Circadian rhythm of total urinary hydroxyproline excretion and 3-H hydroxyproline test

Radom, S; Zuławski, M; Dahlig, E.

doi:10.1016/0009-8981(72)90336-1

Cited by 8 publications

(3 citation statements)

References 1 publication

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“…Such an additive effect of calcitonin and the bisphosphonate etidronate has been observed in humans afflicted with Paget's disease (14) and may be relevant in cases when hypercalcemia has to be corrected rapidly. However, our results contradict some results obtained in the rat where resorption was assessed by measuring [3H]TC in 24-h urine and where no additive effects of calcitonin and a bisphosphonate were found (15 humans, indicated by an increased urinary excretion of the markers of bone resorption, hydroxyproline (17), and pyridinium cross-links (18,19,20) during the night. Whether in these subjects the main meal was in the evening and the fluctuation was therefore at least partially food induced is not known.…”

Section: Discussioncontrasting

confidence: 99%

The diurnal rhythm of bone resorption in the rat. Effect of feeding habits and pharmacological inhibitors.

Mühlbauer¹,

Fleisch²

1995

J. Clin. Invest.

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Prevention of low bone mass is important to reducing the incidence of osteoporotic fractures. This paper shows that, in rats, bone mass can be increased by feeding habits per se. Using six-hourly urinary excretion of [3H]tetracycline from prelabeled rats to monitor bone resorption, we previously found a peak of bone resorption following food administration. We now demonstrate that dividing the solid and liquid intake into portions blunts this peak and leads to a decrease in 24-h bone resorption to the level observed in thyroparathyroidectomized animals. Calcium balance increases and, when such feeding schedules are imposed for 30 d, bone mass increases. Dividing the intake is not effective in thyroparathyroidectomized animals, indicating the importance of PTH and/or calcitonin. Administration of calcitonin inhibits practically only the peak of bone resorption, suggesting that it is osteoclast mediated. In contrast, treatment with a bisphosphonate reduces basal bone resorption without a specific effect on the peak, indicating a fundamentally different mechanism of action. This is also supported by the finding that their combined effects are additive. Whether bone mass in humans is also under the control of dietary habits is not known. If so, an increased meal frequency may be used to prevent osteoporosis. (J. Clin. Invest. 1995Invest. . 95:1933Invest. -1940

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Section: Discussioncontrasting

confidence: 99%

The diurnal rhythm of bone resorption in the rat. Effect of feeding habits and pharmacological inhibitors.

Mühlbauer¹,

Fleisch²

1995

J. Clin. Invest.

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“…Similar findings were noted by Cushieri and Felgate (1972). Urinary hydroxyproline is raised in most subjects with overt metastases, irrespective of the primary tumour type (Guzzo et a/., 1969;Cushieri and Felgate, 1972;Radom et al, 1972;Powles et al, 1975). Of greater interest and potential clinical importance, however, has been the observation that a raised OHP/creatinine ratio may exist prior to the overt development of bone secondaries as determined clinically, radiologically, or by scintiscanning.…”

Section: Urinary Hydroxyprolinesupporting

confidence: 63%

“…Several authors have examined the value of OHP/ creatinine ratio output in relation to the biochemical parameters such as the serum level of alkaline phosphatase and urinary calcium output and found it to be significantly better and probably the most sensitive index of bone metastases at present available (Radom et al, 1972). It has, however, the drawback of requiring more than a blood test and is therefore less suited to use in the elderly.…”

Section: Urinary Hydroxyprolinementioning

confidence: 99%

Biochemical Monitoring of Cancer: A Review

1976

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Diurnal variation in serum markers of type I collagen synthesis and degradation in healthy premenopausal women

Hassager

Risteli

et al. 1992

Journal of Bone and Mineral Research

131

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There are several indications that the functions of human osteoblasts and osteoclasts have circadian rhythms with peak activities occurring at night. It is not known, however, whether the principal function of these cells, namely synthesis and degradation of the organic matrix of bone, of which about 90% is type I collagen, also has a circadian rhythm. This was therefore investigated for both the formation of type I collagen and the degradation of type I collagen in bone using two newly developed serum markers: the serum concentration of the carboxy-terminal propeptide of type I procollagen (PICP) as a marker of formation and the serum concentration of the carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) as a marker of degradation. PICP and ICTP were measured by RIA in samples taken every 3 h over a 24 h period in 12 healthy premenopausal women (age 32 +/- 5 years, mean +/- SD). Both PICP (p = 0.003) and ICTP (p = 0.00003) showed a significant circadian rhythm, with about 20% higher values at night than in the afternoon. We conclude that serum markers of both the formation of new type I collagen and the degradation of old type I collagen in bone exhibit a clear circadian rhythm, with increased activity of both osteoblasts and osteoclasts at night. The etiology of this circadian rhythm is still unknown.

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Circadian rhythm of total urinary hydroxyproline excretion and 3-H hydroxyproline test

Cited by 8 publications

References 1 publication

The diurnal rhythm of bone resorption in the rat. Effect of feeding habits and pharmacological inhibitors.

The diurnal rhythm of bone resorption in the rat. Effect of feeding habits and pharmacological inhibitors.

Biochemical Monitoring of Cancer: A Review

Diurnal variation in serum markers of type I collagen synthesis and degradation in healthy premenopausal women

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