CircITCH: A Circular RNA With Eminent Roles in the Carcinogenesis

Ghafouri‐Fard, Soudeh; Khoshbakht, Tayyebeh; Taheri, Mohammad; Jamali, Elena

doi:10.3389/fonc.2021.774979

Cited by 9 publications

(7 citation statements)

References 39 publications

(43 reference statements)

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“…MiRNA, as a part of the ceRNA network, causes polyadenylation by binding with target sites in the 3'-UTR of mRNA, lowering mRNA stability and interfering with translation to adversely control gene expression (Nawaz et al, 2016). CircRNAs may have biological impacts on tumors by sponging target miRNAs and limiting their function, according to previous studies (Li Y. et al, 2020;Ghafouri-Fard et al, 2021;Su et al, 2022). There is no exception for circ-ITCH.…”

Section: Regulation Mechanism and Role Of Circ-itch In Tumor Diseasesmentioning

confidence: 99%

“…Combining the database (Circular RNA Interactome and circBase) and related literature search, we considered it derived from exons 6-13 (Figure 1), while 7-14 was a writing error in correlative papers. Recently, studies have revealed that circ-ITCH is down-regulated in multiple tumor tissues, and regulates cell proliferation, migration, invasion and apoptosis of malignant tumor, indicating it might be an important tumor suppressor (Li Y. et al, 2020;Ghafouri-Fard et al, 2021;Su et al, 2022). Additionally, the down-regulation can also be seen in the peripheral blood and exosomes of patients.…”

Section: Introductionmentioning

confidence: 99%

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CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases

et al. 2022

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CircRNA E3 ubiquitin protein ligase (ITCH) (circRNA ITCH, circ-ITCH), a stable closed-loop RNA derived from the 20q11.22 region of chromosome 20, is a new circRNA discovered in the cytoplasm in recent decades. Studies have shown that it does not encode proteins, but regulates proteins expression at different levels. It is down-regulated in tumor diseases and is involved in a number of biological activities, including inhibiting cell proliferation, migration, invasion, and promoting apoptosis. It can also alter disease progression in non-tumor disease by affecting the cell cycle, inflammatory response, and critical proteins. Circ-ITCH also holds a lot of promise in terms of tumor and non-tumor clinical diagnosis, prognosis, and targeted therapy. As a result, in order to aid clinical research in the hunt for a new strategy for diagnosing and treating human diseases, this study describes the mechanism of circ-ITCH as well as its clinical implications.

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Section: Regulation Mechanism and Role Of Circ-itch In Tumor Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases

et al. 2022

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“…MiR‐214 was also shown to be reduced by the lncRNA, MEG3 (J. Zhang et al, 2017). MiR‐214 and miR‐199a act as sponges for circular RNA‐ITCH; circular RNA‐ITCH is involved in the PTEN/PI3K/AKT and Wnt/β‐catenin pathways implicated in NAFLD fibrosis (El‐Derany & El‐Demerdash, 2020; Ghafouri‐Fard et al, 2021; Riaz et al, 2021).…”

Section: Exosomal Mirnas Involved In Fibrosis Of Nalfd As a Biomarkermentioning

confidence: 99%

The role of exosomal miRNA in nonalcoholic fatty liver disease

Mahmoudi

Butler

Jamialahmadi

et al. 2022

Journal Cellular Physiology

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Nonalcoholic fatty liver disease (NAFLD) impacts more than one‐third of the population and is linked with other metabolic diseases. The term encompasses a wide spectrum of diseases, from modest steatosis to nonalcoholic steatohepatitis, fibrosis and, ultimately, cirrhosis with the potential for development of hepatocellular carcinoma. Currently, available methods for diagnosing NAFLD are invasive or lack accuracy, and monitoring to determine response to therapeutic interventions is challenging. Exosomes are nano‐scaled extracellular vesicles that are secreted by a variety of cells. They convey proteins, mRNA, miRNA, and other bioactive molecules between cells and are involved in an extensive range of biological processes, particularly cell‐cell communication. Several reports suggest that exosomes mediate miRNAs and, thus, they have potential clinical utility for diagnosis, prognosis, and therapeutics in liver diseases. In view of the vital role of exosomal microRNA in disease, we here synthesized current knowledge about the biogenesis of exosomal miRNA and exosome‐mediated microRNA transfer. We then discuss the potential of exosomal miRNA in diagnosis and therapeutics of NAFLD.

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“…Therefore, the sponging of target miRNAs by circITCH regulates ITCH levels. The presence of circITCH in cells leads to an increase in ITCH mRNA levels resulting in greater ITCH ubiquitin activity, which decreases the activity of oncogenic factors [ 129 ]. In CRC, the expression of circITCH was downregulated in cancerous cells, resulting in low levels of ITCH gene expression.…”

Section: Circular Rnasmentioning

confidence: 99%

Context-Dependent Regulation of Gene Expression by Non-Canonical Small RNAs

Plawgo

Raczyńska

2022

ncRNA

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In recent functional genomics studies, a large number of non-coding RNAs have been identified. It has become increasingly apparent that noncoding RNAs are crucial players in a wide range of cellular and physiological functions. They have been shown to modulate gene expression on different levels, including transcription, post-transcriptional processing, and translation. This review aims to highlight the diverse mechanisms of the regulation of gene expression by small noncoding RNAs in different conditions and different types of human cells. For this purpose, various cellular functions of microRNAs (miRNAs), circular RNAs (circRNAs), snoRNA-derived small RNAs (sdRNAs) and tRNA-derived fragments (tRFs) will be exemplified, with particular emphasis on the diversity of their occurrence and on the effects on gene expression in different stress conditions and diseased cell types. The synthesis and effect on gene expression of these noncoding RNAs varies in different cell types and may depend on environmental conditions such as different stresses. Moreover, noncoding RNAs play important roles in many diseases, including cancer, neurodegenerative disorders, and viral infections.

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CircITCH: A Circular RNA With Eminent Roles in the Carcinogenesis

Cited by 9 publications

References 39 publications

CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases

CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases

The role of exosomal miRNA in nonalcoholic fatty liver disease

Context-Dependent Regulation of Gene Expression by Non-Canonical Small RNAs

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