Circadian temporal organization of lipidic fractions in elderly people. Entrainment to the dietary schedule

Trotti, R.; Rondanelli, Mariangela; Cuzzoni, Giovanni; Ferrari, Ettore; d’Eril, Gianvico Melzi

doi:10.1007/bf03324422

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…Por outro lado, após os 50 anos de idade, estas alterações foram observadas apenas no grupo controle. Tal fato pode refletir indícios de alteração no metabolismo lipídico nestes indivíduos, uma amostra representativa da população em geral nem sempre esclarecida sobre a real composição de uma alimentação saudável 23 , ou desorganizações temporais circadianas, provenientes do envelhecimento do sistema nervoso central 24 . Ainda, pode sugerir normalização desses parâ-metros nos pacientes ora estudados sob intervenção médica, seja com mudança do estilo de vida ou com uso de hipolipemiantes.…”

Section: Discussionunclassified

Prevalência de síndrome metabólica em indivíduos brasileiros pelos critérios de NCEP-ATPIII e IDF

Nakazone¹,

Pinheiro²,

Braile³

et al. 2007

Rev. Assoc. Med. Bras.

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Section: Discussionunclassified

Prevalência de síndrome metabólica em indivíduos brasileiros pelos critérios de NCEP-ATPIII e IDF

Nakazone¹,

Pinheiro²,

Braile³

et al. 2007

Rev. Assoc. Med. Bras.

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“…The daily changes in LDL/HDL/VLDL are related to interactions among these lipoproteins (enzymatic and nonenzymatic) with the loose of surface components from VLDL (to HDL) and with transfer of HDL-LDL associated lipids [29]. The feeding schedule is a powerful synchronizer of the daily lipidic profile [30]. Diurnal triglyceride or LDL profiels may be used to estimate the total daily load of potential atherogenic particles to which individuals are subjected during the day without the need for metabolic studies [31].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Pomegranate Extract (POMx), Simvastatin, or Metformin Therapies in Hypercholesterolemic or in Diabetic Patients on Daily Rhythms of Serum Lipids and of Oxidative Stress: A Pilot Study

Hayek¹,

Volkova²,

Attias³

et al. 2014

Horticulture

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Background: There are no data regarding the effects of conventional therapies or of dietary antioxidants in hypercholesterolemic or diabetic patients, on their lipid and oxidative stress-related daily rhythms. Objective: To investigate the effects of Pomegranate Extract (POMx), simvastatin or metformin in hypercholesterolemic or diabetic patients on daily rhythms of serum lipids and oxidative stress, and their effects on macrophage atherogenicity. Methods: Three healthy subjects, three hypercholesterolemic or two diabetic patients, participated in the current pilot study. Blood samples were collected around the clock from the same patient (every 4 h during a 24 h cycle), before and after two weeks treatment with POMx (1 pill/day), with simvastatin (20 mg/day), or with metformin (850 mgx2/day). Results: In healthy subjects, but not in hypercholesterolemic patients, HDL-cholesterol levels showed daily changes with a maximal level in the afternoon. In both groups, serum Paraoxonase 1 (PON1) arylesterase activity increased during the day between 08:00 to noon, followed by a decrement between 16:00 to 04:00. In patients treated with POMx or simvastatin, serum oxidative stress decreased at each time point vs. results obtained before therapy. In contrast to the reduction in PON1 activity from noon to evening that was observed in serum before therapy, after simvastatin therapy, there was no such a reduction. In diabetics, serum LDL-cholesterol levels showed daily changes, which were completely abolished after POMx or after metformin treatment. Diabetic serum samples before therapy increased macrophage cholesterol accumulation and oxidative stress, and this atherogenic pattern was beneficially changed after metformin therapy. Serum cortisol levels showed similar daily patterns in healthy subjects and in diabetic patients (maximum level at 08:00) whereas in hypercholesterolemic patients the highest cortisol levels were noted at 04:00. The various treatments resulted in a daily rhythm similar to that of the healthy subjects. Conclusion: In the present study we have shown, for the first time, that nutritional antioxidant such as Pomegranate Extract (POMx), as well as simvastatin or metformin therapies in hypercholesterolemic or in diabetic patients, respectively, significantly affect their daily rhythms of serum lipids and of serum oxidative stress, as well as their serum-mediated effects on macrophage atherogenicity. These results could contribute to our understanding of how to use the appropriate therapy along the appropriate time of the day for hypercholesterolemic or diabetic patients' therapy.

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“…87 If this is the case, cholesterol levels, which rise in the morning, 88 would appear higher on remeasurement at the same time in the morning, masking the possible beneficial effect of melatonin. A posture-confounding effect (mechanism described above) on serum lipid concentrations upon morning venipuncture should also be considered.…”

Section: Effect Of Melatonin On Lipidsmentioning

confidence: 99%

Melatonin and its use in atherosclerosis and dyslipidemia

Danilenko¹,

Ragino²

2013

CPT

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A review of pineal melatonin synthesis, regulation, and physiological effects indicates that not only does melatonin act as a hormonal signal of darkness, but also that it possesses antioxidant and anti-inflammatory properties. Although oxidation and inflammation play a pivotal role in atherogenesis, no studies have investigated administration of melatonin for human arterial atherosclerosis. However, 13 clinical trials have investigated use of melatonin in dyslipidemia, which is a close correlate of atherosclerosis. The results of these clinical trials, particularly the five that are placebo-controlled, are inconclusive as to whether melatonin can normalize the blood lipid profile. Significant confounders in these studies might be a phase shift of the cholesterol rhythm by melatonin, a posture effect at venipuncture, uncontrolled diet during the course of melatonin intake, and the phenomenon of regression to the mean. Thus, future studies are required, which should also consider use of higher doses of melatonin and/or measurement of oxidized forms of cholesterol-containing particles (which are the most aggressive in relation to atherogenesis) in addition to lipidic fractions.

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Circadian temporal organization of lipidic fractions in elderly people. Entrainment to the dietary schedule

Abstract: These data suggest that the circadian temporal organization of lipidic fractions is maintained in physiological aging and underline the importance of the feeding schedule as a powerful synchronizer of the daily lipidic profile.

Cited by 8 publications

References 34 publications

Prevalência de síndrome metabólica em indivíduos brasileiros pelos critérios de NCEP-ATPIII e IDF

Prevalência de síndrome metabólica em indivíduos brasileiros pelos critérios de NCEP-ATPIII e IDF

The Effects of Pomegranate Extract (POMx), Simvastatin, or Metformin Therapies in Hypercholesterolemic or in Diabetic Patients on Daily Rhythms of Serum Lipids and of Oxidative Stress: A Pilot Study

Melatonin and its use in atherosclerosis and dyslipidemia

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