Circadian variation in platelet function in healthy volunteers

Jafri, Syed M.; VanRollins, Mike; Ozawa, Tsunenori; Mammen, Eberhard F.; Goldberg, A.David; Goldstein, Sidney

doi:10.1016/0002-9149(92)90799-5

Cited by 81 publications

(58 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Arachidonic acid. ADP and 5-HT-induced platelet aggregation showed a gradual increase dur ing the day in agreement with other reports [13,14], Platelet aggregation in urcmics was expectedly lower, and did show diurnal vari ation in response to ADP. In this case, how ever, aggregation peaked at a different time than in controls.…”

supporting

confidence: 92%

Altered Circadian Rhythm of Platelet Aggregation in Hemodialyzed Patients

Rydzewski

Małyszko

Borawski

et al. 1997

Nephron

View full text Add to dashboard Cite

supporting

confidence: 92%

Altered Circadian Rhythm of Platelet Aggregation in Hemodialyzed Patients

Rydzewski

Małyszko

Borawski

et al. 1997

Nephron

View full text Add to dashboard Cite

“…Previous studies of D-dimer on a small number of subjects (nϽ15) did not find a diurnal variation in D-dimer, 24,25 although another small study did report a morning peak. 26 The present study is the first to report a diurnal pattern in CRP, which was not observed in a previous study of only 13 healthy young volunteers.…”

Section: Diurnal Variationsmentioning

confidence: 80%

Diurnal, Seasonal, and Blood-Processing Patterns in Levels of Circulating Fibrinogen, Fibrin D-Dimer, C-Reactive Protein, Tissue Plasminogen Activator, and von Willebrand Factor in a 45-Year-Old Population

et al. 2007

View full text Add to dashboard Cite

Background-Circulating levels of fibrinogen, fibrin D-dimer, C-reactive protein (CRP), tissue plasminogen activator antigen (t-PA) and von Willebrand factor are associated with incident coronary heart disease. We describe cross-sectional diurnal, seasonal, and blood-processing patterns for these variables, and assess whether they represent important sources of variability that should be taken into account in epidemiological studies or for additional risk prediction in individuals. Methods and Results-A total of 9377 men and women aged 45 years were visited in their homes and blood-sampled for fibrinogen, D-dimer, CRP, t-PA, and von Willebrand factor. These variables were examined in relation to the time of blood sample collection, day of the year, and delay in processing. All variables exhibited statistically significant diurnal sinusoidality (PՅ0.02). Our models predicted a peak rise for fibrinogen and von Willebrand factor at midday, with overall diurnal variations of 3% and 10%, respectively, after adjustment for standard cardiovascular risk factors. D-dimer exhibited a peak at 14:00 hours, CRP at 15:00 hours, and t-PA at 10:00 hours with diurnal variations of 10%, 34%, and 55%, respectively, after full adjustment. All variables except CRP showed seasonal heterogeneity. Greater delays in processing blood samples were associated with higher levels of t-PA in particular. The proportion of variation attributed to the diurnal, seasonal, and processing effects was 2% for fibrinogen and von Willebrand factor; 9% for D-dimer, 1% for CRP, and 16% for t-PA. Conclusions-Temporal variations are important sources of heterogeneity that may bias the analysis of epidemiological studies and coronary heart disease risk prediction in individuals. Sample-processing delay is particularly important for t-PA.

show abstract

“…It is well known that ischemic cardiac events such as unstable angina and acute myocardial infarction occur within the first few hours after waking and becoming active. 6,7 This is because these events depend on a surge in a series of physiologic parameters, for example, heart rate, 8,9 blood pressure (BP), 8,9 platelet aggregability, 10,11 and blood concentrations of epinephrine, norepinephrine, and angiotensin II, 8,9 which are to some degree controlled by time-dependent proteins or gene expression. 12,13 Circadian variations in circulatory functions have been reported in many mammals including dogs, 8,14,15 and LAP would be expected to have some variation because the left atrium works as a volume reservoir like the right atrium, in which the pressure is known to have circadian variations.…”

mentioning

confidence: 99%

Daily Rhythms of Left Atrial Pressure in Beagle Dogs with Mitral Valve Regurgitation

Ishikawa¹,

Tanaka²,

Suzuki³

et al. 2009

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: Mitral valve regurgitation (MR) causes increased left atrial pressure (LAP) and is associated with occurrence of clinical signs. It will be useful to understand diurnal variations of LAP for the management of MR.Hypothesis: Circulatory parameters and diurnal rhythm are linked to clinical signs in cardiac diseases. LAP also exhibits a diurnal rhythm in dogs with MR.Animals: Five healthy Beagle dogs weighing 9.8-12.8 kg (3 males and 2 females; aged 2 years) were used. Methods: A radiotelemetry system for continuous measurement of LAP was used in this study. Rupture of the chordae tendineae was experimentally induced via left atriotomy, and a transmitter catheter was inserted into the left atrium. The body of the transmitter was implanted SC. After clinical condition was stabilized, the severity of MR was evaluated by echocardiography, and LAP was recorded for 72 consecutive hours for the analysis of diurnal variation.Results: Abrupt increases in LAP, which averaged 16.7 mmHg, were observed at feeding periods. In contrast, strong diurnal LAP variations were found, with a significant but slight increase in daytime LAP compared with nighttime LAP.Conclusions and Clinical Importance: Diurnal LAP is characterized by a slight but significant nocturnal decrease and abrupt increases in response to excitation. The latter seemed to be more important considering the relationship with clinical manifestations. The clinical relevance of exercise restriction in the management of MR was acknowledged.

show abstract

Circadian variation in platelet function in healthy volunteers

Cited by 81 publications

References 19 publications

Altered Circadian Rhythm of Platelet Aggregation in Hemodialyzed Patients

Altered Circadian Rhythm of Platelet Aggregation in Hemodialyzed Patients

Diurnal, Seasonal, and Blood-Processing Patterns in Levels of Circulating Fibrinogen, Fibrin D-Dimer, C-Reactive Protein, Tissue Plasminogen Activator, and von Willebrand Factor in a 45-Year-Old Population

Daily Rhythms of Left Atrial Pressure in Beagle Dogs with Mitral Valve Regurgitation

Contact Info

Product

Resources

About