CircRNAs expression profile of persistant atrial fibrillation in patient with rheumatic heart disease

Hu, Miaoyang; Wei, Xufeng; Li, Meng; Tao, Ling; Wei, Liping; Zhang, Minxia; Cheng, Hongwei; Yuan, Yuan

doi:10.14744/anatoljcardiol.2018.35902

Cited by 24 publications

(27 citation statements)

References 35 publications

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“…MicroRNA is a hot topic in the field of cardiovascular research in recent years [ 7–9 ]. Nevertheless, there are few reports of microRNA in the research of RHD [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease

Zhu

Zhou

et al. 2020

Bioscience Reports

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To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B cell lymphoma-2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PBMCs and THP-1 cell models. The binding of miR-1183 and Bcl-2 gene was confirmed by luciferase activity test.We also measured expression levels of BCL-2 in heart valve tissue from patients with RHD using ELISA and immunohistochemistry. In silico analysis and reporter gene assays indicated that miR-1183 directly targets the mRNA encoding BCL-2. It is found that miR-1183 binds directly to the 3’ UTR of the BCL-2 mRNA and downregulates the mRNA and protein levels of BCL-2.Overexpression of miR-1183 in RHD patients and cell lines downregulated BCL-2 expression and induced apoptosis. With the progression of the disease, the expression of BCL-2 in the heart valve tissue of patients with RHD decreased. MiRNA-1183 is upregulated in RHD and induces cardiac myocyte apoptosis through direct targeting and suppression of BCL-2, both of which might play important roles in RHD pathogenesis. During the compensatory period of RHD, up-regulated miR-1183 destroyed the balance of apoptosis proteins (Bax、BAK) in bcl-2 family, enhance the apoptosis cascade reaction and reduce the anti apoptosis effect.The significantly higher expression levels of miR-1183 appear to play distinct roles in RHD pathogenesis by regulation BCL-2, possibly affecting myocardial apoptosis and remodeling in the context of RHD.

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“…MicroRNA is a hot topic in the field of cardiovascular research in recent years [ 7–9 ]. Nevertheless, there are few reports of microRNA in the research of RHD [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease

Zhu

Zhou

et al. 2020

Bioscience Reports

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“…Hu M et al established circRNA expression profiles of persistent atrial fibrillation(AF) in cases carrying rheumatic heart disease. Circ_19591, circ_ 19596 and circ_16175 showed interactions to 36, 28, and 18 miRNAs, respectively; miR-29b-1-5p and miR-29b-2-5p displayed associations with 12 reduced circRNAs, respectively, which proposes an emerging perspective on circRNAs that participate part in AF for rheumatic heart disease and then lays a foundation for subsequent studies on the probable effects of circRNAs on AF [75].…”

Section: Circrnas In Viral and Bacterial Infectionsmentioning

confidence: 86%

The emerging landscape of circular RNAs in immunity: breakthroughs and challenges

Cheng

et al. 2020

Biomark Res

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Circular RNAs (circRNAs) are covalently linked RNAs that exhibit individual strand with a closed-loop framework compared with a conserving, steady and abundant linear counterpart. In recent years, as high-throughput sequencing advancement has been developing, functional circRNAs have been increasingly recognized, and more extensive analyses expounded their effect on different diseases. However, the study on the function of circRNAs in the immune system remains insufficient. This study discusses the basic principles of circRNAs regulation and the systems involved in physiology-related and pathology-related processes. The effect of circRNAs on immune regulation is elucidated. The ongoing development of circRNAs and basic immunology has multiplied their potential in treating diseases. Such perspective will summarize the status and effect of circRNAs on various immune cells in cancer, autoimmune diseases and infections. Moreover, this study will primarily expound the system of circRNAs in T lymphocytes, macrophages and other immune cells, which creates a novel perspective and lay a theoretical basis for treating diseases.

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“…In addition, by studying the circRNA expression profiles in atrial tissues from patients with persistent atrial fibrillation (AF) with rheumatic heart disease, Hu et al 104 predicted the potential roles of the differentially expressed circRNAs. The results suggested that 51 circRNAs were upregulated, and 57 circRNAs were downregulated in AF tissues compared with controls, respectively.…”

Section: Circrnas In Autoimmune Diseasesmentioning

confidence: 99%

Roles of circular RNAs in immune regulation and autoimmune diseases

et al. 2019

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Circular RNAs (circRNAs), as a novel class of endogenously expressed non-coding RNAs (ncRNAs), have a high stability and often present tissue-specific expression and evolutionary conservation. Emerging evidence has suggested that circRNAs play an essential role in complex human pathologies. Notably, circRNAs, important gene modulators in the immune system, are strongly associated with the occurrence and development of autoimmune diseases. Here, we focus on the roles of circRNAs in immune cells and immune regulation, highlighting their potential as biomarkers and biological functions in autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), primary biliary cholangitis (PBC), and psoriasis, aiming at providing new insights into the diagnosis and therapy of these diseases. Facts • CircRNAs are related to various biological processes in immune cells, as well as immune regulation under multifarious physiological and pathological conditions. • CircRNAs serve as potential biomarkers for the diagnosis and severity of certain autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), primary biliary cholangitis (PBC). • CircRNAs contribute to the development of autoimmune diseases by acting as miRNA sponges to regulate many biological processes, including DNA methylation, immune response, and inflammatory response. • Certain circRNAs, such as cia-cGAS and dsRNA-containing circRNAs, may act as potential targets for the treatment of autoimmune diseases.

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CircRNAs expression profile of persistant atrial fibrillation in patient with rheumatic heart disease

Cited by 24 publications

References 35 publications

miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease

miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease

The emerging landscape of circular RNAs in immunity: breakthroughs and challenges

Roles of circular RNAs in immune regulation and autoimmune diseases

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