Circadian rhythm and time-of-day-effects of (anti)oxidant biomarkers for epidemiological studies

Ruskovska, Tatjana; Beekhof, Piet; Velickova, Nevenka; Kamcev, Nikola; Jansen, Eugène

doi:10.1080/10715762.2021.1942464

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…We did not have information on time of day of blood collection, proinflammatory cytokines do exhibit a circadian rhythm [ 47 ], but we were unable to account for this in our analyses which may have influenced our findings. While CRP is not subject to diurnal variation [ 48 ], sleep deprivation and circadian misalignment, which can be common during pregnancy [ 49 ], can influence levels [ 50 ], but we are unable to quantify the impact of these factors on levels and therefore on our conclusions.…”

Section: Discussionmentioning

confidence: 99%

Maternal Inflammatory Biomarkers during Pregnancy and Early Life Neurodevelopment in Offspring: Results from the VDAART Study

Kelly

Lee-Sarwar

Chen

et al. 2022

IJMS

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Maternal infection and stress during the prenatal period have been associated with adverse neurodevelopmental outcomes in offspring, suggesting that biomarkers of increased inflammation in the mothers may associate with poorer developmental outcomes. In 491 mother–child pairs from the Vitamin D Antenatal Asthma Reduction Trial (VDAART), we investigated the association between maternal levels of two inflammatory biomarkers; interleukin-8 (IL-8) and C-Reactive Protein (CRP) during early (10–18 wks) and late (32–38 wks) pregnancy with offspring scores in the five domains of the Ages and Stages Questionnaire, a validated screening tool for assessing early life development. We identified a robust association between early pregnancy IL-8 levels and decreased fine-motor (β: −0.919, 95%CI: −1.425, −0.414, p = 3.9 × 10−4) and problem-solving skills at age two (β: −1.221, 95%CI: −1.904, −0.414, p = 4.9 × 10−4). Associations between IL-8 with other domains of development and those for CRP did not survive correction for multiple testing. Similarly, while there was some evidence that the detrimental effects of early pregnancy IL-8 were strongest in boys and in those who were not breastfed, these interactions were not robust to correction for multiple testing. However, further research is required to determine if other maternal inflammatory biomarkers associate with offspring neurodevelopment and work should continue to focus on the management of factors leading to increases in IL-8 levels in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Maternal Inflammatory Biomarkers during Pregnancy and Early Life Neurodevelopment in Offspring: Results from the VDAART Study

Kelly

Lee-Sarwar

Chen

et al. 2022

IJMS

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“…48 The various biomarkers indicative of oxidative stress and redox status exhibit significant circadian rhythms. 49 Research on healthy volunteers has shown that the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (R-GSSG), and the concentration of glutathione (GSH) are regulated by circadian rhythms. 50 Similarly, circadian rhythm regulation of the balance between oxidation and antioxidants has also been observed in Daphnia pulex.…”

Section: The Role Of Oxidative Stress In the Relationship Between Sle...mentioning

confidence: 99%

A Narrative Review of the Reciprocal Relationship Between Sleep Deprivation and Chronic Pain: The Role of Oxidative Stress

Chen,

Xie,

Liang

et al. 2024

JPR

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Sleep is crucial for human health, insufficient sleep or poor sleep quality may negatively affect sleep function and lead to a state of sleep deprivation. Sleep deprivation can result in various health problems, including chronic pain. The intricate relationship between sleep and pain is complex and intertwined, with daytime pain affecting sleep quality and poor sleep increasing pain intensity. The article first describes the influence of sleep on the onset and development of pain, and then explores the impact of daytime pain intensity on nighttime sleep quality and subsequent pain thresholds. However, the primary emphasis is placed on the pivotal role of oxidative stress in this bidirectional relationship. Although the exact mechanisms underlying sleep and chronic pain are unclear, this review focuses on the role of oxidative stress. Numerous studies on sleep deprivation have demonstrated that it can lead to varying degrees of increased pain sensitivity, while chronic pain leads to sleep deprivation and further exacerbates pain. Further research on the role of oxidative stress in the mechanism of sleep deprivation-induced pain sensitization seems reasonable. This article comprehensively reviews the current research on the interrelationship between sleep deprivation, pain and the crucial role of oxidative stress.

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Chrono-modulated effects of external stressors on oxidative stress and damage in humans: A scoping review on night shift work

Makris,

Heibati,

Narui

2023

Environment International

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Circadian rhythm and time-of-day-effects of (anti)oxidant biomarkers for epidemiological studies

Cited by 4 publications

References 28 publications

Maternal Inflammatory Biomarkers during Pregnancy and Early Life Neurodevelopment in Offspring: Results from the VDAART Study

Maternal Inflammatory Biomarkers during Pregnancy and Early Life Neurodevelopment in Offspring: Results from the VDAART Study

A Narrative Review of the Reciprocal Relationship Between Sleep Deprivation and Chronic Pain: The Role of Oxidative Stress

Chrono-modulated effects of external stressors on oxidative stress and damage in humans: A scoping review on night shift work

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