CircSOD2: Disruption of intestinal mucosal barrier function in ulcerative colitis by regulating the miR‐378g/Snail1 axis
Guannan Ye,
Jiayi Zhang,
Jin Peng
et al.
Abstract:Background and AimCircular RNA (circRNA) has been found to mediate ulcerative colitis (UC) progression by regulating intestinal mucosal barrier function. However, the role of circSOD2 in UC process and its underlying molecular mechanism still need to be further elucidated.MethodsLipopolysaccharide (LPS)‐induced Caco2 cells were used to mimic UC cell models. CircSOD2, miR‐378g, and Snail1 levels were determined by quantitative real‐time PCR. Cell viability was detected using MTT assay, and inflammatory cytokine… Show more
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