Circular RNA 0010117 promotes aggressive glioblastoma behavior by regulating the miRNA-6779-5p/SPEN axis

Yang, Xuanyong; Liu, Yue; Zhou, Xinhui; Chen, Kang; Xu, Jiang; Xu, Shan

doi:10.1016/j.tranon.2022.101515

Cited by 7 publications

(9 citation statements)

References 25 publications

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“…In this network ( Figure 6 ), several nodes and interactions involving the feature genes play essential roles in CESC, such as hsa-miR-6779-5p (target genes: OAS3, HDAC2 and IFI6), hsa-miR-1972 (target genes: PINX2, OAS2, ZC3H12C), and hsa-miR-6807-3p (target genes: PDCD6IP, KIN, and EZH2), and all these target genes were upregulated. MiR-6779-5p was also identified as a prognosis-related miRNA ( Yang et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

LncRNA TP53TG1 plays an anti-oncogenic role in cervical cancer by synthetically regulating transcriptome profile in HeLa cells

Cheng

Huang

Yin³

et al. 2022

Front. Genet.

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Long non-coding RNAs (lncRNAs) have been extensively studied as important regulators of tumor development in various cancers. Tumor protein 53 target gene 1 (TP53TG1) is a newly identified lncRNA in recent years, and several studies have shown that TP53TG1 may play oncogenic or anti-oncogenic roles in different cancers. Nevertheless, the role of TP53TG1 in the development of cervical cancer is unclear. In our study, pan-cancer analysis showed that high expression of TP53TG1 was significantly associated with a better prognosis. We then constructed a TP53TG1 overexpression model in HeLa cell line to explore its functions and molecular targets. We found that TP53TG1 overexpression significantly inhibited cell proliferation and induced apoptosis, demonstrating that TP53TG1 may be a novel anti-oncogenic factor in cervical cancer. Furthermore, overexpression of TP53TG1 could activate type I interferon signaling pathways and inhibit the expression of genes involved in DNA damage responses. Meanwhile, TP53TG1 could affect alternative splicing of genes involved in cell proliferation or apoptosis by regulating the expression of many RNA-binding protein genes. Competing endogenous RNA (ceRNA) network analysis demonstrated that TP53TG1 could act as the sponge of several miRNAs to regulate the expression level of target genes. In conclusion, our study highlights the essential role of lncRNA TP53TG1 in the development of cervical cancer and suggests the potential regulatory mechanisms.

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Section: Resultsmentioning

confidence: 99%

LncRNA TP53TG1 plays an anti-oncogenic role in cervical cancer by synthetically regulating transcriptome profile in HeLa cells

Cheng

Huang

Yin³

et al. 2022

Front. Genet.

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“…SPEN seems to act as an oncogene in nasopharyngeal carcinoma ( Li et al 2020b ), as well as colon and ovarian endometroid adenocarcinomas ( Feng et al 2007 ). Its tumor suppressor functions were linked with glioblastoma ( Yang et al 2022 ), breast cancer ( Légaré et al 2015 ), adenoid cystic carcinoma ( Stephens et al 2013 ), lymphoma ( Rossi et al 2012 ), prostate cancer ( Armenia et al 2018 ), small cell lung cancer ( Jiao et al 2022 ), and esophageal squamous cell carcinoma ( Zhang et al 2020 ).…”

Section: Spoc Proteins In Cancermentioning

confidence: 99%

“…In glioblastoma, the expression of SPEN and its circular RNA ( circ-0010117 ) are reduced ( Yang et al 2022 ). CircRNAs are transcripts generated from introns or exons of the original mRNA ( Goodall and Wickramasinghe 2021 ).…”

Section: Spoc Proteins In Cancermentioning

confidence: 99%

“…They act as sponges for microRNAs, and several studies identified a link with cancer development ( Goodall and Wickramasinghe 2021 ). Silencing of circ-0010117 or SPEN in U251 and U87 glioblastoma cells causes increased proliferation, enhanced migration, and reduced apoptosis, whereas inoculation of U251 cells overexpressing circ-0010117 into 4-wk-old nude mice reduced tumor size ( Yang et al 2022 ). The noncoding RNA miR-6779-5p can reverse the effect of circ-0010117 overexpression and down-regulate SPEN ( Yang et al 2022 ).…”

Section: Spoc Proteins In Cancermentioning

confidence: 99%

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SPOC domain proteins in health and disease

et al. 2023

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Since it was first described >20 yr ago, the SPOC domain (Spen paralog and ortholog C-terminal domain) has been identified in many proteins all across eukaryotic species. SPOC-containing proteins regulate gene expression on various levels ranging from transcription to RNA processing, modification, export, and stability, as well as X-chromosome inactivation. Their manifold roles in controlling transcriptional output implicate them in a plethora of developmental processes, and their misregulation is often associated with cancer. Here, we provide an overview of the biophysical properties of the SPOC domain and its interaction with phosphorylated binding partners, the phylogenetic origin of SPOC domain proteins, the diverse functions of mammalian SPOC proteins and their homologs, the mechanisms by which they regulate differentiation and development, and their roles in cancer.

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“…Yang et al. revealed that Circular RNA 0010117 (circ-0001946) promotes aggressive glioblastoma behavior by regulating the miRNA-6779-5p/SPEN axis [10] . It provided the rationale for the use of circ-0001946 as a novel potential therapeutic target in glioblastoma.…”

mentioning

confidence: 99%