“…Signal amplification Higher amplification 9,10,36,[69][70][71][72] Noise attenuation^ Attenuated noise 57,[72][73][74] Information transmission^ Higher transmission 57,[72][73][74] Robustness to changes in parameter values High robustness (low sensitivity) 9,10,36,58,69 Speed of response to changes Rate of adaptation 9,10,29,36,48,71,75 Metabolic cost of circuit Low cost 76,77 *as a general trend; ^ Relevant in the stochastic domains of dynamic behavior. Table S4 -Numerical values of the rate constants of the 19 reactions in the PR models used in the stochastic simulations, represented in Figure 4.…”