CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression

Chen, Daishi; Ma, Wei; Ke, Zhaoyang; Xie, Fei

doi:10.1080/15384101.2018.1515553

Cited by 169 publications

(141 citation statements)

References 34 publications

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“…This means that the circ_0001649/miR‐331‐3p and circ_0001649/miR‐338‐5p regulatory axis may contribute to tumorigenesis and progression of NSCLC. Hsa_circ_100395 is downregulated in lung cancer tissues and cells and acts as a sponge of miR‐1228 to regulate transcription factor 21 (TCF21) expression, thus inhibiting the proliferation activity, migration, and invasion of lung cancer cells . Another study found that circ_0006916 bound miR‐522‐3p and then directly targeted the PH domain and leucine‐rich repeat protein phosphatases (PHLPP1) .…”

Section: Tumor‐suppressive Circrnas and Cancersmentioning

confidence: 99%

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

et al. 2019

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internal ribosome entry site; LARP4, La-related protein 4; LATS1, large tumor suppressor kinase 1; lncRNAs, long noncoding RNAs; MIBC, muscle invasive bladder cancer; miRNA, microRNA; ncRNAs, noncoding RNAs; NF1, neurofibromin 1; Notch1, notch homolog 1; NSCLC, non-small cell lung cancer; OS, overall survival; PCK1, phosphoenolpyruvate carboxykinase 1; PDAC, pancreatic ductal adenocarcinoma; RBP, RNA-binding protein; RCAN1, regulation of Down syndrome critical region gene 1; sncRNAs, short noncoding RNAs; TIMP3, metalloproteinase inhibitor 3; USP28, ubiquitin-specific peptidase 28; YBX1, Y box binding protein 1. AbstractCircular RNAs (circRNAs) have a covalently closed circular conformation and are structurally stable. Those circRNAs with tumor-suppressive properties play an important role in tumorigenesis and metastasis and thus may be used as therapeutic targets of cancers. Herein, we review the current understanding of the classification of circRNAs and summarize the functions and mechanisms of circRNAs that have tumor-suppressive roles in various cancers, including liver cancer (circARSP91, circ-ADAMTS13, circADAMTS14, circMTO1, hsa_circ_0079299, and circC3P1), bladder cancer (circFNDC3B, circITCH, circHIPK3, circRNA-3, cdrlas, and circLPAR1), gastric cancer (circLARP4, circYAP1, hsa_cric_0000096, hsa_circ_0000993, and circPSMC3), breast cancer (circ_000911, hsa_circ_0072309, and circASS1), lung cancer (hsa_ circ_0000977, circPTK2, circ_0001649, hsa_circ_100395, and circ_0006916), glioma (circ_0001946, circSHPRH, and circFBXW7), and colorectal cancer (circITGA7 and hsa_circ_0014717). Thanks to their structural stability, these tumor-suppressive cir-cRNAs may be used as potential and potent therapeutic targets. Moreover, we propose a new method for the classification of circRNAs. Based on whether they can be translated, circRNAs can be divided into noncoding circRNAs and coding circRNAs. K E Y W O R D Sbiogenesis, cancer, circular RNA, mechanism, therapeutic target | INTRODUC TI ONThose RNAs that do not encode proteins are called ncRNAs. 1 Regulatory ncRNAs are divided into lncRNAs and sncRNAs. LncRNAs can be linear or circular. 2 Circular RNAs were first discovered in 1976. 3 Since then, a variety of circRNAs have been discovered. 4,5 CircRNAs are more resistant to exonuclease and are more stable than other lncRNAs. 3,6 They exist in exosomes and plasma. 6,7 Li et al identified more than 1000 circRNAs in human serum exosomes. 6 Li et al found 343 differentially How to cite this article:

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Section: Tumor‐suppressive Circrnas and Cancersmentioning

confidence: 99%

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

et al. 2019

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“…4 circRNAs, a group of important endogenous non-coding RNAs, mainly consist of transcripts from exons and exert important roles in the downstream gene regulation. 11,12 miRNAs are another group ofnon-coding RNAs containing approximately 22 nucleotides, with a role of regulating gene expression. Thus, compared to their linear counterparts, circRNAs are extraordinarily stable in vivo due to their resistance to exonuclease.…”

Section: Introductionmentioning

confidence: 99%

“…For example, circRNA has_circ_100395 inhibits lung cancer progression through the miR-1228/TCF21 axis, while ciRS-7 promotes oesophageal squamous cell carcinoma tumour growth and metastasis by inducing miR-7/HOXB13 axis. 11,12 miRNAs are another group ofnon-coding RNAs containing approximately 22 nucleotides, with a role of regulating gene expression. 13 A recent evidence suggests that miRNAs are involved in tumorigenesis and tumour development, functioning as gene silencers at a post-transcriptional level.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA cMras inhibits lung adenocarcinoma progression via modulating miR‐567/PTPRG regulatory pathway

Tian

et al. 2019

Cell Proliferation

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Objectives: Circular RNA, a type of RNA formed by a covalently closed loop, possesses sophisticated abilities of gene regulation in tumorigenesis and metastasis.However, the role of circRNAs on lung adenocarcinoma (LUAD) remains largely unknown. Materials and methods:The role of cMras was examined both in vitro and in vivo.cMras expression in LUAD tissues was determined by quantitative real-time PCR (qRT-PCR). Downstream targets of cMras were predicted by bioinformatics tools and confirmed by RNA immunoprecipitation assay and luciferase assay. qRT-PCR and western blot assay were used to detect the expression of specific targets.Results: Thirty-six paired LUAD and healthy tissues were collected and cMras resulted significantly downregulated in cancerous tissues. Its expression was negatively associated with tumour stages. cMras overexpression suppressed LUAD growth and metastasis, while endogenous cMras silencing resulted in the opposite effects. Bioinformatics analysis and experimental evidence confirmed that cMras was a sponge of miRNA-567 and released its direct target, PTPRG. cMras overexpression decreased miR-567 expression and subsequently increased PTPRG expression, while increased miRNA-567 expression blocked the effects induced by cMras.Moreover, PTPRG was downregulated in LUAD and patients with low PTPRG expression exhibited significantly poor prognosis. These results suggested that cMras/ miR-567/PTPRG regulatory pathway might be associated to LUAD tumorigenesis and development. Conclusions:A novel circular RNA cMras and its functions were identified, discovering a cMras/miR-567/PTPRG regulatory pathway in LUAD tumorigenesis and development.

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“…Functionally, circRNAs could regulate the protein function via cap‐independent mechanism, affect the splicing of parental genes and serve as the microRNAs (miRNAs) sponges to cross‐talk with miRNAs . Emerging evidence has proven that circRNAs played important roles in the development of normal tissues and various diseases, such as cardiovascular diseases, age‐related diseases, autoimmune diseases and tumours . Their functions as potential biomarkers were gradually discovered in cancers and neurodegenerative disorders .…”

Section: Introductionmentioning

confidence: 99%

“…[21][22][23] Emerging evidence has proven that cir-cRNAs played important roles in the development of normal tissues and various diseases, such as cardiovascular diseases, age-related diseases, autoimmune diseases and tumours. [24][25][26][27][28][29][30] Their functions as potential biomarkers were gradually discovered in cancers and neurodegenerative disorders. 31,32 However, it remains unclear that the comprehensive expression patterns of circRNAs and the roles of them played in the NELL-1-induced osteogenesis of hASCs.…”

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confidence: 99%

The roles of circRFWD2 and circINO80 during NELL‐1‐induced osteogenesis

Huang

Cen

Zhang

et al. 2019

J Cellular Molecular Medi

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Bone defects caused heavy social and economic burdens worldwide. Nel‐like molecule, type 1 (NELL‐1) could enhance the osteogenesis and the repairment of bone defects, while the specific mechanism remains to be elucidated. Circular RNAs (circRNAs) have been found to play critical roles in the tissue development and serve as biomarkers for various diseases. However, it remains unclear that the expression patterns of circRNAs and the roles of them played in recombinant NELL‐1‐induced osteogenesis of human adipose‐derived stem cells (hASCs). In this study, we performed RNA‐sequencing to investigate the expression profiles of circRNAs in recombinant NELL‐1‐induced osteogenic differentiation and identified two key circRNAs, namely circRFWD2 and circINO80. These two circRNAs were confirmed to be up‐regulated during recombinant NELL‐1‐induced osteogenesis, and knockdown of them affected the positive effect of NELL‐1 on osteogenesis. CircRFWD2 and circINO80 could interact with hsa‐miR‐6817‐5p, which could inhibit the osteogenesis. Silencing hsa‐miR‐6817‐5p could partially reverse the negative effect of si‐circRFWD2 and si‐circINO80 on the osteogenesis. Therefore, circRFWD2 and circINO80 could regulate the expression of hsa‐miR‐6817‐5p and influence the recombinant NELL‐1‐induced osteogenic differentiation of hASCs. It opens a new window to better understanding the effects of NELL‐1 on the osteogenic differentiation of hASCs and provides potential molecular targets and novel methods for bone regeneration efficiently and safely.

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CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression

Abstract: circRNA: circular RNA; miRNA: microRNA; RNA-FISH: RNA fluorescence in situy bridization; qRT-PCR: Reverse transcription and quantitative real-time PCR.

Cited by 169 publications

References 34 publications

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

Circular RNA cMras inhibits lung adenocarcinoma progression via modulating miR‐567/PTPRG regulatory pathway

The roles of circRFWD2 and circINO80 during NELL‐1‐induced osteogenesis

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