Circadian rhythm–dependent induction of hepatic lipogenic gene expression in rats fed a high-sucrose diet

Sun, Siyuan; Hanzawa, Fumiaki; Kim, Daeun; Umeki, Miki; Nakajima, Shinya; Sakai, Kumiko; Ikeda, Shoichiro; Mochizuki, Seibu; Oda, Hiroaki

doi:10.1074/jbc.ra119.010328

Cited by 20 publications

(9 citation statements)

References 54 publications

(64 reference statements)

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“…In contrast to the findings described above, four weeks of a high‐sucrose diet did not alter hepatic clock gene expression in rats (Sun et al , 2019a). Conversely, it modestly changed the amplitude and rhythm of gene expression related to fructolysis and de novo lipogenesis , leading to fatty liver and the development of hyperlipidemia.…”

Section: Introductioncontrasting

confidence: 97%

“…Conversely, it modestly changed the amplitude and rhythm of gene expression related to fructolysis and de novo lipogenesis , leading to fatty liver and the development of hyperlipidemia. Hepatic phosphate levels were reduced under high‐sucrose diet, indicating lower ATP levels (Sun et al , 2019a). Since ATP is a putative mRNA stabilizer (Chen et al , 2007), these reports imply that variations in ATP‐dependent RNA stability contribute to the high‐sucrose‐induced amplitude enhancement of lipogenic enzyme mRNA in the liver.…”

Section: Introductionmentioning

confidence: 99%

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Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming

Sassone–Corsi

2022

EMBO Reports

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Food intake profoundly affects systemic physiology. A large body of evidence has indicated a link between food intake and circadian rhythms, and ~24-h cycles are deemed essential for adapting internal homeostasis to the external environment. Circadian rhythms are controlled by the biological clock, a molecular system remarkably conserved throughout evolution. The circadian clock controls the cyclic expression of numerous genes, a regulatory program common to all mammalian cells, which may lead to various metabolic and physiological disturbances if hindered. Although the circadian clock regulates multiple metabolic pathways, metabolic states also provide feedback on the molecular clock. Therefore, a remarkable feature is reprogramming by nutritional challenges, such as a high-fat diet, fasting, ketogenic diet, and caloric restriction. In addition, various factors such as energy balance, histone modifications, and nuclear receptor activity are involved in the remodeling of the clock. Herein, we review the interaction of dietary components with the circadian system and illustrate the relationships linking the molecular clock to metabolism and critical roles in the remodeling process.

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Section: Introductioncontrasting

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming

Sassone–Corsi

2022

EMBO Reports

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“…[43] The observed diurnal pattern in hepatic DNL is in accordance with previous study demonstrating that HFr diet causes circadian alterations in lipogenic gene expression in rat liver, with maximum amplitude at the beginning of light phase. [44] Similar observa-tions were reported in humans by Hudgins et al, who found that subjects with a "diurnal" pattern are characterized by a low fasting fDNL followed by a late evening peak and return to low levels the next morning. [35] A novelty of our study is the observation that HFr influenced lipogenesis in the kidney by increasing: 1) the percent of palmitate in the total renal fat; 2) DNPalm content in IRTG; 3) renal FAS gene expression.…”

Section: Discussionsupporting

confidence: 70%

Chronic Stress Potentiates High Fructose–Induced Lipogenesis in Rat Liver and Kidney

Milutinović

Brkljačić

Teofilović

et al. 2020

Molecular Nutrition Food Res

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Scope Intake of fructose‐sweetened beverages and chronic stress (CS) both increase risk of cardiometabolic diseases. The aim is to investigate whether these factors synergistically perturb lipid metabolism in rat liver and kidney. Methods and results Fractional de novo lipogenesis (fDNL), intrahepatic‐ and intrarenal‐triglycerides (IHTG and IRTG), de novo palmitate (DNPalm) content, FA composition, VLDL‐TGs kinetics, and key metabolic gene expression at the end of the feeding and non‐feeding phases in rats exposed to standard chow diet, chow diet + CS, 20% liquid high‐fructose supplementation (HFr), or HFr+CS are measured. HFr induces hypertriglyceridemia, up‐regulates fructose‐metabolism and gluconeogenic enzymes, increases IHTG and DNPalm content in IHTG and IRTG, and augments fDNL at the end of the feeding phase. These changes are diminished after the non‐feeding phase. CS does not exert such effects, but when combined with HFr, it reduces IHTG and visceral adiposity, enhances lipogenic gene expression and fDNL, and increases VLDL‐DNPalm secretion. Conclusion Liquid high‐fructose supplementation increases IHTG and VLDL‐TG secretion after the feeding phase, the latter being the result of stimulated hepatic and renal DNL. Chronic stress potentiates the effects of high fructose on fDNL and export of newly synthesized VLDL‐TGs, and decreases fructose‐induced intrahepatic TG accumulation after the feeding phase.

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“…The coordinated regulation of the circadian clock and endocrine system on the physiology and behavior is a fascinating and confusing subject that has attracted much research attention. Studies have shown that the circadian clock regulated the organism’s metabolism and endocrine systems, so that the body could adapt to environmental temperature, light, and diet [ 1 , 2 , 3 ]. This is mediated by a series of transcription factors through the mutual regulation of the transcription-translation feedback loop (TTFL) and endocrine hormones [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Circadian Clock Gene Period Contributes to Diapause via GABAeric-Diapause Hormone Pathway in Bombyx mori

Cui

Qiu

Dai

et al. 2021

Biology

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Diapause is a developmental transition in insects based on seasonal adaptation to adversity; it is regulated by a circadian clock system and the endocrine system. However, the molecular node and its mechanism underlying the effects of these systems are still unclear. Here, a mutant of Bombyx mori with the circadian clock gene Period (Per) knocked out was constructed, which dramatically changed the classic diapause-destined pathway. Per-knockout silkworms powerfully attenuated, but could not completely block, the predetermined effects of temperature and photoperiod on diapause determination, and this effect depended on the diapause hormone (DH) pathway. The impaired transcription-translation feedback loop of the circadian clock system lacking the Per gene caused direct up-regulation of the expression of GRD, a receptor of γ-aminobutyric acid (GABA), by changing expression level of Cycle. The synthesis of GABA in the tissue complex of brain-suboesophageal ganglion then increased and restricted the decomposition, which continuously promoted the GABAergic signal to play a role, and finally inhibiting (delaying) the release of DH to the hemolymph, and reducing the diapause-inducing effect of DH. The results provided an example to explain the regulatory mechanism of the circadian clock on endocrine hormones in the silkworm.

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Circadian rhythm–dependent induction of hepatic lipogenic gene expression in rats fed a high-sucrose diet

Cited by 20 publications

References 54 publications

Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming

Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming

Chronic Stress Potentiates High Fructose–Induced Lipogenesis in Rat Liver and Kidney

Circadian Clock Gene Period Contributes to Diapause via GABAeric-Diapause Hormone Pathway in Bombyx mori

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