Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging

Nilsson, Carina; Ståhlberg, Freddy; Thomsen, Carsten; Henriksen, O.; Herning, Margrethe; Owman, Christer

doi:10.1152/ajpregu.1992.262.1.r20

Cited by 158 publications

(156 citation statements)

References 0 publications

Supporting

Mentioning

145

Contrasting

Unclassified

Order By: Relevance

“…In children with hydrocephalus and an intrathecal catheter, circadian rhythms are seen in intracranial pressure, achieving twice the pressure during slow-wave sleep compared to the awake state [149]. In adult volunteers (25-32 years), maximal CSF production was estimated as 42 ± 2 ml/h at 02:00 in the middle of the sleep cycle (range 35-48 ml/h n = 6), whereas the minimum was 12 ± 7 ml/h at 18:00 in the afternoon [129]. This gives a range of around 300-1000 ml CSF produced per day, depending on the time of day that the measurements are made.…”

Section: Pulsatile Flow Of Csfmentioning

confidence: 97%

“…These techniques are not without methodological issues [22], but the weight of evidence favours a second-to-second pulsatile movement of CSF through the ventricular system, which also changes throughout the day. Early MRI studies by Nilsson et al [129] observed pulsatile CSF flow through the cerebral aqueduct, and CSF velocity varied with cardiac cycle. During cardiac systole, CSF flowed approximately 8 mm/s toward the posterior brain (caudally), then gently back at 5 mm/s to the anterior brain (cranially) during cardiac diastole.…”

Section: Pulsatile Flow Of Csfmentioning

confidence: 99%

See 1 more Smart Citation

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

et al. 2018

View full text Add to dashboard Cite

Brain fluids are rigidly regulated to provide stable environments for neuronal function, e.g., low K + , Ca 2+ , and protein to optimise signalling and minimise neurotoxicity. At the same time, neuronal and astroglial waste must be promptly removed. The interstitial fluid (ISF) of the brain tissue and the cerebrospinal fluid (CSF) bathing the CNS are integral to this homeostasis and the idea of a glia-lymph or 'glymphatic' system for waste clearance from brain has developed over the last 5 years. This links bulk (convective) flow of CSF into brain along the outside of penetrating arteries, glia-mediated convective transport of fluid and solutes through the brain extracellular space (ECS) involving the aquaporin-4 (AQP4) water channel, and finally delivery of fluid to venules for clearance along peri-venous spaces. However, recent evidence favours important amendments to the 'glymphatic' hypothesis, particularly concerning the role of glia and transfer of solutes within the ECS. This review discusses studies which question the role of AQP4 in ISF flow and the lack of evidence for its ability to transport solutes; summarizes attributes of brain ECS that strongly favour the diffusion of small and large molecules without ISF flow; discusses work on hydraulic conductivity and the nature of the extracellular matrix which may impede fluid movement; and reconsiders the roles of the perivascular space (PVS) in CSF-ISF exchange and drainage. We also consider the extent to which CSF-ISF exchange is possible and desirable, the impact of neuropathology on fluid drainage, and why using CSF as a proxy measure of brain components or drug delivery is problematic. We propose that new work and key historical studies both support the concept of a perivascular fluid system, whereby CSF enters the brain via PVS convective flow or dispersion along larger caliber arteries/arterioles, diffusion predominantly regulates CSF/ISF exchange at the level of the neurovascular unit associated with CNS microvessels, and, finally, a mixture of CSF/ISF/waste products is normally cleared along the PVS of venules/veins as well as other pathways; such a system may or may not constitute a true 'circulation', but, at the least, suggests a comprehensive re-evaluation of the previously proposed 'glymphatic' concepts in favour of a new system better taking into account basic cerebrovascular physiology and fluid transport considerations.

show abstract

Section: Pulsatile Flow Of Csfmentioning

confidence: 97%

Section: Pulsatile Flow Of Csfmentioning

confidence: 99%

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

et al. 2018

View full text Add to dashboard Cite

show abstract

“…1a. All subjects underwent the MRI exam during the same time of day (in the afternoon hours) to control for circadian variation, as previously proposed (13). The cine PC sequence was acquired with the AoS in the center of the FOV, such that the wraparound artifact was present in the edges of the FOV, but did not overlap with the desired region of interest (ROI).…”

Section: Image Acquisitionmentioning

confidence: 99%

Cine cerebrospinal fluid imaging in multiple sclerosis

Magnano

Schirda

Weinstock‐Guttman

et al. 2012

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius in multiple sclerosis (MS) patients and healthy controls (HC) using cine phase contrast imaging. Materials and Methods:In all, 67 MS patients (48 relapsing-remitting [RR] and 19 secondary-progressive [SP]), nine patients with clinically isolated syndrome (CIS), and 35 age-and sex-matched HC were examined. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and magnetic resonance imaging (MRI) disease outcomes.Results: Significantly decreased CSF net flow was detected in MS patients compared to HC (À3.7 vs. À7.1 mL/beat, P ¼ 0.005). There was a trend for increased net positive flow between SP, RR, and CIS patients. Altered CSF flow and velocity measures were associated with more severe T1 and T2 lesion volumes, lateral and fourth ventricular volumes, and third ventricular width in MS and CIS patients (P < 0.01 for all). In CIS patients, conversion to clinically definite MS in the following year was related to decreased CSF net flow (P ¼ 0.007). There was a trend between increased annual relapse rate and altered CSF flow/velocity measures in RRMS patients (P < 0.05).Conclusion: CSF flow dynamics are altered in MS patients. More severe clinical and MRI outcomes in RRMS and CIS patients relate to altered CSF flow and velocity measures.

show abstract

“…Nilsson et al [31] found that a cranial direction could be considered as a CSF flow displacement toward its main resorption sites at the cranial level.…”

Section: K-mean Methodsmentioning

confidence: 99%

“…The circadian cycle and subject's age also influence the CSF production rate; Nilsson et al [31] found, for healthy volunteers, a variation of 30 ml/h between the minimum and maximum production period at 18:00 pm and 2:00 am respectively. May et al [27] found in elderly healthy individuals a significantly lower CSF production compared with healthy young subjects.…”

Section: Figure 25 Choroid Plexus and Arachnoid Granulations Adaptementioning

confidence: 99%

Intracranial fluids dynamics: a quantitative evaluation by means of phase-contrast magnetic resonance imaging

Ordoñez¹,

Natalia²

View full text Add to dashboard Cite

A mis padres Cecilia y Justo Pastor, por todos los principios éticos y morales impartidos;que prevalecerán durante toda mi vida. Al mayor regalo que Dios trajo a mi familia, María del Pilar. Gracias por enseñarme a valorar el sentido de la vida.A Elvis por toda la paciencia, amor y comprensión que día a día me fortalecieron. AcknowledgmentsDuring the development of this thesis, I have met many people and I learnt from all of them. Besides this, many people helped indirectly to the realization of this thesis helping me to feel at home in this foreign country. I hope I can express my gratitude to all of them and apologize in case I forget somebody. Dr. Luís Martí-Bonmatí, first of all I would like to thank him for offering me the opportunity to do research with him. Over time I have collected lots of "paper tablecloths" of the Italian restaurant, where we discussed step by step the different points that allowed the development of this thesis. I feel great admiration because he is able to transmit and share his knowledge in a polite way and I am especially thankful that he shared it with me during all these years. These techniques also must take into account the errors associated with the partial volume effect (PVE), caused by the presence of stationary tissue and flow inside the voxels of the periphery of the region under study.The overall objective of this thesis was to develop a reproducible methodology to quantitatively evaluate the intracranial fluids dynamics within CSF spaces (aqueduct of Sylvius, prepontine cistern and subarachnoid space C2C3) and main cerebral blood vessels (carotids and vertebral arteries, jugular veins, straight and sagittal superior sinus) by means of PC-MRI. This methodology includes semiautomatic segmentation techniques by thresholding and K-means clustering that allow to delineate the ROI with great independency of the observer and to apply background and aliasing correction.Amplitude parameters (increase of flow volume in systole, mean flows, pulsatility, compliance indexes and supratentorial CSF) and temporal parameters (delay respect to the inflow blood to the brain) were quantified. The distribution of the pulsatibility of the CSF flow between the ventricular and subarachnoid spaces was measured as the ratio of aqueductal to C2C3 cervical stroke volume.The commitment between the acquisition protocol and the used methodology to calculate each one of the parameters has helped to establish reliable and reproducible normality ranges for each one of them. The evaluated control subjects were asymptomatic and they had no history of intracranial hypertension, neurological disease, vascular events or relevant risks factors allowing to generalize the measures. They were studied at the same hourly stripe to avoid influences of the circadian cycle. All acquisitions were carried with a 3.0T MR unit to avoid the influence of the field strength on parameters.In conclusion an adequate methodology was developed to carry out quick ResumenEl volumen intracraneal lo integran el volumen de líquido ...

show abstract

Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging

Cited by 158 publications

References 0 publications

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

Cine cerebrospinal fluid imaging in multiple sclerosis

Intracranial fluids dynamics: a quantitative evaluation by means of phase-contrast magnetic resonance imaging

Contact Info

Product

Resources

About