Circadian rhythm in rat brain opiate receptor

Wirz‐Justice, Anna; Kafka, Marian S.

doi:10.1016/0304-3940(81)90055-0

Cited by 110 publications

(36 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the number of -opioid receptors was significantly larger in brainstem prepared at 9:00 PM than at 9:00 AM. This result is supported by a previous chronopharmacological finding on -opioid receptor (Naber et al, 1981). Thus, the 24-h rhythms in endogenous opioid activity and -opioid receptor expression seem to be mainly responsible for the rhythm in the basal pain sensitivity of mice in nondrugged state.…”

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

“…The time-dependent difference in the analgesic effect after chronic treatment or recovery from tolerance is closely related to that in the expression of -opioid receptor. The present study suggests that 24-h rhythm of morphine analgesic effect is consistent with 24-h rhythm of -opioid receptor expression.A large number of physiological rhythms are controlled by the central nervous system, hormone secretion, and so on (Thomson et al, 1980;Naber et al, 1981). Also, many drugs vary in potency and/or toxicity according to the time in the 24-h cycle when they have been administered (Walker and…”

mentioning

confidence: 99%

“…A large number of physiological rhythms are controlled by the central nervous system, hormone secretion, and so on (Thomson et al, 1980;Naber et al, 1981). Also, many drugs vary in potency and/or toxicity according to the time in the 24-h cycle when they have been administered (Walker and Owasoyo, 1974;Ohdo et al, 1988Ohdo et al, , 1991Ohdo et al, , 1996Ohdo et al, , 1997Ohdo et al, , 1998Ohdo et al, , 2001Koyanagi and Ohdo, 2002).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Chronopharmacology of Analgesic Effect and Its Tolerance Induced by Morphine in Mice

Yoshida

Ohdo²,

Takane

et al. 2003

J Pharmacol Exp Ther

View full text Add to dashboard Cite

The influence of morphine dosing time on analgesic effect after acute or chronic treatment, recovery of analgesic effect after once developed tolerance, and their pharmacological mechanisms were investigated in ICR male mice under a 12-h light/ dark cycle (light on from 7:00 AM to 7:00 PM). There was a significant 24-h rhythm in the latency of thermal response at 30 min after morphine injection. The analgesic effect was significantly greater at the dark phase than at the light phase. The rhythmic pattern resembled overall the rhythm occurring in the latency of thermal response under nondrugged state. The absolute value of morphine analgesic effect (the real time spent on the hot-plate) on days 1 and 2 after morphine daily injection was significantly larger after morphine injection at 9:00 PM than after saline injection at 9:00 PM or after morphine injection at 9:00 AM. The recovery from tolerance of analgesic effect was significantly faster at the dark phase than at the light phase. The time-dependent difference in the analgesic effect after chronic treatment or recovery from tolerance is closely related to that in the expression of -opioid receptor. The present study suggests that 24-h rhythm of morphine analgesic effect is consistent with 24-h rhythm of -opioid receptor expression.A large number of physiological rhythms are controlled by the central nervous system, hormone secretion, and so on (Thomson et al., 1980;Naber et al., 1981). Also, many drugs vary in potency and/or toxicity according to the time in the 24-h cycle when they have been administered (Walker and

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Chronopharmacology of Analgesic Effect and Its Tolerance Induced by Morphine in Mice

Yoshida

Ohdo²,

Takane

et al. 2003

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…The analgesic effect of morphine also varies according to the administration time (13,14). The dosing timedependent difference in the analgesic effect is associated with 24-h variation in µ-opioid receptor function in the brainstem which is regulated by endogenous glucocorticoid hormone (14,15).…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid Is Involved in Food-Entrainable Rhythm of μ-Opioid Receptor Expression in Mouse Brainstem and Analgesic Effect of Morphine

et al. 2006

View full text Add to dashboard Cite

Abstract. The repeated manipulation of feeding schedule has a marked influence on the chronopharmaological aspects of many drugs. In this study, we investigated the role of endogenous glucocorticoid in the mechanism by which restricting the feeding time modulates the analgesic effect of morphine. Male ICR mice were housed under a light-dark cycle (light on from 07:00 to 19:00) with food and water ad libitum or under repeated time-restricted feeding (feeding time from 09:00 to 17:00) for 2 weeks before the experiment. Under the ad libitum feeding, mRNA levels of µ-opioid receptor and its binding capacity in mouse brainstem increased around the early dark phase, following the 24-h variation in circulating glucocorticoid levels. As a consequence, potent analgesic effects of morphine were observed in mice injected with the drug during the dark phase. Daily restricted feeding modulated the time-dependency of µ-opioid receptor function, accompanied by the alteration of the rhythm in circulating glucocorticoid levels. Under the time-restricted feeding, potent analgesic effects of morphine were found in mice injected with the drug during the light phase. Because the manipulation of feeding schedule was unable to produce the food-entrainable rhythm in the expression of µ-opioid receptor in the brainstem of adrenalectomized mice, endogenous rhythm of glucocorticoid secretion seems to be involved in the mechanism by which the time-restricted feeding modulates the analgesic effects of morphine.

show abstract

Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth

Neale

Thapar

et al. 2007

American J of Med Genetics Pt B

View full text Add to dashboard Cite

Season of birth (SOB) has been associated with attention deficit hyperactivity disorder (ADHD) in two existing studies. One further study reported an interaction between SOB and genotypes of the dopamine D4 receptor (DRD4) gene. It is important that these findings are further investigated to confirm or refute the findings. In this study, we investigated the SOB association with ADHD in four independent samples collected for molecular genetic studies of ADHD and found a small but significant increase in summer births compared to a large population control dataset. We also observed a significant association with the 7-repeat allele of the DRD4 gene variable number tandem repeat polymorphism in exon three with probands born in the winter season, with no significant differential transmission of this allele between summer and winter seasons. Preferential transmission of the 2-repeat allele to ADHD probands occurred in those who were born during the summer season, but did not surpass significance for association, even though the difference in transmission between the two seasons was nominally significant. However, following adjustment for multiple testing of alleles none of the SOB effects remained significant. We conclude that the DRD4 7-repeat allele is associated with ADHD but there is no association or interaction with SOB for increased risk for ADHD. Our findings suggest that we can refute a possible effect of SOB for ADHD.

show abstract

Circadian rhythm in rat brain opiate receptor

Cited by 110 publications

References 20 publications

Chronopharmacology of Analgesic Effect and Its Tolerance Induced by Morphine in Mice

Chronopharmacology of Analgesic Effect and Its Tolerance Induced by Morphine in Mice

Glucocorticoid Is Involved in Food-Entrainable Rhythm of μ-Opioid Receptor Expression in Mouse Brainstem and Analgesic Effect of Morphine

Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth

Contact Info

Product

Resources

About