Circadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain

Ayers, Nancy A.; Kapás, Levente; Krueger, James M.

doi:10.1016/0006-8993(95)01362-8

Cited by 62 publications

(50 citation statements)

References 18 publications

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“…The highest level occurred during the dark period and the lowest level occurred during the light period. 98 In addition, NOS activation mediated the phaseshifting effects of melatonin and 5-hydroxytryptamine on a suprachiasmatic nuclei (SCN) circadian pacemaker in rats. 99 Moreover, as key regulators of the circadian timing process, miRNA-219 and miRNA-132 levels in SCN exhibited a salient rhythm, the highest level of which occurred during the subjective day.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

Shui

Wang

Chiang

et al. 2015

Exp Biol Med (Maywood)

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Physical therapy (physiotherapy), a complementary and alternative medicine therapy, has been widely applied in diagnosing and treating various diseases and defects. Increasing evidence suggests that convenient and non-invasive far-infrared (FIR) rays, a vital type of physiotherapy, improve the health of patients with cardiovascular disease, diabetes mellitus, and chronic kidney disease. Nevertheless, the molecular mechanisms by which FIR functions remain elusive. Hence, the purpose of this study was to review and summarize the results of previous investigations and to elaborate on the molecular mechanisms of FIR therapy in various types of disease. In conclusion, FIR therapy may be closely related to the increased expression of endothelial nitric oxide synthase as well as nitric oxide production and may modulate the profiles of some circulating miRNAs; thus, it may be a beneficial complement to treatments for some chronic diseases that yields no adverse effects.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

Shui

Wang

Chiang

et al. 2015

Exp Biol Med (Maywood)

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“…In particular, the use of voltammetry led to the proposal that, in the rat, the release of 5-HT would occur according to two modalities, from the axonal endings during waking and from the dendrites and/or cell bodies during sleep (Cespuglio et al 1992). On the other hand, the production of NO might also be correlated to the alternating pattern of sleeping and waking, since the enzymatic activity of NOS is highest everywhere in the rat brain when the animals are awake (Ayers et al 1996) and NO itself is detected in higher quantities in the cortex during waking (Burlet and Cespuglio 1997). Since there are indications that NO would favor the release of 5-HT (Lorrain and Hull 1993) and inhibits its reuptake (Pögün and Kuhar 1994), it can be hypothesized that NO might serve as an amplification signal for 5-HT across the sleep-wake cycle, at least in the areas of serotoninergic terminals.…”

Section: Discussionmentioning

confidence: 98%

Comparative distribution of nitric oxide synthase- and serotonin-containing neurons in the raphe nuclei of four mammalian species

Léger

Charnay²,

Burlet

et al. 1998

Histochemistry and Cell Biology

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Monoclonal antibodies were generated against serotonin (5-HT) and the C-terminal portion of the neuronal form of nitric oxide synthase (nNOS), the enzyme producing nitric oxide in neurons. These antibodies were used to compare the distribution of 5-HT- and nNOS-containing neurons in the raphe nuclei of four animal species (rat, mouse, guinea pig, and cat). It was found that the rat was the only species in which the raphe nuclei contain a substantial number of nNOS-immunoreactive (IR) cell bodies. In this species and as observed by other authors, all mesencephalic raphe nuclei contained nNOS-IR cells, the largest group being located in the nucleus raphe dorsalis. The coexistence of nNOS and 5-HT immunoreactivities in these nuclei was visualized by double labeling. In the medulla, the nuclei raphe magnus and obscurus displayed a rather low number of nNOS-IR neurons. In the other species, nNOS-IR cell bodies were found in very low numbers, whatever raphe nucleus was considered. The rostral pole of the nucleus raphe dorsalis and the nuclei raphe magnus and obscurus contained a few nNOS-IR neurons which did not show any coincidence with the 5-HT neurons. In addition, nNOS-IR axons were rare. It is concluded that in the mouse, guinea pig, and cat the involvement of nitric oxide in functions subserved by 5-HT within the raphe nuclei might be minimal.

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“…Nitric oxide synthase activity has been reported to change in the hypothalamus with circadian rhythm (Ayers et al 1996). Vasopressin mRNA levels also change with circadian rhythm as early as E21 in the suprachiasmatic nucleus but not in the SO (Reppert and Uhl 1987).…”

Section: Circadian Rhythmmentioning

confidence: 98%

Ontogeny of NADPH-diaphorase in rat forebrain and midbrain

Iwase

Takemura

Shimada

et al. 1998

Anatomy and Embryology

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This study characterizes the developmental expression of NADPH-diaphorase from embryo to adulthood in the forebrain, midbrain and cerebellum of rat brain via histochemical staining. On embryonic day 12 no neurons stained. Labeling was observed in certain nuclei from E15 through the postnatal period to adulthood. Labeling in neurons increased or maintained a constant level with increased age. The embryo demonstrated substantial labeling in neurons of the caudate putamen, bed nucleus of the stria terminalis, preoptic area, lateral hypothalamic area, paraventricular thalamic nucleus, ventromedial hypothalamic nucleus, magnocellular nucleus posterior commissure, and periaqueductal central gray. Additional neuronal labeling was observed postnatally in the olfactory bulb, cerebral cortex, amygdala, various nuclei of the thalamus, interpeduncular nucleus, linear nucleus of the raphe, pretectal area and superior colliculus. In the cerebellum, labeling appeared only after P14 in cells of the molecular cell layer and granular cell layer. The sizes of labeled neurons developed significantly from P4 to P14 in several nuclei. The distinctive temporal and spatial expression pattern of NADPH-diaphorase implies that the NO/cGMP system may play an important role in physiological and developmental functions.

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Circadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain

Cited by 62 publications

References 18 publications

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

Comparative distribution of nitric oxide synthase- and serotonin-containing neurons in the raphe nuclei of four mammalian species

Ontogeny of NADPH-diaphorase in rat forebrain and midbrain

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