Circle(s) of Life: The Circadian Clock from Birth to Death

Olejniczak, Iwona; Pilorz, Violetta; Oster, Henrik

doi:10.3390/biology12030383

Cited by 8 publications

(7 citation statements)

References 250 publications

(281 reference statements)

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“…Null mutation of period caused reduced negative geotaxis behavior, neurodegeneration and shortened life span, consistent with a possible causative role for loss of rhythmic function in Drosophila death ( Krishnan et al, 2009 ). Notably, disruptions in circadian rhythms are causally implicated in the #1 heart disease, #2 cancer, and #7 AD causes of death in humans ( Chellappa et al, 2019 ; Olejniczak et al, 2023 ).…”

Section: Markers Occurring Proximal To Deathmentioning

confidence: 99%

Markers and mechanisms of death in Drosophila

Tower

2023

Front. Aging

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Parameters correlated with age and mortality in Drosophila melanogaster include decreased negative geotaxis and centrophobism behaviors, decreased climbing and walking speed, and darkened pigments in oenocytes and eye. Cessation of egg laying predicts death within approximately 5 days. Endogenous green fluorescence in eye and body increases hours prior to death. Many flies exhibit erratic movement hours before death, often leading to falls. Loss of intestinal barrier integrity (IBI) is assayed by feeding blue dye (“Smurf” phenotype), and Smurf flies typically die within 0–48 h. Some studies report most flies exhibit Smurf, whereas multiple groups report most flies die without exhibiting Smurf. Transgenic reporters containing heat shock gene promoters and innate immune response gene promoters progressively increase expression with age, and partly predict remaining life span. Innate immune reporters increase with age in every fly, prior to any Smurf phenotype, in presence or absence of antibiotics. Many flies die on their side or supine (on their back) position. The data suggest three mechanisms for death of Drosophila. One is loss of IBI, as revealed by Smurf assay. The second is nervous system malfunction, leading to erratic behavior, locomotor malfunction, and falls. The aged fly is often unable to right itself after a fall to a side-ways or supine position, leading to inability to access the food and subsequent dehydration/starvation. Finally, some flies die upright without Smurf phenotype, suggesting a possible third mechanism. The frequency of these mechanisms varies between strains and culture conditions, which may affect efficacy of life span interventions.

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Section: Markers Occurring Proximal To Deathmentioning

confidence: 99%

Markers and mechanisms of death in Drosophila

Tower

2023

Front. Aging

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“…It has been proved that the human internal rhythm relies on a bidirectional flow between the main circadian pacemaker (suprachiasmatic nucleus) and the numerous peripheral functional clocks, located in almost all tissues and cells [138]. Notably, at the individual level, the circadian rhythm is not uniform over the course of a lifetime, and numerous changes occur starting from the earlier phases after birth, persisting during adolescence and adulthood and continue to evolve with increasing age [139]. Some aspects of chronoregulation and eating habits also appear largely influenced by cultural/religious features: during the Islamic Ramadan, for instance, Muslims abstain from eating and drinking from dawn to dusk and this fasting is considered a pillar of Islam.…”

Section: Impact Of Culture and Chronobiologymentioning

confidence: 99%

Sleep Pathologies and Eating Disorders: A Crossroad for Neurology, Psychiatry and Nutrition

Mutti,

Malagutti,

Maraglino

et al. 2023

Nutrients

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The intricate connection between eating behaviors and sleep habits is often overlooked in clinical practice, despite their profound interdependence. Sleep plays a key role in modulating psychological, hormonal and metabolic balance and exerting an influence on food choices. Conversely, various eating disorders may affect sleep continuity, sometimes promoting the development of sleep pathologies. Neurologists, nutritionists and psychiatrists tend to focus on these issues separately, resulting in a failure to recognize the full extent of the clinical conditions. This detrimental separation can lead to underestimation, misdiagnosis and inappropriate therapeutic interventions. In this review, we aim to provide a comprehensive understanding of the tangled relationship between sleep, sleep pathologies and eating disorders, by incorporating the perspective of sleep experts, psychologists and psychiatrists. Our goal is to identify a practical crossroad integrating the expertise of all the involved specialists.

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“…One major alteration to which astronauts are subjected during Space missions and which is related to the stressors described above is the disruption of their endogenous biological rhythm generated by the circadian clock (Guo et al, 2014). The circadian clock plays a regulatory role in an optimal adaptation of behavior and physiology to the 24 h Earth's rotation (Olejniczak et al, 2023), thereby generating ~24 h (circadian) rhythms, at the cellular level, in the human body.…”

Section: Introductionmentioning

confidence: 99%

Circadian regulation in aging: Implications for spaceflight and life on earth

et al. 2023

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Alterations in the circadian system are characteristic of aging on Earth. With the decline in physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise in elderly populations. Similar health risks are reported as “red flag” risks among astronauts during and after a long‐term Space exploration journey. However, little is known about the common molecular alterations underlying terrestrial aging and space‐related aging in astronauts, and controversial conclusions have been recently reported. In light of the regulatory role of the circadian clock in the maintenance of human health, we review here the overlapping role of the circadian clock both on aging on Earth and spaceflight with a focus on the four most affected systems: visual, cardiovascular, central nervous, and musculoskeletal systems. In this review, we briefly introduce the regulatory role of the circadian clock in specific cellular processes followed by alterations in those processes due to aging. We next summarize the known molecular alterations associated with spaceflight, highlighting involved clock‐regulated genes in space flown Drosophila, nematodes, small mammals, and astronauts. Finally, we discuss common genes that are altered in terms of their expression due to aging on Earth and spaceflight. Altogether, the data elaborated in this review strengthen our hypothesis regarding the timely need to include circadian dysregulation as an emerging hallmark of aging on Earth and beyond.

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Circle(s) of Life: The Circadian Clock from Birth to Death

Cited by 8 publications

References 250 publications

Markers and mechanisms of death in Drosophila

Markers and mechanisms of death in Drosophila

Sleep Pathologies and Eating Disorders: A Crossroad for Neurology, Psychiatry and Nutrition

Circadian regulation in aging: Implications for spaceflight and life on earth

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