circFAT1(e2) Promotes Papillary Thyroid Cancer Proliferation, Migration, and Invasion via the miRNA-873/ZEB1 Axis

Liu, Jiazhe; Li, Hongchang; Wei, Chuanchao; Ding, Jian; Lu, Jingfeng; Pan, Gaofeng; Mao, Anwei

doi:10.1155/2020/1459368

Cited by 21 publications

(19 citation statements)

References 33 publications

(32 reference statements)

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“…This effect is also commonly observed in TC: CircFAT1 (e2) has a function similar to that of CIRS-7 and has a binding site for miR-873. CircFAT1 is highly expressed in PTC tissues and cells and serves as an miRNA sponge to vastly downregulate miR-873 expression, thus upregulating the activity of zinc finger E-box binding homeobox 1 and ultimately promoting the growth, migration and invasion of PTC cells ( 34 ).…”

Section: Functions Of Circrnasmentioning

confidence: 99%

CircRNA: A novel potential strategy to treat thyroid cancer (Review)

et al. 2021

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Thyroid cancer (TC) is the most common type of endocrine cancer. Over the last 50 years, the global incidence of TC has been increasing. The survival rate of TC is higher than that of most other types of cancer, but it depends on numerous factors, including the specific type of TC and stage of the disease. Circular RNAs (circRNAs) are a new class of long noncoding RNA with a closed loop structure that have a critical role in the complex gene regulatory network that controls the emergence of TC. The most important function of circRNAs is their ability to specifically bind to microRNAs. In addition, the biological functions of circRNAs also include interactions with proteins, regulation of the transcription of genes and acting as translation templates. Based on the characteristics of circRNAs, they have been identified as potential biomarkers for the diagnosis of tumors. In the present review, the function and significance of circRNAs and their potential clinical implications for TC were summarized. Furthermore, possible treatment approaches involving the use of mesenchymal stem cells (MSCs) and exosomes derived from MSCs as carriers to load and transport circRNAs were discussed.

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Section: Functions Of Circrnasmentioning

confidence: 99%

CircRNA: A novel potential strategy to treat thyroid cancer (Review)

et al. 2021

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“…Previous studies have shown that circFAT1(e2) is a new circRNA derived from exon 2 of the FAT1 gene [ 16 ]. In PTC, circFAT1(e2) plays a carcinogenic effect by promoting cell invasion and metastasis and is a potential new target for PTC therapy [ 17 ]. It is found in gastric cancer (GC) that the overexpression of circFAT1(e2) inhibits the proliferation, migration, and invasion of GC cells and is related to the overall survival rate of GC patients [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

circRNA circFAT1(e2) Elevates the Development of Non-Small-Cell Lung Cancer by Regulating miR-30e-5p and USP22

Dong

Zhang

Dai

et al. 2021

BioMed Research International

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Background. As a newly discovered regulatory RNA, circular RNA (circRNA) has become a hot spot in many tumor pieces of research. In recent years, it has been discovered that circRNAs have multiple biological effects in different stages of cancer. However, the expression pattern and mechanism of circFAT1(e2) in non-small-cell lung cancer (NSCLC) are still unclear. Methods. The expressions of circFAT1(e2) in NSCLC tissues and cell lines were studied. Functionally, CCK-8 and transwell experiments were performed in A549 and H1299. In addition, we also performed a dual-luciferase report analysis to clarify the mechanism of action of circFAT1(e2). Results. circFAT1(e2) was significantly upregulated in NSCLC tissues and cell lines. circFAT1(e2) gene knockdown could significantly inhibit the proliferation, migration, and invasion of NSCLC cells. Loss of function testing found that circFAT1(e2) functioned as an oncogene in NSCLC cells. In addition, circFAT1(e2) acted as a ceRNA to spongy miR-30e-5p, which led to the increase in USP22 and promoted cell growth. Conclusions. The circFAT1(e2)-miR-30e-5p-USP22 axis is a crucial part of the progression of NSCLC. This study suggests that circFAT1(e2) may be an important potential of prognostic prediction and treatment targets for NSCLC patients.

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“…Therefore, if tissue circFAT1 expression levels in a biopsy sample or resected specimen are low, additional treatments need to be considered, even for patients with early-stage cancer. Evidence is accumulating to show that circFAT1 exerts both tumor-promoting 17,[20][21][22] and tumor-suppressive effects. 18,19 Tumor-suppressive effects have been reported for adenocarcinomas of the gastrointestinal tract, 18,19 but not for squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Its expression and oncological significance were initially reported for osteosarcoma in 2018 17 and subsequent studies reported similar findings for other cancer types. CircFAT1 functions as a tumor promoter or suppressor in specific cancers by sponging miRNAs and repressing their downstream pathways; [18][19][20][21][22] however, it has not yet been reported as a prognostic biomarker in any cancers. The present study investigated the biological function of circFAT1 and its potential as a prognostic biomarker in ESCC.…”

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confidence: 99%

Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma

et al. 2021

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Background Circular RNA is a novel endogenous non-coding RNA with a stable loop structure, and theories for its biogenesis and usefulness as a biomarker in various cancers have been proposed. The present study investigated the significance of circular FAT1 (circFAT1) as a novel biomarker in esophageal squamous cell carcinoma (ESCC). Method CircFAT1 expression levels were measured in ESCC cell lines and the effects of downregulating circFAT1 on cell migration and invasion were examined using a transwell assay. The functions of miR-548g, which will be sponged by circFAT1, were assessed. Furthermore, the expression of circFAT1 was evaluated in 51 radically resected ESCC tissue samples using quantitative reverse transcription polymerase chain reaction (qRT-PCR). The relationships between circFAT1 expression, clinicopathological factors, and patient prognosis were analyzed. Results CircFAT1 expression levels were significantly lower in tumor tissue than in adjacent non-tumorous mucosal tissue (p = 0.01). The downregulation of circFAT1 expression promoted ESCC cell migration and invasive ability, but not proliferation. The expression of miR-548g was upregulated by the downregulation of circFAT1. The overexpression of miR-548g also promoted ESCC cell migration and invasion. Recurrence-free survival (p = 0.02) and cancer-specific survival (p = 0.04) rates were significantly higher in patients with elevated circFAT1 expression levels. Conclusion The expression level of circFAT1 is a novel prognostic marker in ESCC patients. New treatment strategies may be developed using the tumor suppressive functions of circFAT1.

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circFAT1(e2) Promotes Papillary Thyroid Cancer Proliferation, Migration, and Invasion via the miRNA-873/ZEB1 Axis

Cited by 21 publications

References 33 publications

CircRNA: A novel potential strategy to treat thyroid cancer (Review)

CircRNA: A novel potential strategy to treat thyroid cancer (Review)

circRNA circFAT1(e2) Elevates the Development of Non-Small-Cell Lung Cancer by Regulating miR-30e-5p and USP22

Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma

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