Circadian rhythms and the <scp>HPA</scp> axis: A systems view

Androulakis, Ioannis P.

doi:10.1002/wsbm.1518

Cited by 21 publications

(17 citation statements)

References 207 publications

(262 reference statements)

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“…Considering the effect of artificial light on circadian physiology is critical in evaluating the efficacy of different lighting technologies to minimize disturbance to wildlife. Melatonin is a circadian hormone responsible for communicating photoperiod information to the body, leading to adaptive changes in endocrinology, physiology and anatomy [ 1 , 11 ]. Disruptions to the natural rhythm of melatonin, including from artificial light, can disrupt an animal's ability to adapt to environmental conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The oscillation of natural light-dark cycles provides crucial photoperiod information required to synchronize an animal's circadian clock with its external environment [ 1 ]. Circadian rhythms are entrained by short-wavelength light and play a critical role in regulating behaviour and physiology in wildlife [ 1 , 2 ]. The introduction of artificial light has profoundly altered the night-time environment and masks photoperiod changes [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Short-wavelength blue light (459–480 nm) activates the photoreceptors responsible for entraining melatonin rhythms in humans [ 7 , 8 ] and animals [ 6 , 9 ]. Light in this spectral range suppresses melatonin; therefore, peak production occurs during the dark phase [ 1 , 10 , 11 ]. The duration of the melatonin peak provides a crucial signal for encoding season [ 10 , 12 ] and modulates reproduction, immune function, metabolism and thermoregulation in animals [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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A light-exploiting insectivorous bat shows no melatonin disruption under lights with different spectra

et al. 2023

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Natural light-dark cycles synchronize an animal's internal clock with environmental conditions. The introduction of artificial light into the night-time environment masks natural light cues and has the potential to disrupt this well-established biological rhythm. Nocturnal animal species, such as bats, are adapted to low light conditions and are therefore among the most vulnerable to the impacts of artificial light at night (ALAN). The behaviour and activity of insectivorous bats is disrupted by short-wavelength artificial light at night, while long-wavelength light is less disruptive. However, the physiological consequences of this lighting have not been investigated. Here, we examine the effect of LEDs with different spectra on urinary melatonin in an insectivorous bat. We collected voluntarily voided urine samples from Gould's wattled bats ( Chalinolobus gouldii ) and measured melatonin–sulfate under ambient night-time conditions (baseline) and under red ( λ P 630 nm), amber ( λ P 601 nm), filtered warm white ( λ P 586 nm) and cool white ( λ P 457 nm) LEDs. We found no effect of light treatment on melatonin–sulfate irrespective of spectra. Our findings suggest that short-term exposure to LEDs at night do not disrupt circadian physiology in the light-exploiting Gould's wattled bat.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A light-exploiting insectivorous bat shows no melatonin disruption under lights with different spectra

et al. 2023

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“…In doing so, the circadian clock system and possible circadian-clock-regulated epilepsy processes such as the hypothalamus–pituitary–adrenal (HPA) axis and the hypothalamus–pituitary–gonadal (HPG) axis should be investigated. The circadian clock regulates the HPA axis [ 273 , 274 ] and the HPG axis [ 275 , 276 ], which are known to contribute to epilepsy pathogenesis [ 277 , 278 , 279 ]. In some epilepsies, it would be worthwhile to investigate how the circadian clock acts through the HPA axis or the HPG axis to regulate epilepsy pathogenesis.…”

Section: A Chronomodulated Strategy For Epilepsy Therapymentioning

confidence: 99%

Clocking Epilepsies: A Chronomodulated Strategy-Based Therapy for Rhythmic Seizures

Sun

Wang

2023

IJMS

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Epilepsy is a neurological disorder characterized by hypersynchronous recurrent neuronal activities and seizures, as well as loss of muscular control and sometimes awareness. Clinically, seizures have been reported to display daily variations. Conversely, circadian misalignment and circadian clock gene variants contribute to epileptic pathogenesis. Elucidation of the genetic bases of epilepsy is of great importance because the genetic variability of the patients affects the efficacies of antiepileptic drugs (AEDs). For this narrative review, we compiled 661 epilepsy-related genes from the PHGKB and OMIM databases and classified them into 3 groups: driver genes, passenger genes, and undetermined genes. We discuss the potential roles of some epilepsy driver genes based on GO and KEGG analyses, the circadian rhythmicity of human and animal epilepsies, and the mutual effects between epilepsy and sleep. We review the advantages and challenges of rodents and zebrafish as animal models for epileptic studies. Finally, we posit chronomodulated strategy-based chronotherapy for rhythmic epilepsies, integrating several lines of investigation for unraveling circadian mechanisms underpinning epileptogenesis, chronopharmacokinetic and chronopharmacodynamic examinations of AEDs, as well as mathematical/computational modeling to help develop time-of-day-specific AED dosing schedules for rhythmic epilepsy patients.

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“…Circadian rhythm is an important factor in maintaining the normal production and development of natural organisms (Androulakis, 2021).…”

Section: The Relationship Between Gut Microbiota and Circadian Rhythmsmentioning

confidence: 99%

New hints for improving sleep: Tea polyphenols mediate gut microbiota to regulate circadian disturbances

Xiang

Liu

et al. 2023

Food Frontiers

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Biological rhythm is a natural physiological phenomenon of the human body, which is regulated by the biological rhythm system, including the sleep cycle, body temperature fluctuation, endocrine level, biological metabolism, and so on. Sleep disturbance is one of the main manifestations of circadian biological rhythm disorder, which has a serious impact on people's work and quality of life. Studies have shown that gut microbiota and circadian rhythms can interact through the brain-gut pathway. Tea polyphenols can effectively modulate the composition of the intestinal microbiota. The interaction between circadian rhythm and the gut microbiota suggests that intervention with tea polyphenols is a possible way for improving sleep. Therefore, through investigating the circadian regulation mechanism of tea polyphenols mediated by gut microbiota, we can shed new light on the relationship between sleep and metabolic disturbances, as well as the beneficial effect of tea polyphenols on sleep improving.

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Circadian rhythms and the HPA axis: A systems view

Cited by 21 publications

References 207 publications

A light-exploiting insectivorous bat shows no melatonin disruption under lights with different spectra

A light-exploiting insectivorous bat shows no melatonin disruption under lights with different spectra

Clocking Epilepsies: A Chronomodulated Strategy-Based Therapy for Rhythmic Seizures

New hints for improving sleep: Tea polyphenols mediate gut microbiota to regulate circadian disturbances

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