CircRBM33 regulates IL-6 to promote gastric cancer progression through targeting miR-149

Wang, Ning; Lu, Keyu; Qu, Huiheng; Wang, Hao; Chen, Yigang; Shan, Ting; Ge, Xuhui; Yun-yu, Wei; Zhou, Peng; Xia, Jiazeng

doi:10.1016/j.biopha.2020.109876

Cited by 38 publications

(19 citation statements)

References 42 publications

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“…New evidence reveals the role of circRNA in diverse biological process [ 11 ], and notably in gastric cancer. For example, circRBM33 promotes gastric cancer progression by upregulating IL-6 trough targeting miR-149 [ 12 ]. circRNAs are usually proposed to act as molecular sponges to regulate miR expression [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Circ_002117 binds to microRNA-370 and promotes endoplasmic reticulum stress-induced apoptosis in gastric cancer

et al. 2020

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Background Mounting evidence implicates circular RNAs (circRNAs) in various biological processes during cancer progression. Gastric cancer is a main cause of cancer-related deaths worldwide. Herein, we aimed at investigating whether circ_002117 mediates gastric cancer progression through endoplasmic reticulum (ER) stress. Methods Bioinformatics analysis detected differentially expressed circRNAs and their target miRNA candidates, and RT-qPCR was performed to detect expression of circ_002117, microRNA (miRNA)-370 and HERPUD1 in gastric cancer tissues and cells. Gastric cancer cells were transfected with plasmids and their proliferative ability and apoptosis were detected with gain- and loss-of-function assay. The ER of treated cells was observed under a transmission electron microscope. Dual-luciferase reporter gene assay and RIP were performed to detect the interaction between HEPRUD1, miR-370 and circ_002117-treated cells were injected into mice to establish xenograft tumor model. Results Circ_002117 and HEPRUD1 were poorly expressed whereas miR-370 was highly expressed in clinical cancer tissues and cells. Circ_002117 was indicated to target and suppress miR-370 expression, while HERPUD1 was directly targeted by miR-370. Circ_002117 overexpression or miR-370 deficiency promoted ER stress-induced apoptosis and decreased proliferation of gastric cancer cells, which was reversed by silencing of HEPRUD1. Circ_002117 overexpression or miR-370 depletion significantly suppressed gastric cancer tumorigenesis in vivo. Conclusions Taken altogether, circ_002117 facilitated ER stress-induced apoptosis in gastric cancer by upregulating HERPUD1 through miR-370 inhibition.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Circ_002117 binds to microRNA-370 and promotes endoplasmic reticulum stress-induced apoptosis in gastric cancer

et al. 2020

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“…Other than functioning as potential prognosis biomarkers for GC, circR-NAs have also been shown to be associated with the carcinogenesis and aggressive behavior of GC. 9,10 Here, in vitro functional assays revealed that gain-of-function experiments revealed that ectopic expression of circCYFIP2 promoted proliferation and inhibited apoptosis of GC cells. Loss-of-function experiments revealed that knockdown of circCYFIP2 inhibited proliferation and promoted apoptosis of GC cells.…”

Section: Discussionmentioning

confidence: 99%

circCYFIP2 Acts as a Sponge of miR-1205 and Affects the Expression of Its Target Gene E2F1 to Regulate Gastric Cancer Metastasis

Lin

Liao

et al. 2020

Molecular Therapy - Nucleic Acids

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Accumulating evidence suggested that circular RNAs (circR-NAs) play critical roles in the initiation and progression of malignant cancers. However, the roles of circRNAs in gastric cancer (GC) remain largely unknown. In the present study, we investigated the expression of circRNAs in 5 GC tissues with metastasis and 5 GC tissues without metastasis by microarray analysis. We focused on hsa_circ_0003506, which was spliced from CYFIP2 gene located at chr5:156786012-156788606 and finally formed a sense-overlapping circular transcript of 366 nt, and thus we named it circCYFIP2. circCY-FIP2 was found to be significantly upregulated in GC tissues and cell lines. High expression of circCYFIP2 was associated with metastasis and poor prognosis of GC patients. Function assays revealed that overexpression or knockdown of circCY-FIP2 significantly enhanced or reduced GC cell proliferation and invasion abilities. In mechanism, we found that circCY-FIP2 might serve as a competing endogenous RNA (ceRNA) of microRNA-1205 (miR-1205) in GC progression. Besides, E2F1 was found to be a target of miR-1205. Collectively, our findings suggested that circCYFIP2 might serve as an oncogenic circRNA to promote GC progression via the miR-1205/ E2F1 axis, which provided a potential therapeutic target for the treatment of GC.

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“…CircRNAs have been studied in a variety of human tumor types, including those affecting the reproductive and urinary systems, digestive system, nervous system, respiratory system, etc. (17)(18)(19)(20)(21). Currently, the enormous potential for circRNA use in targeted therapy and as a noninvasive biomarker has garnered much attention from the broader scientific community (22).…”

Section: Circrna and Cancermentioning

confidence: 99%

Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma

Liu

Yang

et al. 2020

Front. Oncol.

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Circular RNAs (circRNAs) are endogenous noncoding RNAs that are widely found in eukaryotic cells. They have been found to play a vital biological role in the development of human diseases. At present, circRNAs have been involved in the pathogenesis, diagnosis, and targeted treatment of multiple tumors. This article reviews the research progress of circRNAs in osteosarcoma (OSA) in recent years. The potential connection between circRNAs and OSA cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity or resistance, as well as clinical values, is described in this review. Their categories and functions are generally summarized to facilitate a better understanding of OSA pathogenesis, and findings suggest novel circRNA-based methods may be used to investigate OSA and provide an outlook for viable biomarkers and therapeutic targets.

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CircRBM33 regulates IL-6 to promote gastric cancer progression through targeting miR-149

Cited by 38 publications

References 42 publications

RETRACTED ARTICLE: Circ_002117 binds to microRNA-370 and promotes endoplasmic reticulum stress-induced apoptosis in gastric cancer

RETRACTED ARTICLE: Circ_002117 binds to microRNA-370 and promotes endoplasmic reticulum stress-induced apoptosis in gastric cancer

circCYFIP2 Acts as a Sponge of miR-1205 and Affects the Expression of Its Target Gene E2F1 to Regulate Gastric Cancer Metastasis

Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma

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