Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice

Song, Jia; Chu, Shuaishuai; Cui, Yin; Qian, Yue; Li, Xiuxiu; Xu, Fengqin; Shao, Xueming; Ma, Zhengliang; Xia, Tianjiao; Gu, Xiaoping

doi:10.1016/j.expneurol.2018.04.009

Cited by 48 publications

(35 citation statements)

References 42 publications

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“…Similar changes were observed in an epilepsy study as it showed that the sleep‐wake rhythm of rats was shifted forward after induction of epilepsy 30 . In another study, a delay in gross motor activity was present in aged mice after isoflurane exposure, and melatonin was considered the remedy to reverse the circadian rhythm shift 31 …”

Section: Discussionsupporting

confidence: 74%

Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice

Jia

Zhang

et al. 2020

Basic Clin Pharma Tox

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BACKGROUND Sleep disruptions frequently occur in patients after surgery, 1,2 which produces harmful effects on patients, especially the elderly. 3 These effects include increased risk of delirium, 4 enhanced sensitivity to pain, more cardiovascular events and prolonged recovery. 5,6 Post-operative disruptions of sleep and wakefulness include more frequent awakenings, lack of deep, non-rapid eye movement (NREM) sleep, an initial reduction and subsequent rebound increase in rapid eye movement (REM) sleep, daytime sleepiness and circadian rhythm disorders. 7,8 That is, both sleep structure and sleep quality are affected, and these disruptions can last weeks to months. Compared with young people, elderly patients are more prone to develop post-operative sleep disruption. 6 Previously, several studies have supplied evidence that anaesthesia and surgical trauma are associated with post-operative sleep disruption. 6,9 Song et al 10 found that general anaesthesia was an independent risk factor for desynchronization of the circadian time structure and that it could cause post-operative sleep disorders characterized by reduced REM and slow wave sleep. Many neural networks known to contribute to

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Section: Discussionsupporting

confidence: 74%

Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice

Jia

Zhang

et al. 2020

Basic Clin Pharma Tox

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“…For example, it is reported that ~30-50% patients suffer from postoperative cognitive dysfunction after cardiac surgery, and only 45% of them can recover to baseline cognitive function by one year after surgery (3). Isoflurane is a generally used anesthetic that has been reported to induce cognitive dysfunction in patients after surgery (4). Previous studies have provided evidence for neuroinflammation as a key event in the pathogenesis of isoflurane-induced cognitive dysfunction (5).…”

Section: Introductionmentioning

confidence: 99%

Tetramethylpyrazine ameliorates isoflurane‑induced cognitive dysfunction by inhibiting neuroinflammation via miR‑150 in rats

Cui¹,

Zhang²,

Qu³

2020

Exp Ther Med

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Tetramethylpyrazine (TMP) has neuroprotective effects in the pathogenesis of some human diseases, such as Parkinson's disease. The present study aimed to investigate the role of TMP in isoflurane-induced cognitive dysfunction in rats, and further identify the mechanisms involved in the protective effects of TMP. The Morris water maze test was used to evaluate the cognitive function of rats exposed to isoflurane or treated with TMP. ELISA was conducted to evaluate the effects of isoflurane or TMP on neuroinflammation. The expression of microRNA-150 (miR-150) was measured using reverse transcription-quantitative PCR, and the potential target genes of miR-150 were predicted and verified. The impaired cognitive function induced by isoflurane in the rats was significantly ameliorated by treatment with TMP. In addition, TMP treatment in rats attenuated neuroinflammation caused by isoflurane. The expression of miR-150 was inhibited by isoflurane exposure, but was enhanced by TMP treatment in rats. Furthermore, the overexpression of miR-150 alleviated the isoflurane-induced cognitive dysfunction and neuroinflammation, while the neuroprotective effects of TMP were significantly abrogated by the knockdown of miR-150. AKT3 was a direct target of miR-150, and its mRNA expression was significantly decreased by the overexpression of miR-150 in isoflurane-and TMP-treated rats. These results demonstrated the protective effects of TMP against isoflurane-induced cognitive dysfunction, which were achieved by attenuating neuroinflammation via the regulation of the miR-150/AKT3 pathway. In addition, miR-150 may serve as a novel therapeutic target for the alleviation of cognitive dysfunction induced by anesthetics.

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“…In addition, anaesthesia and surgery can delay the secretion of melatonin at night, seriously interfere with the normal circadian rhythm of melatonin, and eventually disrupt the normal sleep cycle of patients [ 138 ]. Furthermore, melatonin can normalize the time shift of the clock gene mRNA peak, enhance the expression of clock gene mRNA, restore the circadian rhythm of resting activity and body temperature in elderly mice, and alleviate isoflurane-induced cognitive impairment [ 139 ].…”

Section: Methodsmentioning

confidence: 99%

Perioperative neurocognitive dysfunction: thinking from the gut?

Yan

et al. 2020

Aging

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With the aging of the world population, and improvements in medical and health technologies, there are increasing numbers of elderly patients undergoing anaesthesia and surgery. Perioperative neurocognitive dysfunction has gradually attracted increasing attention from academics. Very recently, 6 well-known journals jointly recommended that the term perioperative neurocognitive dysfunction (defined according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition) should be adopted to improve the quality and consistency of academic communications. Perioperative neurocognitive dysfunction currently includes preoperatively diagnosed cognitive decline, postoperative delirium, delayed neurocognitive recovery, and postoperative cognitive dysfunction. Increasing evidence shows that the gut microbiota plays a pivotal role in neuropsychiatric diseases, and in central nervous system functions via the microbiota-gut-brain axis. We recently reported that abnormalities in the composition of the gut microbiota might underlie the mechanisms of postoperative cognitive dysfunction and postoperative delirium, suggesting a critical role for the gut microbiota in perioperative neurocognitive dysfunction. This article therefore reviewed recent findings on the linkage between the gut microbiota and the underlying mechanisms of perioperative neurocognitive dysfunction.

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Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice

Cited by 48 publications

References 42 publications

Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice

Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice

Tetramethylpyrazine ameliorates isoflurane‑induced cognitive dysfunction by inhibiting neuroinflammation via miR‑150 in rats

Perioperative neurocognitive dysfunction: thinking from the gut?

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