Circadian Variation in Nasal Reactivity in Children with Allergic Rhinitis: Correlation with the Activity of Eosinophils and Basophilic Cells

Aoyagi, Masahiko; Watanabe, Hiroko; Sekine, Kunio; Nishimuta, Toshiyuki; Konno, Akiyoshi; Shimojo, Naoki; Kohno, Yoichi

doi:10.1159/000053604

Cited by 36 publications

(34 citation statements)

References 22 publications

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“…36,37 Allergic rhinitis-related inflammatory mediators also exhibit a circadian pattern, with levels peaking in early morning. 38 In addition, sympathetic tone decreases at night, resulting in a relative parasympathetic excess, which is associated with nasal congestion and reduced bronchial dilation. 39 Several mediators involved in the allergic response also have been implicated in the pathophysiology of sleep disruption.…”

Section: Mechanisms Of Nasal Congestion: Impact On Sleep Quality and mentioning

confidence: 99%

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Storms¹

2008

Primary Care Respiratory Journal

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Allergic rhinitis (AR) is an extremely common health problem affecting 20 to 40 million Americans and between 10-25% of the world's population. Patients with AR suffer from both nasal symptoms (congestion, rhinorrhea, itching, and sneezing) and ocular symptoms (itching, redness, and tearing). The negative impact on sleep quality and quantity, and consequently on various aspects of the patient's life, is an under-recognised and under-treated component of AR morbidity. Nasal congestion, which is one of the most bothersome and prevalent symptoms of AR, is thought to be the leading symptom responsible for rhinitis-related sleep problems.In addition to reducing clinical symptoms, pharmacologic therapies for AR that specifically reduce inflammatory cells and mediators -and therefore nasal congestion and other symptoms -should also improve sleep quality and overall quality of life (QOL). Intranasal corticosteroids (INS) are the current mainstay of therapy for AR. Results of a number of clinical trials demonstrate that INS effectively reduce nasal congestion and ocular symptoms, improve sleep quality, and decrease daytime somnolence. Intranasal corticosteroids have also proved to be effective in reducing symptoms of acute rhinosinusitis and nasal polyposis, both of which also negatively impact on sleep quality. Intranasal corticosteroids are considered safe due to their low systemic bioavailability.

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Section: Mechanisms Of Nasal Congestion: Impact On Sleep Quality and mentioning

confidence: 99%

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Storms¹

2008

Primary Care Respiratory Journal

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“…Mediators from eosinophils, particularly eosinophil cationic protein, play a pivotal role in the pathogenesis of allergic rhinitis and are under intensive investigation [51, 52, 53, 54]. The levels of inflammatory products of eosinophils and basophilic cells (ECP, histamine and tryptase) in nasal secretions showed a direct association with the circadian variation in nasal reactivity to methacholine and symptoms of allergic rhinitis [55]. Our data showed that the number of eosinophils from nasal mucosa in patients with HDM-sensitive allergic rhinitis was correlated with levels of ICAM-1 expression on nasal epithelial cells, a stuffy nose, and the number of neutrophils from nasal mucosa, whereas ICAM-1 expression on the nasal mucosal epithelial cells did not correlate with any parameters except the number of eosinophils.…”

Section: Discussionmentioning

confidence: 99%

Eosinophil Count in Nasal Mucosa Is More Suitable than the Number of ICAM-1-Positive Nasal Epithelial Cells to Evaluate the Severity of House Dust Mite-Sensitive Allergic Rhinitis: A Clinical Correlation Study

Klaewsongkram

Ruxrungtham²,

Wannakrairot³

et al. 2003

Int Arch Allergy Immunol

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Background: House dust mite (HDM)-sensitive allergic rhinitis is a perennial rhinitis with persistent nasal inflammation. Currently, there are no reliable parameters to monitor the severity of perennial allergic rhinitis. The purpose of this study was to evaluate correlations between clinical and laboratory parameters in patients with HDM-sensitive allergic rhinitis. Methods: We measured nasal symptoms, did the Dermatophagoides pteronyssinus (Der P) skin prick test (SPT), evaluated the Der P allergen nasal challenge threshold, and laboratory parameters [(1) inflammatory cell count from nasal mucosal scraping specimens: eosinophils and neutrophils and (2) immunocytochemistry: ICAM-1 expression on nasal epithelial cells] in 20 cases of HDM-sensitive allergic rhinitis and performed correlation tests between all parameters. Results: The wheal diameter induced by Der P SPT was significantly correlated with the Der P allergen nasal challenge threshold (p = 0.001). The number of eosinophils from nasal mucosal scrapping specimens was correlated with the ICAM-1 expression on nasal epithelial cells (p = 0.039), the number of neutrophils from nasal mucosal scrapping specimens (p = 0.001), and nasal stuffiness (p = 0.037) but did not correlate with total nasal symptom scores. Conclusion: Clinical symptoms of HDM-sensitive allergic rhinitis showed a poor correlation with inflammatory parameters. The eosinophil count in nasal mucosa is correlated with ICAM-1 expression and more suitable than ICAM-1 levels to evaluate the severity of HDM-sensitive allergic rhinitis. This study also supports the role of the SPT in the diagnosis of nasal allergy to HDM.

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“…This daily rhythm in hypersensitivity to allergens contributes to the daily rhythms observed in AR (Nakamura et al 2011;Nakamura et al 2016). For example in children exposed to an allergic challenge at 6 am, more nasal secretions are produced than when exposed at 3 pm (Aoyagi et al 1999). Furthermore, the commonest allergen for patients suffering from AR is house dust mite.…”

Section: Allergic Rhinitismentioning

confidence: 99%

A circadian based inflammatory response – implications for respiratory disease and treatment

Comas

Gordon

Oliver

et al. 2017

Sleep Science Practice

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Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and organs of the immune system as well as clock-controlled genes that regulate immune function. Circadian disruption leads to dysregulation of immune responses and inflammation which can further disrupt circadian rhythms. The response of organisms to immune challenges, such as allergic reactions also vary depending on time of the day, which can lead to detrimental responses particularly during the rest and early active periods. This review evaluates what is currently known in terms of circadian biology of immune response and the cross-talk between circadian and immune system. We discuss the circadian pattern of three respiratory-related inflammatory diseases, chronic obstructive pulmonary disease, allergic rhinitis and asthma. Increasing our knowledge on circadian patterns of immune responses and developing chronotherapeutic studies in inflammatory diseases with strong circadian patterns will lead to preventive measures as well as improved therapies focussing on the circadian rhythms of symptoms and the daily variation of the patients' responses to medication.

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Circadian Variation in Nasal Reactivity in Children with Allergic Rhinitis: Correlation with the Activity of Eosinophils and Basophilic Cells

Cited by 36 publications

References 22 publications

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Eosinophil Count in Nasal Mucosa Is More Suitable than the Number of ICAM-1-Positive Nasal Epithelial Cells to Evaluate the Severity of House Dust Mite-Sensitive Allergic Rhinitis: A Clinical Correlation Study

A circadian based inflammatory response – implications for respiratory disease and treatment

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