Circadian rhythms in disaccharidases of rat small intestine and its relation to food intake

Saito, Masayuki; Murakami, Eiki; Suda, Masami

doi:10.1016/0304-4165(76)90181-1

Cited by 88 publications

(41 citation statements)

References 6 publications

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“…The activities of the digestive enzymes of maltase and sucrase show circadian variations, being high at night and low in the daytime in rats fed a Zn-adequate diet ad libitum (38). Saito et al (38)(39)(40) proposed that the disaccharidase rhythms are not a direct consequence of food intake, but that anticipation of food intake acts as a trigger for initiation of the disaccharidase rhythm. In the previous paper (31) we found that food-intake of the maltose diet or the sucrose diet in rats fed a Zn-deficient diet shows a cyclic variation not seen in rats fed a Zn-adequate diet.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Maltose Preference by Selection from Dextrin, Maltose and Glucose Diets in Zinc-Deficient Rats

Horikawa

Uehara

Matsuda

et al. 2008

J Nutr Sci Vitaminol

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Summary This study examined whether the chain length of glucose in the diet could affect the selection of foods by Zn-adequate and Zn-deficient rats. Dextrin, maltose and glucose were used as sources of carbohydrate in the diet and the selection patterns of the rats were analyzed for 28 d by a 3-choice selection. Diets provided as a set of three either Zn-adequate or Zn-deficient diets were rotated daily. The Zn-adequate control rats selected widely from the three diets throughout the 28 d. In contrast, rats fed a Zn-deficient diet selected exclusively and continuously the dextrin diet or dextrin and glucose diets from the three diets over the experimental periods. The average daily total food intakes of rats fed a Zn-deficient diet were very significantly decreased. The selections of dextrin, maltose and glucose diets in the 3-choice methods of the control rats were 5.7 Ϯ 1.6 b , 5.8 Ϯ 2.0 b and 2.7 Ϯ 0.9 a g/ d, respectively ( p Ͻ 0.05), and those of the Zn-deficient rats were 6.4 Ϯ 2.5 c , 0.8 Ϯ 1.3 a and 2.6 Ϯ 1.4 b g/d, respectively ( p Ͻ 0.05). The ratios of the selected maltose-diet in the Zn-adequate control and the Zn-deficient rats were 40.8 Ϯ 13.8 and 9.0 Ϯ 15.6%, respectively ( p Ͻ 0.01) and those of the dextrin-diet were 40.3 Ϯ 11.4 and 63.0 Ϯ 22.3%, respectively ( p Ͻ 0.05). The decreased preference for the maltose-diet in the Zn-deficient rats may reflect the increased selection of the dextrin-diet.

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Section: Discussionmentioning

confidence: 99%

Modulation of Maltose Preference by Selection from Dextrin, Maltose and Glucose Diets in Zinc-Deficient Rats

Horikawa

Uehara

Matsuda

et al. 2008

J Nutr Sci Vitaminol

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“…Many physiological activities normally dictated by the SCN, such as body temperature, locomotor activity, and heart rate, are altered by RF [126][127][128][129]. 2-4 h before the meal, the animals display food anticipatory behavior, which is demonstrated by an increase in locomotor activity, body temperature, corticosterone secretion, gastrointestinal motility, and activity of digestive enzymes [122,125,130,131], all are known output systems of the biological clock. RF is dominant over the SCN and is effective in all lighting conditions including in SCN-lesioned animals [122,127,129,[132][133][134].…”

Section: Effect Of Restricted Feeding (Rf) On Circadian Rhythmsmentioning

confidence: 99%

Circadian Signatures in Rat Liver: From Gene Expression to Pathways

Olds¹

2014

Sleep, Circadian Rhythms, and Metabolism

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Obesity has become a serious public health problem and a major risk factor for the development of illnesses, such as insulin resistance and hypertension. Attempts to understand the causes of obesity and develop new therapeutic strategies have mostly focused on caloric intake and energy expenditure. Recent studies have shown that the circadian clock controls energy homeostasis by regulating the circadian expression and/or activity of enzymes, hormones, and transport systems involved in metabolism. Moreover, disruption of circadian rhythms leads to obesity and metabolic disorders. Therefore, it is plausible that resetting of the circadian clock can be used as a new approach to attenuate obesity. Feeding regimens, such as restricted feeding (RF), calorie restriction (CR), and intermittent fasting (IF), provide a time cue and reset the circadian clock and lead to better health. In contrast, high-fat (HF) diet leads to disrupted circadian expression of metabolic factors and obesity. This paper focuses on circadian rhythms and their link to obesity.

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“…That the circadian rhythm of sucrase activity in rats is synchronized by the time of feeding, but not by the lighting rhythm, has also been clearly established (2)(3)(4)(5). A significant rise in enzyme activity usually occurs 1 h before onset of feeding with continued elevated levels throughout the feeding period.…”

Section: Introductionmentioning

confidence: 96%

“…A number of studies have demonstrated a circadian rhythm in the activities of intestinal disaccharidases (1)(2)(3)(4)(5). That the circadian rhythm of sucrase activity in rats is synchronized by the time of feeding, but not by the lighting rhythm, has also been clearly established (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…Activity begins to decrease within 1-3 h after feeding ceases. This rhythm can be temporally shifted by altering the time of controlled feeding (5), but can be eliminated only by several days of starvation (2). Because most investigators have found a rise in enzyme activity 1 h before the scheduled beginning of feeding, many have postulated that it is the anticipation of feeding that triggers the rise in enzyme activity rather than food intake itself.…”

Section: Introductionmentioning

confidence: 99%

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Circadian Rhythm of Intestinal Sucrase Activity in Rats

Kaufman¹,

Korsmo²,

Olsen³

1980

J. Clin. Invest.

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A B S T R A C T Past investigation has revealed that the circadian rhythm of intestinal sucrase activity in rats is primarily cued by the time of feeding. We examined the mechanism of the circadian rhythm by methods involving quantitative immunoprecipitation of sucraseisomaltase protein and study of decay of radioactively labeled protein. Rats were placed on a controlled feeding regimen (1000-1500 h) and then sacrificed at 3-h intervals over a 24-h period. Immunotitration experiments indicated that the circadian rhythm was the result ofchanges in the absolute amount of sucrase-isomaltase protein present and not of changes in the enzyme's catalytic efficiency.To study the mechanism of this circadian variation in sucrase-isomaltase mass, [14C]sodium carbonate was injected and, after maximum incorporation into brush border protein, the rats were sacrified at 3-h intervals. Sucrase-isomaltase protein was isolated by immunoprecipitation, and the decrease in total disintegrations per minute over time was used to study degradation of the protein. Enzyme degradation was not constant but exhibited a clear circadian rhythm. The period of increasing enzyme mass was characterized by virtual cessation of enzyme degradation (t1/2 of 38 h), and the period of declining enzyme mass by rapid degradation (t1/2 of 6 h or less). We found similar changes in enzyme degradation in fasted animals, demonstrating that the changes were not the result of decreased isotope reutilization during feeding. We found no evidence of a circadian rhythm in [14C]leucine incorporation into the protein, suggesting that enzyme synthesis was constant.These results indicate that the circadian rhythm of sucrase activity represents changes in the total amount ofenzyme protein that are, at least in large part, secondary to changes in the enzyme's degradation rate.

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Circadian rhythms in disaccharidases of rat small intestine and its relation to food intake

Cited by 88 publications

References 6 publications

Modulation of Maltose Preference by Selection from Dextrin, Maltose and Glucose Diets in Zinc-Deficient Rats

Modulation of Maltose Preference by Selection from Dextrin, Maltose and Glucose Diets in Zinc-Deficient Rats

Circadian Signatures in Rat Liver: From Gene Expression to Pathways

Circadian Rhythm of Intestinal Sucrase Activity in Rats

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