Circadian Rhythms in the Fetus and Newborn: Significance of Interactions with Maternal Physiology and the Environment

Serón-Ferré, Marı́a; Richter, Hans G.; Valenzuela, Guillermo J.; Torres-Farfán, Claudia

doi:10.1007/978-1-4939-3014-2_7

Cited by 12 publications

(15 citation statements)

References 86 publications

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“…Although cortisol and DHAS circadian production is controlled by several mechanisms, it is strongly regulated by the photoperiod in adult nonhuman primates [ 8 , 30 , 40 ], pointing to a direct involvement of the primate adrenal clock. Our previous results in the primate fetus demonstrated the presence of a circadian rhythm of DHAS, with an acrophase opposite to the one reported in juvenile and adult humans [ 41 ] and in rhesus monkeys [ 40 ], but with similar clock time differences than those found in 10-month-old control infants reported here, in which the maximal levels of DHAS were found at 2000 h. The differences between infant capuchin and those reported in adult rhesus may reflect developmental changes in DHAS circadian rhythm, as reported in humans and sheep for cortisol rhythm or in rats for corticosterone rhythm (cited by [ 42 ]). Therefore, an effect of the maternal chronodisruption over the molecular mechanism controlling the adrenal circadian clock must be considered.…”

Section: Discussionsupporting

confidence: 82%

Developmental Programming of Capuchin Monkey Adrenal Dysfunction by Gestational Chronodisruption

Richter

Méndez

Abarzúa-Catalán

et al. 2018

BioMed Research International

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In the capuchin monkey (Cebus apella), a new-world nonhuman primate, maternal exposure to constant light during last third of gestation induces precocious maturation of the fetal adrenal and increased plasma cortisol in the newborn. Here, we further explored the effects of this challenge on the developmental programming of adrenal function in newborn and infant capuchin monkeys. We measured (i) plasma dehydroepiandrosterone sulphate (DHAS) and cortisol response to ACTH in infants with suppressed endogenous ACTH, (ii) plasma DHAS and cortisol response to ACTH in vitro, and (iii) adrenal weight and expression level of key factors in steroid synthesis (StAR and 3β-HSD). In one-month-old infants from mothers subjected to constant light, plasma levels of cortisol and cortisol response to ACTH were twofold higher, whereas plasma levels of DHAS and DHAS response to ACTH were markedly reduced, compared to control conditions. At 10 months of age, DHAS levels were still lower but closer to control animals, whereas cortisol response to ACTH was similar in both experimental groups. A compensatory response was detected at the adrenal level, consisting of a 30% increase in adrenal weight and about 50% reduction of both StAR and 3β-HSD mRNA and protein expression and the magnitude of DHAS and cortisol response to ACTH in vitro. Hence, at birth and at 10 months of age, there were differential effects in DHAS, cortisol production, and their response to ACTH. However, by 10 months of age, these subsided, leading to a normal cortisol response to ACTH. These compensatory mechanisms may help to overcome the adrenal alterations induced during pregnancy to restore normal cortisol concentrations in the growing infant.

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Section: Discussionsupporting

confidence: 82%

Developmental Programming of Capuchin Monkey Adrenal Dysfunction by Gestational Chronodisruption

Richter

Méndez

Abarzúa-Catalán

et al. 2018

BioMed Research International

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“…Mother‐infant synchrony originates from the mother's recognition of the infant's first biological rhythms in utero , such as heart rhythms and sleep‐wake cycles, which send signals to the placenta and the maternal brain 184‐186 . Following birth, mothers entrain these familiar rhythms into the dyadic exchange.…”

Section: Synchrony From Infancy To Adulthood: the Unfolding Of Resilimentioning

confidence: 99%

What is resilience: an affiliative neuroscience approach

2020

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Resilience – a key topic in clinical science and practice – still lacks a clear conceptualization that integrates its evolutionary and human‐specific features, refrains from exclusive focus on fear physiology, incorporates a developmental approach, and, most importantly, is not based on the negation (i.e., absence of symptoms following trauma). Building on the initial condition of mammals, whose brain matures in the context of the mother's body and caregiving behavior, we argue that systems and processes that participate in tuning the brain to the social ecology and adapting to its hardships mark the construct of resilience. These include the oxytocin system, the affiliative brain, and biobehavioral synchrony, all characterized by great flexibility across phylogenesis and ontogenesis. Three core features of resilience are outlined: plasticity, sociality and meaning. Mechanisms of sociality by which coordinated action supports diversity, endurance and adaptation are described across animal evolution. Humans' biobehavioral synchrony matures from maternal attuned behavior in the postpartum to adult‐adult relationships of empathy, perspective‐taking and intimacy, and extends from the mother‐child relationship to other affiliative bonds throughout life, charting a fundamental trajectory in the development of resilience. Findings from three high‐risk cohorts, each tapping a distinct disruption to maternal‐infant bonding (prematurity, maternal depression, and early life stress/trauma), and followed from birth to adolescence/young adulthood, demonstrate how components of the neurobiology of affiliation confer resilience and uniquely shape the social brain.

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“…A recent review concluded that, as early as during fetal development, disruption of circadian rhythms in the mother may adversely affect fetal development and growth (87). One feature of circadian misalignment is the altered timing of nutrient supply to the fetus, which may potentially play a role that is yet to be fully elucidated (87).…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health

Almoosawi

Vingeliene

Gachon

et al. 2019

Advances in Nutrition

154

121

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Chrono-nutrition is an emerging research field in nutritional epidemiology that encompasses 3 dimensions of eating behavior: timing, frequency, and regularity. To date, few studies have investigated how an individual's circadian typology, i.e., one's chronotype, affects the association between chrono-nutrition and cardiometabolic health. This review sets the directions for future research by providing a narrative overview of recent epidemiologic research on chronotype, its determinants, and its association with dietary intake and cardiometabolic health. Limited research was found on the association between chronotype and dietary intake in infants, children, and older adults. Moreover, most of the evidence in adolescents and adults was restricted to cross-sectional surveys with few longitudinal cohorts simultaneously collecting data on chronotype and dietary intake. There was a gap in the research concerning the association between chronotype and the 3 dimensions of chrono-nutrition. Whether chronotype modifies the association between diet and cardiometabolic health outcomes remains to be elucidated. In conclusion, further research is required to understand the interplay between chronotype, chrono-nutrition, and cardiometabolic health outcomes.

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Circadian Rhythms in the Fetus and Newborn: Significance of Interactions with Maternal Physiology and the Environment

Cited by 12 publications

References 86 publications

Developmental Programming of Capuchin Monkey Adrenal Dysfunction by Gestational Chronodisruption

Developmental Programming of Capuchin Monkey Adrenal Dysfunction by Gestational Chronodisruption

What is resilience: an affiliative neuroscience approach

Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health

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