Circadian rhythm-associated lncRNA RP11-414H17.5 as a key therapeutic target in osteosarcoma affects the tumor immune microenvironment and enhances malignancy
Liangkun Huang,
Wanting Liang,
Wenxiang Cai
et al.
Abstract:Background
It has previously been proven that circadian rhythm disruption is associated with the incidence and deterioration of several tumors, which potentially leads to increased tumor susceptibility and a worse prognosis for tumor-bearing patients. However, their potential role in osteosarcoma has yet to be sufficiently investigated.
Methods
Transcriptomic and clinical data of 84 osteosarcoma samples and 70 normal bone tissue samples were obtain… Show more
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