circKIF4A sponges miR-127 to promote ovarian cancer progression

Abstract

Ovarian cancer is a major gynecologic cancer and common cause of gynecologic cancer death worldwide. However, the molecular mechanisms of ovarian cancer progression are still unclear. circular RNAs (circRNAs) are recently reported to be involved in cancer progression regulation but the potential functions of circRNAs in ovarian cancer remains unknown. In this study, we explored the expression of circKIF4A in ovarian cancer tissues. Then, a series of experiments were conducted to investigate how circKIF4A functioned in ovarian cancer in vitro and in vivo . The results revealed that circKIF4A was highly expressed in ovarian cancer tissues. Knockdown of circKIF4A suppressed cell proliferation and migration in ovarian cancer. Subsequent mechanism study revealed that circKIF4A acted as a competitive endogenous RNA (ceRNA) to promoted ovarian cancer progression by sponging miR-127 and upregulated the expression of Junctional adhesion molecule 3 (JAM3). Therefore, circKIF4A could be a novel biomarker and therapeutic target for ovarian cancer.

Impact of Amarogentin on Gastric Carcinoma Cell Multiplication, Apoptosis and Migration via circKIF4A/miR-152-3p

“…circKIF4A is highly expressed in ovarian carcinoma and can promote cancer cell multiplication and metastasis [ 29 ]. It is also up-regulated in bladder cancer and can promote carcinoma cell metastasis [ 30 ].…”

CircKIF4A Enhances Osteosarcoma Proliferation And Metastasis By Sponging MiR-515-5p And Upregulating SLC7A11

“…CircRNAs are highly expressed in cells and tissues, and are potential miRNA sponges for regulating the expressions of various key genes closely relatively to malignant tumor [22]. circKIF4A is signi cant in malignant progression of a variety of tumors [8][9][10][11][12][13]. We tested circKIF4A levels in OS cells and tissues.…”

CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review

“…Outcomes from a larger cohort showed that circ-0001068/miR-28-5p in T cells induced PD1 expression, and this caused in T-cell exhaustion [91]. Circ-KIF4A and circ-0025033 promote OC progression by absorbing miR-127 and miR-184, respectively [92,94]. In 2020, another study was conducted on circ-0025033 that confirmed its role in cell viability, invasion [93].…”

“…Numerous studies have shown that circ-0015756, circ-0002711, hsa-circ-0015326, circ-0001068, circ-0025033 and circ-KIF4A are oncogenic circRNAs with diagnostic and prognostic value in OC [88][89][90][91][92][93][94]. Their function occurs through sponge of corresponding miRNAs.…”