Circadian Variation in the Response to Vaccination: A Systematic Review and Evidence Appraisal
Cathy A. Wyse,
Laura M. Rudderham,
Enya A. Nordon
et al.
Abstract:Molecular timing mechanisms known as circadian clocks drive endogenous 24-h rhythmicity in most physiological functions, including innate and adaptive immunity. Consequently, the response to immune challenge such as vaccination might depend on the time of day of exposure. This study assessed whether the time of day of vaccination (TODV) is associated with the subsequent immune and clinical response by conducting a systematic review of previous studies. The Cochrane Library, PubMed, Google, Medline, and Embase … Show more
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