Circadian variations in the renal toxicity of gentamicin in rats

Pariat, Claudine; Courtois, Philippe; Cambar, J.; Piriou, Alain; Bouquet, S.

doi:10.1016/0378-4274(88)90159-2

Cited by 50 publications

(28 citation statements)

References 12 publications

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“…In animals, higher peak serum levels of aminoglycosides [51][52][53] were found when these drugs were injected during the middle of the rest period. Similar results were observed in the renal levels of these drugs [49,51,[53][54][55]. Table 2 also shows that the maximal serum clearance of aminoglycosides was found when these antibiotics were injected during the middle of the activity period in rodents [52,[56][57][58].…”

Section: Pharmacokinetics Of Antibiotics: Effect Of Physical Activitysupporting

confidence: 81%

Pharmacologic basis for the treatment of pyelonephritis

Beauchamp

Bergeron²

1999

Curr Infect Dis Rep

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Urinary tract infections (UTIs) are among the most common bacterial infections in humans. Even though physicians have been treating UTIs for 60 years, there has been no standardized approach regarding the rational choice of antimicrobial agents and optimal treatment duration for these infections. This review discusses the pharmacologic basis for the treatment of UTIs. Although most antibiotics concentrate well in the urine and can eradicate most of the sensitive uropathogens that cause lower UTI, antibiotics given for the treatment of pyelonephritis must concentrate and kill bacteria embedded within the renal parenchyma. Investigators once believed that antibiotics must concentrate in sufficient amounts in the urine of infected patients to be effective in treating pyelonephritis. In fact, the efficacy of an antibiotic in the treatment of pyelonephritis is proportional to its capacity to converge in high concentration not only in urine but also in the renal parenchyma because serum and urine levels of antibiotics are poor predictors of the intrarenal levels. Other factors should also be taken into consideration in the management of UTIs, such as the time of day antibiotics are given because significant time-dependent differences have been observed in the pharmacokinetics and rate of excretion in urine of several antibiotics. Finally, the authors review the recent development in the inflammatory response in the urinary tract that may explain the clinical features of UTI and may be useful in the diagnosis as well as better management of UTI.

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Section: Pharmacokinetics Of Antibiotics: Effect Of Physical Activitysupporting

confidence: 81%

Pharmacologic basis for the treatment of pyelonephritis

Beauchamp

Bergeron²

1999

Curr Infect Dis Rep

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“…The following investigation confirmed this finding, indicating the circadian rhythm in the susceptibility of mice to other aminoglycosides , and showed great similarity in their chronotoxicity ( Soulban et al , 1986 ;Pariat et al, 1984 ;Fisch et al, 1984 ;Pariat et al, 1986 ). The circadian stage -dependent changes in gentamicin kinetics has been reported in rats ( Lakatua et al , 1986 ) .…”

Section: Introductionsupporting

confidence: 60%

Annual Review of Chronopharmacology. Volume 7. Biological Rhythms and Medications. Proceedings of the Conference of Chronopharmacology Held in Nice, France on 12-15 March 1990

Reinberg¹,

Smolensky²,

Labrecque³

1990

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“…Injections of GM were made daily at 0800 to minimize the circadian variation in nephrotoxicity (Pariat et al, 1988). At the end of treatment, all animals were rapidly stunned and decapitated.…”

Section: Treatmentsmentioning

confidence: 99%

Nephroprotective Action ofPhoenix dactylifera. in Gentamicin-Induced Nephrotoxicity

Alqarawi

Abdel-Rahman

Mousa

et al. 2008

Pharmaceutical Biology

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We investigated the effect of an extract of the flesh and pits of dates [Phoenix dactylifera L (Arecaceae or Palmae)] on gentamicin (GM) nephrotoxicity in rats. The animals were given either the date flesh extract mixed with the food (50% w/w) or the pits extract mixed in the drinking water (2:1 w/v), and GM (80 mg kg −1 day −1 intramuscularly for 6 days) was injected during the last 6 days of treatment. Other groups of rats were given GM concomitantly with the date flesh extract or the date pits extract at the above doses. GM treatment significantly increased the plasma concentrations of creatinine and urea and induced a marked necrosis of the renal proximal tubules. The date flesh and pits were effective in significantly reducing the increases in plasma creatinine and urea concentrations induced by GM nephrotoxicity and ameliorating the proximal tubular damage. Antioxidant components in the date (e.g., melatonin, vitamin E, and ascorbic acid) were suggested to be the basis of the nephroprotection.

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Circadian variations in the renal toxicity of gentamicin in rats

Cited by 50 publications

References 12 publications

Pharmacologic basis for the treatment of pyelonephritis

Pharmacologic basis for the treatment of pyelonephritis

Annual Review of Chronopharmacology. Volume 7. Biological Rhythms and Medications. Proceedings of the Conference of Chronopharmacology Held in Nice, France on 12-15 March 1990

Nephroprotective Action ofPhoenix dactylifera. in Gentamicin-Induced Nephrotoxicity

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