Circadian rhythm alterations affecting the pathology of neurodegenerative diseases

Abstract

The circadian rhythm is a nearly 24‐h oscillation found in various physiological processes in the human brain and body that is regulated by environmental and genetic factors. It is responsible for maintaining body homeostasis and it is critical for essential functions, such as metabolic regulation and memory consolidation. Dysregulation in the circadian rhythm can negatively impact human health, resulting in cardiovascular and metabolic diseases, psychiatric disorders, and premature death. Emerging evidence points to a relationship between the dysregulation circadian rhythm and neurodegenerative diseases, suggesting that the alterations in circadian function might play crucial roles in the pathogenesis and progression of neurodegenerative diseases. Better understanding this association is of paramount importance to expand the knowledge on the pathophysiology of neurodegenerative diseases, as well as, to provide potential targets for the development of new interventions based on the dysregulation of circadian rhythm. Here we review the latest findings on dysregulation of circadian rhythm alterations in Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, spinocerebellar ataxia and multiple‐system atrophy, focusing on research published in the last 3 years.image

Circadian Gene Variants in Diseases

“…Pathological changes associated with circadian genes have been described in various types of disease, including tumors [ 29 , 30 , 31 ], metabolic diseases [ 32 ], cardiac diseases [ 33 , 34 ], sleep disorders [ 35 ], psychiatric diseases [ 36 ] and neurodegenerative diseases [ 37 ]. This review focuses on the existing knowledge regarding circadian gene SNPs (single-nucleotide polymorphisms) and their association with these diseases.…”