Circuit-based intervention corrects excessive dentate gyrus output in the Fragile X mouse model
Pan-Yue Deng,
Ajeet Kumar,
Valeria Cavalli
et al.
Abstract:Abnormal cellular and circuit excitability is believed to drive many core phenotypes in fragile X syndrome (FXS). The dentate gyrus is a brain area performing critical computations essential for learning and memory. However, little is known about dentate circuit defects and their mechanisms in FXS. Understanding dentate circuit dysfunction in FXS has been complicated by the presence of two types of excitatory neurons, the granule cells and mossy cells. Here we report that loss of FMRP markedly decreased excita… Show more
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