circIGHG-Induced Epithelial-to-Mesenchymal Transition Promotes Oral Squamous Cell Carcinoma Progression via miR-142-5p/IGF2BP3 Signaling

Liu, Jingpeng; Jiang, Xiao; Zou, Ailing; Mai, Zhaoyi; Huang, Zhijie; Sun, Li‐Ying; Zhao, Jianjiang

doi:10.1158/0008-5472.can-20-0554

Cited by 72 publications

(67 citation statements)

References 50 publications

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“…For example, the expression level of circIGHG was found to be significantly upregulated in OSCC tissues compared to adjacent non‐tumor tissues and was positively associated with EMT phenotype. It was further found that circIGHG induced EMT program via targeting miR‐142‐5p and thus, promoted OSCC progression [ 111 ]. Emerging evidence also suggested that EMT, particularly EMT‐TFs, could affect the development of tumor drug resistance.…”

Section: Functions and Mechanisms Of Ncrnas In Drug Resistance Of Osccmentioning

confidence: 99%

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Meng¹,

Lou

Yang³

et al. 2021

Cancer Communications

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Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid. Chemotherapeutic agents such as cisplatin, 5‐fluorouracil, and paclitaxel have now become the first‐line options for OSCC patients. Nevertheless, most OSCC patients eventually acquire drug resistance, leading to poor prognosis. With the discovery and identification of non‐coding RNAs (ncRNAs), the functions of dysregulated ncRNAs in OSCC development and drug resistance are gradually being widely recognized. The mechanisms of drug resistance of OSCC are intricate and involve drug efflux, epithelial‐mesenchymal transition, DNA damage repair, and autophagy. At present, strategies to explore the reversal of drug resistance of OSCC need to be urgently developed. Nano‐delivery and self‐cellular drug delivery platforms are considered as effective strategies to overcome drug resistance due to their tumor targeting, controlled release, and consistent pharmacokinetic profiles. In particular, the combined application of new technologies (including CRISPR systems) opened up new horizons for the treatment of drug resistance of OSCC. Hence, this review explored emerging regulatory functions of ncRNAs in drug resistance of OSCC, elucidated multiple ncRNA‐meditated mechanisms of drug resistance of OSCC, and discussed the potential value of drug delivery platforms using nanoparticles and self‐cells as carriers in drug resistance of OSCC.

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Section: Functions and Mechanisms Of Ncrnas In Drug Resistance Of Osccmentioning

confidence: 99%

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Meng¹,

Lou

Yang³

et al. 2021

Cancer Communications

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“…circIGHG was also found to promote EMT in vivo through xenograft tumors. Finally, circIGHG promoted OSCC metastasis via inducing IGF2BP3-mediated EMT by sponging miR-142-5p ( 149 ).…”

Section: Roles Of Circrnas In Human Cancermentioning

confidence: 99%

Circular RNAs in Human Cancer

Wang

et al. 2021

Front. Oncol.

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Circular RNAs (circRNAs) are a class of endogenous single-stranded covalently closed RNAs, primarily produced from pre-mRNAs via non-canonical back-splicing. circRNAs are highly conserved, stable, and expressed in tissue- and development-specific pattern. circRNAs play essential roles in physiological process as well as cancer biology. By the advances of deep sequencing and bioinformatics, the number of circRNAs have increased explosively. circRNAs function as miRNA/protein sponge, protein scaffold, protein recruitment, enhancer of protein function, as well as templates for translation involved in the regulation of transcription/splicing, translation, protein degradation, and pri-miRNA processing in human cancers and contributed to the pathogenesis of cancer. Numerous circRNAs may function in diverse manners. In this review, we survey the current understanding of circRNA functions in human cancer including miRNA sponge, circRNA-protein interaction, and circRNA-encoded protein, and summarize available databases for circRNA annotation and functional prediction.

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“…In OSCC, aberrant expression of circular RNAs (circRNAs) plays a role. For instance, Jingpeng Liu and coworkers [21] showed that circIGHG, an immunoglobulin heavy chain G (IGHG)-derived circRNA, is highly expressed in OSCC, which leads to the invasion and metastasis of OSCC via the microRNA (miR)-142-5p/insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) pathway when inducing EMT.…”

Section: Elucidation Of Biomarkers In Osccmentioning

confidence: 99%

The integration of differentially expressed genes based on multiple microarray datasets for prediction of the prognosis in oral squamous cell carcinoma

2021

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Oral squamous cell carcinoma (OSCC) is a common human malignancy. However, its pathogenesis and prognostic information are poorly elucidated. In the present study, we aimed to probe the most significant differentially expressed genes (DEGs) and their prognostic performance in OSCC. Multiple microarray datasets from the Gene Expression Omnibus (GEO) database were aggregated to identify DEGs between OSCC tissue and control tissue. Least absolute shrinkage and selection operator (LASSO) Cox model was constructed to determine the prognostic performance of the aggregated DEGs based on The Cancer Genome Atlas (TCGA) OSCC cohort. Ten datasets with 341 OSCC samples and 283 control samples were included. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment revealed that the integrated DEGs were enriched in the IL-17 signaling pathway, viral protein interactions with cytokines and cytokine receptors, and amoebiasis, among others. Our LASSO Cox model was able to discriminate two groups with different overall survival in the training cohort and test cohort (p < 0.001). The time-dependent receiver operating characteristic (ROC) curve revealed that the area under the curve (AUC) values at one year, three years, and five years were 0.831, 0.898, and 0.887, respectively. In the testing cohort, the time-dependent ROC curve showed that the AUC values at one year, three years, and five years were 0.696, 0.693, and 0.860, respectively. Our study showed that the integrated DEGs of OSCC might be applicable in the evaluation of prognosis in OSCC. However, further research should be performed to validate our findings.

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circIGHG-Induced Epithelial-to-Mesenchymal Transition Promotes Oral Squamous Cell Carcinoma Progression via miR-142-5p/IGF2BP3 Signaling

Cited by 72 publications

References 50 publications

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Circular RNAs in Human Cancer

The integration of differentially expressed genes based on multiple microarray datasets for prediction of the prognosis in oral squamous cell carcinoma

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