Circadian rhythms of In Vitro incorporation of 3H-melatonin into organs of the hypothalamic-pituitary-thyroid system in rats

Bondarenko, L. A.; Gevorkyan, A. R.

doi:10.1007/s10517-007-0231-7

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…We recorded an analogous but more clearly pronounced pattern of circadian rhythms of binding of 3 Н-melatonin in the hypophysis where the maximum of this process was observed during daytime, while its minimum was observed at night [66]. At the same time, the intensity of binding of 3 Н-melatonin in the hypothalamus at night showed an opposite trend.…”

Section: The Brain Epiphysis and Hhta: Circadian And Seasonal (Circanmentioning

confidence: 64%

“…We found that the hypothalamus, hypophysis, and thyroid gland are capable of binding 3 Н-melatonin both during day and night; however, the intensity of its incorporation into the hypophysis and thyroid gland is high in the daytime and low at night. At the same time, the uptake of 3 Н-label by the hypothalamus trends toward an increase at night [66].…”

Section: The Brain Epiphysis and Hhta: Circadian And Seasonal (Circanmentioning

confidence: 87%

“…At the same time, the intensity of binding of 3 Н-melatonin in the hypothalamus at night showed an opposite trend. Therefore, there are reasons to believe that the overall number of free melatonin receptors in this organ at night even demonstrates some increase [66]. As is known, the hypothalamus is a very complex neuroendocrine structure that includes numerous subdivisions usually qualified as nuclei; these nuclei are responsible for the control of many endocrine (and not only just endocrine!)…”

Section: The Brain Epiphysis and Hhta: Circadian And Seasonal (Circanmentioning

confidence: 99%

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Role of Melatonin in the Mechanisms Underlying Neuroendocrine Control of the Hypothalamo-Hypophyseal-Thyroid Axis

2008

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The authors of this review generalize and analyze the published data, as well as their own findings, related to melatonin-mediated interaction of the pineal gland (the brain epiphysis) with the hypothalamo-hypophysealthyroid axis (HHTA). The review deals with (i) historical aspect of development of the concepts on neuroendocrine mechanisms underlying the control of functions of the thyroid gland, (ii) data on circadian and seasonal rhythms of the functioning of the epiphysis and HHTA, (iii) basic facts about direct and feedback connections between the brain epiphysis and HHTA, and (iv) overview of the experimental data on age-related changes in the epiphysis-thyroid axis.

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Section: The Brain Epiphysis and Hhta: Circadian And Seasonal (Circanmentioning

confidence: 64%

Section: The Brain Epiphysis and Hhta: Circadian And Seasonal (Circanmentioning

confidence: 87%

Section: The Brain Epiphysis and Hhta: Circadian And Seasonal (Circanmentioning

confidence: 99%

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Role of Melatonin in the Mechanisms Underlying Neuroendocrine Control of the Hypothalamo-Hypophyseal-Thyroid Axis

2008

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Infradian Rhythm of the Content of Secretory Granules in Pinealocyte Cytoplasm in Mice and Rats

et al. 2018

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The numerical density of secretory granules dense-core vesicles (DCV) in the cytoplasm of pinealocytes of the pineal gland was estimated by transmission electron microscopy in male white mice and Wistar rats. The 3-day biorhythm and lunaphase changes in the DCV content in the perikaryon and the processes of pinealocytes, which are manifested significantly in different seasons of the year, are established. The three-day biorhythm in adult male mice in comparison with younger male rats is not expressed uniformly in different phases of the moon. The in-phase manifestation of infradian biorhythms in different species of animals during the year with an unchanged daily photophase indicates the existence of common external synchronizers for mammals of these biorhythms that are not associated with the light/dark cycle.

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Dynamics of Changes in the Indicators of Mathematical Analysis of Heart Rate in Conditions of Adrenaline Myocardial Dystrophy against the Background of Different Functional Activity of the Pineal Gland

Chebotar¹,

Larycheva²,

Niepieina³

et al. 2021

Ukr. ž. med. bìol. sportu

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The purpose of the study was to examine the features of heart rate variability in experimental hyper- and hypofunction of the pineal gland, complicated by adrenal myocardial dystrophy. Materials and methods. To solve the set tasks, three models of functional states were created: hypo-, hyperfunction of the pineal gland, adrenaline myocardial dystrophy. Hypermelatoninemia was reproduced by administering melatonin. The hypofunction of the pineal gland was simulated by round-the-clock lighting. An experimental model of cardiac pathology, namely adrenaline myocardial dystrophy, was reproduced by administering adrenaline hydrochloride. The degree of tension of regulatory mechanisms and mechanisms of nervous regulation was assessed by mathematical analysis of heart rate variability. Results and discussion. The task of mathematical analysis is to extract “hidden information” and thereby assess the state and degree of tension of the regulatory mechanisms of the whole organism. According to the authors, mathematical analysis allows a differentiated approach to the assessment of regulatory effects, which is done by the nervous autonomic system, subcortical structures and the cerebral cortex. The data obtained by the authors suggest that the introduction of adrenaline in conditions of hypofunction of the pineal gland have cause-and-effect changes. These changes lead to disorders of autonomic regulation and possibly a trigger mechanism for a decrease in melatonin production by the pineal gland. Studies have shown that one of the advantages in conditions of hyperfunction of the pineal gland is the dominant role of parasympathetic processes in the mechanisms of adaptation of the heart to conditions of adrenal myocardial dystrophy. Timely and sufficient activation of melatonin provides a high efficiency of compensatory-adaptive changes and a positive role in increasing myocardial resistance. Conclusion. The results of the study showed that the dynamics of changes in the values of the indicators of the mathematical analysis of the heart rate in adrenal myocardial dystrophy against the background of hypo- and hyperfunction of the pineal gland revealed unidirectional changes. These changes are manifested in a decrease in heart rate, stress index and vegetative balance indicator. Consequently, the results obtained suggest that the introduction of melatonin against the background of adrenal myocardial dystrophy has a general corrective effect on the restoration of the functional state of the heart. Based on the results, the authors consider it appropriate to continue the study of the influence of various stressors on the functional state of the heart in conditions of different physiological activity of the pineal gland

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Circadian rhythms of In Vitro incorporation of 3H-melatonin into organs of the hypothalamic-pituitary-thyroid system in rats

Cited by 3 publications

References 7 publications

Role of Melatonin in the Mechanisms Underlying Neuroendocrine Control of the Hypothalamo-Hypophyseal-Thyroid Axis

Role of Melatonin in the Mechanisms Underlying Neuroendocrine Control of the Hypothalamo-Hypophyseal-Thyroid Axis

Infradian Rhythm of the Content of Secretory Granules in Pinealocyte Cytoplasm in Mice and Rats

Dynamics of Changes in the Indicators of Mathematical Analysis of Heart Rate in Conditions of Adrenaline Myocardial Dystrophy against the Background of Different Functional Activity of the Pineal Gland

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