Circadian rhythm of catecholamines, cortisol and prolactin is altered in patients with apallic syndrome in comparison with normal volunteers

Ratge, D.; Knoll, E.; Diener, U.; Hadjidimos, A.; Wisser, H.

doi:10.1530/acta.0.1010428

Cited by 19 publications

(11 citation statements)

References 18 publications

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“…Increased cortisol concentrations and an attenuated circadian rhythm have been reported by Okuyama et af. ), Ratge et al (1982) and Sack et al (1983. Nocke-Finck et al (1978) and Ratge et al (1982) even found an absent circadian cortisol rhythm in some of their patients.…”

Section: Discussionmentioning

confidence: 92%

Twenty‐four‐hour Profiles of Growth Hormone, Prolactin and Cortisol in the Chronic Vegetative State

Vogel

Kroll

Fritschka

et al. 1990

Clinical Endocrinology

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SUMMARY The 24‐h profiles of growth hormone (GH), prolactin (PRL) and Cortisol were obtained from 11 patients in the chronic vegetative state in order to gain more insight into the neuroendocrine alterations caused by widespread suprahypo‐thalamic brain damage. Age and sex‐matched normal subjects served as a control group. Patients had fewer high‐amplitude GH peaks (>20 mU/1: 6 peaks/24 h vs 21 peaks/24‐h in controls) and a (non‐significant) tendency towards higher basal GH concentrations. PRL concentrations were higher in patients (296 ± 212 (SD) vs 120±28 mU/1). Cosinor analysis also showed that 24‐h rhythmicity was preserved, but acrophases were more dispersed. A nocturnal PRL acrophase occurred in only three of 11 patients but in 10 of 11 control subjects. The number of PRL peaks was the same in patients and controls. Cortisol concentrations were also higher in patients (298.3 ± 114.6 vs 193.6 ± 97.4 nmol/1) with a preserved circadian rhythm. The acrophases, however, were likewise more dispersed. There was no difference in the number of Cortisol peaks between patients and controls, but the mean peak duration was shorter in patients (75.4 ± 28.1 vs 109.5 ± 28.2 min). The stage of remission was negatively correlated with the 24‐h mean and the mean peak amplitude of PRL. No patient showed a normal organization of sleep stages. On visual analysis there was no apparent association between EEG patterns and hormonal parameters. These results suggest that the endocrine hypothalamus is essentially intact in the chronic vegetative state. The observed changes may be due to an altered input from extrahypothalamic brain structures.

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Section: Discussionmentioning

confidence: 92%

Twenty‐four‐hour Profiles of Growth Hormone, Prolactin and Cortisol in the Chronic Vegetative State

Vogel

Kroll

Fritschka

et al. 1990

Clinical Endocrinology

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“…The values recorded on each day were integrated by planimetry. Blood samples for the determination of plasma catecholamines 12 and plasma renin activity 13 were withdrawn between 11 a.m. and 2 p.m.…”

Section: Scalementioning

confidence: 99%

Chronic arterial and venous catheterization of conscious, unrestrained rats.

Fejes-Tóth¹,

Náray-Fejes-Tóth²,

Ratge³

et al. 1984

Hypertension

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GEZA FEJES-T6TH, ANIK6 NARAY-FEJES-T6TH, DIETER RATGE, AND JURGEN C. FROLICH SUMMARY A method is described for implanting arterial and venous cannulas in rats that requires only minor surgery. Catheters are introduced into the abdominal aorta through the ventral tail artery and into the vena cava through a lateral tail vein. The wounds are covered with an acrylic cuff and the catheters are brought out through a stainless steel spiral connected to the cuff and then attached to top of a metabolism cage used to house the rat. This method makes possible continuous access to the catheters in undisturbed, mobile animals. Using this model we compared mean arterial pressure, heart rate, plasma renin activity, and plasma catecholamine levels in freely moving Long-Evans rats and in Brattleboro homozygous rats. (Hypertension 6: 926-930, 1984) KEY WORDS • chronic vascular catheters • blood pressure • Brattleboro rat • plasma renin activity • plasma catecholamines A LTHOUGH most of our present knowledge in animal physiology comes from experiments performed on anesthetized animals or from in vitro studies, the utility of these preparations is often curtailed when highly complex neural or hormonal regulatory mechanisms are investigated. Basal secretion rates and plasma levels of most hormones are drastically influenced by anesthesia and surgical trauma,'" 3 and even simple handling of animals may have profound effects. The effect of general anesthesia on mean arterial pressure (MAP) and cardiovascular control mechanisms is well established, 6 and even kidney function, which was generally regarded to be immune to these interventions, has recently been found to be markedly depressed during and following general anesthesia and surgical stress.7 " 9 Although methods have been developed to study larger laboratory animals under relatively unstressed conditions, such methods have not been generally adopted for the rat.We describe a simple, chronic rat preparation that makes possible intravenous infusions, continuous monitoring of MAP and heart rate (HR), and repeated blood sampling in freely moving animals. Since vasopressin has been suggested to be involved in the regulation of blood pressure, 10 we have also compared the resting MAP of the Brattleboro rat suffering from hereditary diabetes insipidus" with the blood pressure of the normal Long-Evans rat from which the Brattleboro rat has been derived. Materials and Methods A slightly conic protecting cuff with a bulging middle portion was made from a rod of plexiglass on a lathe (Figure 1). A hole was bored into the middle portion of the cuff, and perpendicular to it a longitudinal slit was made. A 3 mm diameter stainless steel spiral, which had been previously stretched to 105% of its original length to render it more flexible, was glued into the cuff with epoxy. The first few centimeters of the spiral were fortified by surrounding it with a 4 mm diameter spiral. Two 55 cm long PE-10 tubings (ClayAdams, Parsippany, New Jersey) were fed through the spiral, the proximal ends of th...

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“…Serum concentration and urinary excretion of cortisol show a very clear and stable circadian rhythm. This also applies to the serum concentration and urinary excretion of the catecholamines epinephrine and norepinephrine, but not to dopamine (2).…”

Section: Introductionmentioning

confidence: 99%

Influence of Food Intake on Concentrations of Plasma Catecholamines and Cortisol

Knoll¹,

Müller²,

Ratge³

et al. 1984

Clinical Chemistry and Laboratory Medicine

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Circadian rhythm of catecholamines, cortisol and prolactin is altered in patients with apallic syndrome in comparison with normal volunteers

Cited by 19 publications

References 18 publications

Twenty‐four‐hour Profiles of Growth Hormone, Prolactin and Cortisol in the Chronic Vegetative State

Twenty‐four‐hour Profiles of Growth Hormone, Prolactin and Cortisol in the Chronic Vegetative State

Chronic arterial and venous catheterization of conscious, unrestrained rats.

Influence of Food Intake on Concentrations of Plasma Catecholamines and Cortisol

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