circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression

Sun, Yu-Meng; Wang, Wen-Tao; Zeng, Zhan-Cheng; Chen, Tian-Qi; Han, Cai; Pan, Qi; Huang, Wei; Fang, Ke; Sun, Lin-Yu; Zhou, Yufan; Luo, Xue-Qun; Luo, Chengwei; Du, Xin

doi:10.1182/blood.2019000802

Cited by 161 publications

(151 citation statements)

References 60 publications

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“…AML patients carrying a high expression of hsa_circ_0075001 had lower expression of components of the Toll-like receptor signaling pathway, suggesting that this circRNA might be involved in the modulation of the immune response in AML [60]. Another cir-cRNA, circMYBL2, which is derived from the cellcycle checkpoint gene MYBL2, has been reported to be highly expressed in FLT3-ITD mutation-positive AML patients [235]. Depletion of circMYBL2 inhibited proliferation and induced differentiation of FLT3-ITD AML cells in vitro and in vivo [235].…”

Section: Role Of Non-coding Rnas In Immune Modulation In Leukemiamentioning

confidence: 99%

“…Another cir-cRNA, circMYBL2, which is derived from the cellcycle checkpoint gene MYBL2, has been reported to be highly expressed in FLT3-ITD mutation-positive AML patients [235]. Depletion of circMYBL2 inhibited proliferation and induced differentiation of FLT3-ITD AML cells in vitro and in vivo [235]. In a recent study of a comprehensive analysis of circRNA expression during hematopoiesis, the expression of circRNA was found to be highly cell-type specific during hematopoietic differentiation [236].…”

Section: Role Of Non-coding Rnas In Immune Modulation In Leukemiamentioning

confidence: 99%

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Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

et al. 2020

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Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate. Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets.

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Section: Role Of Non-coding Rnas In Immune Modulation In Leukemiamentioning

confidence: 99%

Section: Role Of Non-coding Rnas In Immune Modulation In Leukemiamentioning

confidence: 99%

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

et al. 2020

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“…In addition, circRNAs also act as sponges of proteins, as enhancers or coordinators of proteins, mRNAs and DNAs, and as templates for translation ( Fig. 1) [17,[23][24][25][26][27].…”

Section: Biogenesis and General Functions Of Circrnasmentioning

confidence: 99%

“…CircMYBL2 could directly interact with the PTBP1 protein, which subsequently promotes the expression of FLT3 kinase at the translational level and phosphorylation of FLT3 kinase. These effects are why silencing circMYBL2 reduces proliferation, promotes differentiation and enhances cell sensitivity to quizartinib in FLT3-ITD AML cells [24].…”

Section: Hematopoietic System Cancer: Leukemiamentioning

confidence: 99%

Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

et al. 2020

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Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to manipulate the functions of diverse molecules, including non-coding RNAs, mRNAs, DNAs and proteins, to regulate cell activities in physiology and pathology. Accumulating evidence indicates that circRNAs play critical roles in tumor genesis, development, and sensitivity to radiation and chemotherapy. Radiotherapy and chemotherapy are two primary types of intervention for most cancers, but their therapeutic efficacies are usually retarded by intrinsic and acquired resistance. Thus, it is urgent to develop new strategies to improve therapeutic responses. To achieve this, clarification of the underlying mechanisms affecting therapeutic responses in cancer is needed. This review summarizes recent progress and mechanisms of circRNAs in cancer resistance to radiation and chemotherapy, and it discusses the limitations of available knowledge and potential future directions.

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“…[4,5] CircRNAs dysregulation can act as a tumor suppressor or be oncogenic and circRNAs can regulate cell biological functions including cell proliferation, migration, invasion, cell cycle, autophagy, and apoptosis in tumorigenesis and development. [6][7][8][9][10] Recently, circPVT1 was shown that it could contributed to the progression of lung cancer, hepatocellular carcinoma, and Osteosarcoma. [9][10][11][12][13][14] However, the roles of circPVT1 have not been elucidated in BC.…”

Section: Introductionmentioning

confidence: 99%

CircPVT1 Promotes Bladder Cancer Progression by Acting as a ceRNA for miR-140-3p to Target TRPS1

Chi¹,

Sun²,

Zhao³

et al. 2020

Preprint

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Background: Bladder cancer (BC) is one of the most malignancy tumor in the urinary system. Therefore, further studies are needed to revealed the molecular mechanism of BC progression and development. Previous study demonstrated that the deregulation of circRNAs can regulate cell biological functions in tumorigenesis and development. However, the roles of circPVT1 in BC have not yet been revealed. Materials and methods: The expression level of circPVT1, miR-140-3p, and TRPS1 were measured by RT-PCR in BC tissues and cells; dual luciferase reporter and RIP assay showed that circRNA served as a sponge for miRNA, and miRNA could target mRNA. In vitro, effects of overexpression circPVT1 or sh-circPVT1 can regulate BC cells’ proliferation, migration, invasion were detected by CCK-8 assay, wound healing assay, and transwell assay. Results: Our research demonstrated that the expression of circPVT1 was upregulated in BC tissues and cell lines, and increased in metastatic tissues compared to that of non-metastatic tissues. CircPVT1 sponging miR-140-3p to target TRPS1 was revealed by dual luciferase reporter and RIP assay. In addition, the expression level of miR-140-3p was reduced in BC tumor tissues, and TRPS1 was significantly increased in BC tumor tissues. Pearson correlation analysis showed that miR-140-3p with circPVT1 and TRPS1 as compare with miR-140-3p have a moderately negative correlation, and there was a moderately positive correlation between circPVT1 with TRPS1. Further, cytological studies found that circPVT1 enhance BC cells’ proliferation, migration, and invasion by targeting TRPS1 via miR-140-3p. Conclusion: CircPVT1 plays a tumor enhancement role in BC and that can effectively promote cell proliferation, migration, invasion and EMT by targeting the miR-140-3p/TRPS1 axis. CircPVT1 may be a novel potential treatment and diagnosis biomarker in BC.

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circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression

Abstract: Sun et al identify a circular RNA, circMYBL2, that upregulates FLT3 translation to promote FLT3-ITD acute myeloid leukemia (AML) progression, suggesting a novel therapeutic target for FLT3-ITD AML.

Cited by 161 publications

References 60 publications

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

CircPVT1 Promotes Bladder Cancer Progression by Acting as a ceRNA for miR-140-3p to Target TRPS1

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circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression

Abstract: Sun et al identify a circular RNA, circMYBL2, that upregulates FLT3 translation to promote FLT3-ITD acute myeloid leukemia (AML) progression, suggesting a novel therapeutic target for FLT3-ITD AML.

Cited by 161 publications

References 60 publications

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

CircPVT1 Promotes Bladder Cancer&nbsp;Progression by Acting as a ceRNA for miR-140-3p&nbsp;to Target TRPS1

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CircPVT1 Promotes Bladder Cancer Progression by Acting as a ceRNA for miR-140-3p to Target TRPS1