Circadian Rhythm of Autonomic Cardiovascular Control During Mars500 Simulated Mission to Mars

Vigo, Daniel Eduardo; Tuerlinckx, Francis; Ogrinz, Barbara; Wan, Li; Simonelli, Guido; Bersenev, E. Yu.; Bergh, Omer Van den; Aubert, André

doi:10.3357/asem.3612.2013

Cited by 41 publications

(35 citation statements)

References 21 publications

(26 reference statements)

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“…Physical activity decreased during isolation and resulted in impaired neuromuscular performance mainly in the lower limbs (7). Moreover, the circadian heart rate and HRV were significantly disrupted and circadian misalignment was observed due to the lack of natural daylight (62). A well-balanced day/night cycle, however, with adequate sleep/rest and activity phases properly synchronized to the circadian rhythm is critical for keeping the crew healthy (5,6,9).…”

Section: Laboratory-based Spaceflight Simulationsmentioning

confidence: 99%

Effects of isolation and confinement on humans-implications for manned space explorations

Pagel¹,

Choukèr²

2016

Journal of Applied Physiology

104

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Human psychology and physiology are significantly altered by isolation and confinement. In light of planned exploration class interplanetary missions, the related adverse effects on the human body need to be explored and defined as they have a large impact on a mission's success. Terrestrial space analogs offer an excellent controlled environment to study some of these stressors during a space mission in isolation without the complex environment of the International Space Station. Participants subjected to these space analog conditions can encounter typical symptoms ranging from neurocognitive changes, fatigue, misaligned circadian rhythm, sleep disorders, altered stress hormone levels, and immune modulatory changes. This review focuses on both the psychological and the physiological responses observed in participants of long-duration spaceflight analog studies, such as Mars500 or Antarctic winter-over. They provide important insight into similarities and differences encountered in each simulated setting. The identification of adverse effects from confinement allows not only the crew to better prepare for but also to design feasible countermeasures that will help support space travelers during exploration class missions in the future.

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Section: Laboratory-based Spaceflight Simulationsmentioning

confidence: 99%

Effects of isolation and confinement on humans-implications for manned space explorations

Pagel¹,

Choukèr²

2016

Journal of Applied Physiology

104

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“…This unique experiment provided an outstanding opportunity to evaluate the changes in psychological and physiological adaptation over 520 days of coninement [1], by simulating the crew's coninement, cohabitation and communication to Earth, along with the speciic activities and workload taking place in these conditions [2]. Previous reports on the Mars-500 project described mood and sleep-wake changes [3,4], as well as modiications of muscle strength [5] and autonomic nervous system function [6] and of some circulating biomarker levels associated with chronic environmental stress [3]. The potential body composition and metabolic changes associated with these psychological and physiological features have, however, not yet been reported.…”

Section: U N C O R R E C T E D P R O O F Introductionmentioning

confidence: 99%

Body composition and metabolic changes during a 520-day mission simulation to Mars

Strollo

Macchi

Eberini

et al. 2018

J Endocrinol Invest

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“…58,59 Bed rest simulations of relevant durations, 60 and dry immersion simulations (up to 2 weeks). 61 …”

Section: What Are the In-flight Alterations In Cardiovascular Structumentioning

confidence: 99%

Towards human exploration of space: the THESEUS review series on cardiovascular, respiratory, and renal research priorities

et al. 2016

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International audienceThe THESEUS project (Towards Human Exploration of Space: aEUropean Strategy) was initiated within the seventh FrameworkProgramme by the European Commission. This project aimed toprovide a cross-cutting, life science-based roadmap for Europe’sstrategy towards human exploration of space, especially for deepspace missions and its relevance to applications on Earth. Toaddress these challenges, relevance of space research on thecardiovascular system, the lungs and kidneys, was discussed in anexpert group and its principal conclusions will be presented in thisarticle

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Circadian Rhythm of Autonomic Cardiovascular Control During Mars500 Simulated Mission to Mars

Abstract: Data revealed diminished amplitude of the rest-activity pattern of the autonomic nervous system parasympathetic function. Reduced daylight exposure and mood changes could account for this observation.

Cited by 41 publications

References 21 publications

Effects of isolation and confinement on humans-implications for manned space explorations

Effects of isolation and confinement on humans-implications for manned space explorations

Body composition and metabolic changes during a 520-day mission simulation to Mars

Towards human exploration of space: the THESEUS review series on cardiovascular, respiratory, and renal research priorities

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