CircRNA Hsa_circ_0001017 Inhibited Gastric Cancer Progression via Acting as a Sponge of miR-197

Shan, Changping; Wang, Junye; Hu, Chengjiu

doi:10.1007/s10620-020-06516-8

Cited by 18 publications

(9 citation statements)

References 22 publications

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“…NSC12618, a highly active anticancer compound, enhanced RhoB expression via c-Jun N-terminal kinase signaling and caused death in gastric carcinoma NUGC-3 cells [ 30 ]. Li et al suggested that by targeting the miR-197/RhoB signaling pathway, the circRNA Hsa_circ_0001017 suppressed GC cell proliferation, movement, and infiltration [ 31 ]. KR28 (1-allyl-4-dodecanoyl-1-ethyl-piperazin-1-ium; bromide), a new anticancer drug, promoted apoptosis by upregulating c-Abl and activating p38 MAPK/ATF-2 in response to ROS-mediated RhoB production [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

MiR-223 Promotes Tumor Progression via Targeting RhoB in Gastric Cancer

Chen

et al. 2022

Journal of Oncology

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Gastric cancer (GC) is among the most prevalent causes of cancer-related death globally. MiR-223 has been implicated in a variety of cellular mechanisms linked to cancer progression. However, the miR-223 expressions and its function in GC are unknown. We discovered that miR-223 expression was raised in GC tissues in comparison with nearby normal tissues in this investigation. Additionally, multiplied miR-223 expression was strongly linked with TNM stage ( p = 0.022 ), live metastasis ( p = 0.004 ),lymph node metastasis ( p = 0.004 ),and Borrmann type and was associated with an unfavorable prognostic for patients with GC. Furthermore, suppressing miR-223 significantly increased cell death and prevented cell migration and invasion in vitro. Additionally, miR-223 silencing decreased tumor development in vivo. Additionally, we discovered that miR-223 enhanced GC development by specifically targeting RhoB. In summary, our findings reveal that miR-223 increases tumor progression in GC by targeting RhoB, suggesting that it could serve to be a potential biomarker for the prediction of the disease.

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Section: Discussionmentioning

confidence: 99%

MiR-223 Promotes Tumor Progression via Targeting RhoB in Gastric Cancer

Chen

et al. 2022

Journal of Oncology

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“…As our best knowledge, hsa_circ_0005035 was notably lower in lung cancer tissues and lung cancer cell lines than in the adjacent normal tissues and cells [ 17 ]. Hsa_circ_0001017 expression was decreased in glioma [ 18 ] and gastric cancer [ 19 ] tissues and cells. The opposite expression levels of hsa_circ_0001017 and hsa_circ_0005035 might be ascribed to different tumor backgrounds.…”

Section: Discussionmentioning

confidence: 99%

“…These data suggested that circ_0001017 might be an oncogene in the development of OS. Although the oncogenic role of circ_0001017 has not been reported yet, circ_0001017 as a tumor suppressor has been demonstrated as follows: Upregulation of hsa_circ_0001017 could notably muffle the proliferation as well as the metastasis of gastric cancer (GC) cell lines and impede the formation of GC tumor [ 19 ]. Overexpression of hsa_circ_0001017 inhibited glioma cell proliferation, migration and invasion and promoted glioma cell apoptosis, while the knockdown of hsa_circ_0001017 caused the opposite results [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p

Yang

2022

J Orthop Surg Res

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Background Circular RNAs (circRNAs) have displayed important roles in the development and progression of various cancers. However, the functions of the majority of circRNAs in osteosarcoma (OS) remain unknown. Methods Circular RNA microarray analysis was performed in three OS cell lines (Saos-2, U2OS and MG63) and normal vascular endothelial cells. The co-differentially expressed circRNAs (CDECs) were identified in OS cell lines with the criterion of FDR (false discovery rate) < 0.05 and |fold change (FC)|> 2. Quantitative real-time PCR was used to validate the expression levels of selected CDECs. A series of functional assays, including MTT assay, flow cytometry and transwell assay were conducted in OS cells. The interaction between circRNA and miRNAs was confirmed by luciferase reporter assay and RNA immunoprecipitation assay. Results A total of 241 CDECs, including 75 upregulated and 166 downregulated CDECs, were identified in three OS cell lines compared with normal vascular endothelial cells. PCR validation showed that hsa_circ_0000704, hsa_circ_0001017 and hsa_circ_0005035 were all highly expression in the three OS cell lines, compared with osteoblast cell lines (HECC, hFOB1.19 and HFF-1). Functionally, overexpression of circ_0001017 significantly promoted the cell proliferation, migration and invasion and decreased apoptosis in U2OS cells. Knockdown of circ_0001017 obtained the opposite results. Circ_0001017 may downregulate miR-145-5p through direct binding. Furthermore, the expression of miR-145-5p was negatively regulated by circ_0001017 in OS cells. In addition, further functional studies indicated that miR-145-5p inhibitor eliminated the effects caused by si-circ_0001017 in OS cells. Conclusions In conclusion, our study suggested that circ_0001017 may be a novel oncogenic factor during the progression and development of OS by targeting miR-145-5p.

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“…Owing to their highly stable structural makeup, circRNAs can be readily detected in patient serum samples and in harvested exosomes, making them promising diagnostic targets. Indeed, prior studies have highlighted the value of circRNA-based diagnostic analyses in breast [ 7 , 8 ], colorectal [ 9 , 10 ], liver [ 11 , 12 ], gastric [ 13 , 14 ], and non-small cell lung cancer [ 15 , 16 ]. Functionally, these circRNAs can regulate diverse oncogenic activities such as the migration, proliferation, and survival of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Identification of circRNA_001846 as putative non–small cell lung cancer biomarker

Yang

Qiu

et al. 2021

Bioengineered

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CircRNAs play diverse roles in the regulation of oncogenic processes, yet the roles of these circRNAs in non-small cell lung cancer (NSCLC) remain to be fully clarified. Herein, patterns of circRNA expression in NSCLC tissues and paracancerous tissues were assessed, and the relationships between these circRNAs and NSCLC patient clinical findings were assessed. NSCLC tissues were evaluated using a circRNA microarray approach, with Quantitative real time polymerase chain reaction (qPCR) qPCR being used to validate candidate circRNA expression levels in NSCLC patients peripheral blood samples. GEO2R was used to analyze the array data. SPSS23.0, GraphPad Prism, and Sigmaplot were utilized for statistical analyses. Overall, 114 circRNAs that were differentially expressed in NSCLC tissue relative to paracancerous tissue levels were identified, of which 77 and 37 were downregulated and upregulated, respectively. CircRNA_001846 were then chosen based on its differential expression score. Consistent with array findings, serum samples from NSCLC patients exhibited circRNA_001846 upregulation relative to those from healthy individuals. The circRNA_001846 was associated with tumor differentiation, lymph node metastasis, and node metastasis stage. Receiver operating characteristic (ROC) curves analyses revealed that levels of circRNA_001846 in the serum were capable of differentiating between individuals diagnosed with NSCLC and controls at a cut off of 3.9496, yielding respective sensitivity and specificity values of 78.2% and 81.1%, with an area under the curve (AUC) value of 0.872. When combined with carcinoembryonic antigen (CEA), this circRNA achieved an improved AUC value of 0.925. CircRNA_001846 may represent a promising diagnostic biomarker for NSCLC.

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CircRNA Hsa_circ_0001017 Inhibited Gastric Cancer Progression via Acting as a Sponge of miR-197

Cited by 18 publications

References 22 publications

MiR-223 Promotes Tumor Progression via Targeting RhoB in Gastric Cancer

MiR-223 Promotes Tumor Progression via Targeting RhoB in Gastric Cancer

Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p

Identification of circRNA_001846 as putative non–small cell lung cancer biomarker

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