CircRNA circHIPK3: A novel, potential therapeutic target in the treatment of angiotensin II-induced cardiac fibrosis?

Li, Jingwen; Cui, Jinzhen; Lin, Yanyu

doi:10.1016/j.ijcard.2020.08.083

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The Role Of Circhipk3 In Cardiovascular Disease1

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2022

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“…Overexpressed circHIPK3 strengthened TGF-β2 signaling pathway by hampering miR-152-3p so as to accelerate the process of fibrosis [ 90 ]. Liu et al along with Ni and colleagues also demonstrated that silencing circHIPK3 contributed to retard cardio fibrosis triggered by angiotensin II [ 91 , 92 ]. Ni and colleagues further discovered the miRNA sponged by circHIPK3 as miR-29b-3p in their study [ 92 ].…”

Section: The Role Of Circhipk3 In Cardiovascular Diseasementioning

confidence: 99%

The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases

Yan-fei

Yang

et al. 2022

Diagnostics

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Circular RNAs (circRNAs) are a class of noncoding RNAs with closed-loop of single-stranded RNA structure. Although most of the circRNAs do not directly encode proteins, emerging evidence suggests that circRNAs play a pivotal and complex role in multiple biological processes by regulating gene expression. As one of the most popular circRNAs, circular homeodomain-interacting protein kinase 3 (circHIPK3) has frequently gained the interest of researchers in recent years. Accumulating studies have demonstrated the significant impacts on the occurrence and development of multiple human diseases including cancers, cardiovascular diseases, diabetes mellitus, inflammatory diseases, and others. The present review aims to provide a detailed description of the functions of circHIPK3 and comprehensively overview the diagnostic and therapeutic value of circHIPK3 in these certain diseases.

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