progression of various diseases, including arteriosclerosis (Burd et al, 2010), nervous system disorders (Li et al, 2017b;Akhter, 2018), aging (Westholm et al, 2014), heart failure (Wang et al, 2016), and cancers (Qu et al, 2017;Zhang et al, 2018). Yet, its effect and mechanism in osteogenic differentiation requires more exploration.…”

Section: Discussionmentioning

confidence: 99%

The Circular RNA circRNA124534 Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells Through Modulation of the miR-496/β-Catenin Pathway

Pan

Shen

et al. 2020

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) have been found to be a crucial role in stem cell-associated bone regeneration. However, the functions and underlying mechanisms of circRNAs in the osteogenic differentiation of human dental pulp stem cells (hDPSCs) remain largely unclear. We found that overexpression of circRNA124534 unexpectedly promoted DPSCs osteogenesis in vitro and in vivo. Our results confirmed circRNA124534, acting as a miRNA sponge, directly interacts with miR-496 and consequently regulates β-catenin, which in turn exerts osteogenesis of DPSCs. Enforced expression of miR-496 reversed the osteogenesis of circRNA124534, and suppression of miR-496 enhanced the osteogenic differentiation of DPSCs by promoting β-catenin. In conclusion, our findings demonstrate functions of circRNA124534 in modulating osteogenic differentiation through the miR-496/β-catenin pathway; thus, providing a novel potential target for therapy.

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Circular RNA: a new star in neurological diseases

Cited by 54 publications

References 68 publications

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

Circular RNAs: A Novel Player in Development and Disease of the Central Nervous System

The Circular RNA circRNA124534 Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells Through Modulation of the miR-496/β-Catenin Pathway

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