Circadian variation in the propagation velocity of the migrating motor complex

Kumar, Devinder; Wingate, David; Ruckebusch, Y.

doi:10.1016/0016-5085(86)90696-7

Cited by 128 publications

(49 citation statements)

References 19 publications

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“…42 Conversely, circadian rhythms strongly impact on the treatment of cancer, because the toxicity of many anticancer drugs varies markedly with the time of administration. 43 The expression of clock genes in the myenteric plexus of the ENS 22 resonates with early observations by Bünning, 44 who noticed a circadian rhythm in the amplitude of contractions of an isolated piece of hamster gut in vitro, and Kumar et al, 45 who found in three species, including human, that the propagation velocity of the migrating motor complex (MMC; an ENS-mediated phenomenon 46 ) varied strongly between day and night, following a sinusoidal pattern (see below). However, a limitation of all studies on the expression of clock genes in the gut so far is that analyses were performed on either whole tissues [22][23][24] or cell fractions enriched in Paneth ⁄ crypt base Fig.…”

Section: Oscillators In the Gi Tractsupporting

confidence: 77%

“…[69][70][71] This is due to the continuous flow of contents from the stomach(s) of these animals to the small intestine. The fact that Kumar et al 45 observed strong circadian variation of the propagation velocity of the MMC suggests that at least some aspects of the MMC are modulated by clock gene oscillations, although the underlying mechanisms clearly need to be investigated. The speciesspecific differences in this ENS-controlled GI functional property may be connected to how an animal's feeding strategy entrains peripheral (including ENS and other intestinal) clocks.…”

Section: Animal Modelsmentioning

confidence: 97%

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Rhythm of digestion: keeping time in the gastrointestinal tract

Bron

Furness

2009

Clin Exp Pharma Physio

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1. The best characterized mammalian circadian rhythms follow a light-entrained central master pacemaker in the suprachiasmatic nucleus and are associated with fluctuations in the activities of clock genes, including Clock, Bmal1, Per and Cry, the products of which bind to sequences in the promoters of effector genes. This is the central clock. 2. In the present review, we discuss evidence for an independent, but interacting, gut-associated circadian clock, the peripheral clock, which is entrained by food. 3. Disruption of circadian rhythms is associated with a wide range of pathologies, most prominently metabolism linked, but the effects of disruption of circadian rhythms on the digestive system are less well studied, although also likely to lead to functional consequences. There are clues suggestive of links between gastrointestinal disorders related to inflammation, cancer and motility and disruption of peripheral rhythms. Research aimed at understanding these links is still in its infancy. 4. We also discuss practical aspects of the presence of circadian rhythms in gastrointestinal tissues for researchers related to experimental design, data interpretation and the choice of animal models. 5. There is currently sufficient evidence to suggest that circadian rhythms are important to gut function, metabolism and mucosal defence and that further investigation will uncover connections between disordered rhythms and gastrointestinal malfunction.

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Section: Oscillators In the Gi Tractsupporting

confidence: 77%

Section: Animal Modelsmentioning

confidence: 97%

Rhythm of digestion: keeping time in the gastrointestinal tract

Bron

Furness

2009

Clin Exp Pharma Physio

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“…Significant time-dependent changes have been documented in motility (2,3), absorption rates (4,5), mucosal enzyme activities (6), and gastric acid secretion (7). This review focuses mainly on cell proliferation rhythms of the gastrointestinal tract mucosa since this has implication for cancer chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Rhythms in Human Gastrointestinal Mucosa and Skin

Bjarnason

Jordan

2002

Chronobiology International

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Rhythmicity in cell proliferation is well established in the gastrointestinal tract and skin, both in rodents and humans. This is the basis for studies on the timing of both chemotherapy and radiotherapy. More recently, circadian rhythm studies of cell-cycle proteins have confirmed earlier findings based on thymidine labeling and flow cytometry. The genetic control of circadian rhythms has been elucidated recently and a possible connection between the circadian clock and the timing of cell-cycle events has been suggested. The data for gastrointestinal mucosa and skin are reviewed and the potential clinical implications of these results are discussed.

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“…It has been reported that the gastric emptying time is shorter in the morning than in the evening (1,2), and that the transportation velocity of the small bowel (3), as well as the excretion of gastrointestinal regulatory peptides (4)(5)(6), depend on the time of the day. Circadian variation in the gallbladder responsiveness to various stimuli was reported in the 1950s (7), but systematic investigations of this topic are lacking.…”

Section: Introductionmentioning

confidence: 99%

Circadian Variations in the Responsiveness of Human Gallbladder to Sulfated Mineral Water

Gutenbrunner

El-Cherid

Gehrke

et al. 2001

Chronobiology International

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It is well known that the intake of sulfate-containing natural mineral waters leads to contraction of the gallbladder, probably induced by the release of cholecystokinin (CCK). As early as 1959, there were some hints in the literature of circadian variations in gallbladder response; to find out whether this applies with sulfate as a stimulus, a pretest for basic information about gallbladder reaction to sulfate-containing mineral water was carried out on 19 healthy volunteers. On this basis, 15 healthy subjects of both sexes were then studied. After 6h of fasting, 500 mL of a sulfate-containing mineral water (2,800 mg SO4(2-)/L) were ingested within 5 min. The size of the gallbladder was registered ultrasonographically before and 15, 30, 60, and 120 min after drinking. The experiments were carried out seven times at different hours of the day for each volunteer. After the intake of the mineral water, the mean gallbladder size decreased significantly, followed by an increase after 60 min (P < .001). Significant circadian spontaneous variation in gallbladder size was detected (acrophase around 09:00; amplitude was 30.0% of daily average, P < .001). The contraction induced by the sulfate-containing water was most marked in the early morning hours and minimal around mid-day; the amplitude of this variation accounting for 29.0% of the daily average (P < .01). In contrast, the postdrinking relaxation was maximal around 18:00 and minimal around 9:00 (amplitude 38.5%. P < .001). These results show that the basal size of the gallbladder and its reaction to stimuli show a marked circadian variation: Whereas contractibility is maximal in the morning, dilatation is stronger in the afternoon.

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Circadian variation in the propagation velocity of the migrating motor complex

Cited by 128 publications

References 19 publications

Rhythm of digestion: keeping time in the gastrointestinal tract

Rhythm of digestion: keeping time in the gastrointestinal tract

Rhythms in Human Gastrointestinal Mucosa and Skin

Circadian Variations in the Responsiveness of Human Gallbladder to Sulfated Mineral Water

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