Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer

Zhu, Min; Xu, Yu; Chen, Yun; Yan, Feng

doi:10.1016/j.biopha.2016.12.097

Cited by 156 publications

(110 citation statements)

References 30 publications

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“…Previous studies have reported that circRNAs play a crucial role in cancer biological processes, such as proliferation, migration, and metastasis. [33][34][35][36] Our study revealed that the decreased hsa_circ_0000567 was negatively correlated with tumor size, lymph metastasis, distal metastasis, and TNM stage in patients with CRC (Table 1). Consistent with the findings in CRC tissue samples, hsa_circ_0000567 expression in CRC cell lines was also associated with the metastasis ability of cells ( Figure 3C).…”

Section: Discussionmentioning

confidence: 83%

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Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer

Wang

et al. 2018

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 83%

“…Previous studies have reported that circRNAs play a crucial role in cancer biological processes, such as proliferation, migration, and metastasis . Our study revealed that the decreased hsa_circ_0000567 was negatively correlated with tumor size, lymph metastasis, distal metastasis, and TNM stage in patients with CRC (Table ).…”

Section: Discussionmentioning

confidence: 99%

Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer

Wang

et al. 2018

Clinical Laboratory Analysis

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“…Yin et al (2017) revealed the potential diagnostic value of plasma hsa circ 0001785 for breast cancer. A close relationship was recently found between circR-NAs and various tumors (including cutaneous squamous cell carcinoma, colorectal cancer, gastric cancer, osteosarcoma, and lung cancer) (Chen, Li, Zhao, Xiao, & Guo, 2017;Deng et al, 2017;Sand et al, 2016;Tian, Yu, Ye, & Wang, 2017;Zhu, Xu, Chen, & Yan, 2017). At present, there are few reports on the relationship between mycotoxins and these noncoding RNAs, despite the above-mentioned indication of noncoding RNAs as potential therapeutic targets for mycotoxin-induced diseases.…”

Section: Other Noncoding Rnas As New Biomarkersmentioning

confidence: 88%

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

Xue

Sun‐Waterhouse

Wang

et al. 2018

Comp Rev Food Sci Food Safe

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Mycotoxins are contaminants commonly found in foods and represent a worldwide threat to human health and welfare. Efforts have been undertaken to reduce mycotoxins and their toxicity, including the introduction of good agricultural practices, appropriate food processing, specific biotransformation approaches, and pursue therapeutic agents to counteract mycotoxins. Efficient and predictive tools are required for investigations on mycotoxins and their toxicodynamics, and strategies for mycotoxin reduction. Gene expression and transcriptome analysis can unravel the mode of action, transformation and combined toxicity of mycotoxins, or mycotoxin's interactions with food components including dietary therapeutics, at the cellular level and from a molecular perspective. MicroRNAs (miRNAs) regulate endogenously and posttranscriptionally the expression of target genes and enzymes involved in physiological, disease and toxicological responses, and the metabolism of therapeutic agents. Accordingly, this review aimed to collect up‐to‐date information on (1) the regulatory role of miRNAs in mycotoxin‐initiated toxicological processes and (2) the protective role of active ingredients from plants on mycotoxin‐induced toxicity. Through such a review of published evidence, we found some common signal pathways involving miRNAs shared by these two types of biological events. This finding indicates the possibility of using miRNAs as biomarkers in assessing and controlling mycotoxins in food via cellular mechanisms.

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“…Recently, the role of circRNAs in cancer was also highlighted. circRNAs may become the new target of tumor therapy, such as colorectal cancer, gastric cancer, colon cancer . CDR1as play a vital role in melanoma invasion and metastasis .…”

Section: Discussionmentioning

confidence: 99%

Comprehensive circRNA expression profile and construction of circRNA‐associated ceRNA network in fur skin

Zhu

Liu

et al. 2018

Experimental Dermatology

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Circular RNA (circRNA), a class of non-coding RNAs, is a new group of RNAs that are related to tumorigenesis. The role of circRNAs in various diseases has been already highlighted. However, the expression levels and functions of circRNAs related to the melanocytes in the skin are poorly understood. RNA sequence was performed to analyse the expression profiles of circRNAs in black fur skin and white fur skin during different differentiation stages and investigate the relevant metabolism mechanisms. Differentially expressed circRNAs were detected using empirical Bayes sequencing (EBSeq) and then verified through the quantitative real-time PCR method. The EQSeq analysis of circRNAs identified 11 downregulated and 32 upregulated circRNAs in the embryo of black fur skin and white fur skin, as well as 21 downregulated and 17 upregulated circRNA in the postnatal stage. A circRNA-microRNA (miRNA)-messenger RNA (mRNA) network was established to predict the circRNA targets. Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were applied to enrich the mRNA data further. Results showed that the specific mRNAs mainly involved in the transcription-related GOs, especially GO:0042802, GO:0005080 and GO:0032403, demonstrate their specific actions in transcriptional regulation. In the circRNA-miRNA-mRNA network, the most enriched GO terms of the mRNAs were pigmentation, protein autophosphorylation and protein complex. Therefore, the circRNA-miRNA-mRNA pathway may reveal novel mechanisms for pigmentation, and circRNAs may serve as candidates in pigmentation.

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Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer

Cited by 156 publications

References 30 publications

Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer

Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

Comprehensive circRNA expression profile and construction of circRNA‐associated ceRNA network in fur skin

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