Circadian rest‐activity rhythm is altered in Parkinson's disease patients with hallucinations

Whitehead, Daisy L.; Davies, Ann D. M.; Playfer, Jeremy; Turnbull, Christopher J.

doi:10.1002/mds.22057

Cited by 89 publications

(85 citation statements)

References 35 publications

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“…In order to investigate differences in physical activity between these two subgroups, we measured physical activity using actigraphy. Previous studies have reported the usefulness of standard actigraphy to assess fluctuation of akinesia [23], tremor, motor fluctuation [24], and sleep in PD patients [25,26]. In the present study, measured activity counts in the PD group were higher compared to the MPS-severe group.…”

Section: Discussioncontrasting

confidence: 45%

“…Those subjects with unilateral PD wore monitors on their least affected side. This placement has been shown to better represent whole-body movement [25] and was intended to reduce artifacts such as low level constant activity when writing with the dominant hand or dyskinesias in the most affected arm. At the same time, all participants completed a sleep log for 7 days.…”

Section: Measurement Of Physical Activity Using Actigraphymentioning

confidence: 99%

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Mild parkinsonian signs in a community-dwelling elderly population sample in Japan

Uemura

Wada‐Isoe

Nakashita

et al. 2011

Journal of the Neurological Sciences

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Mild parkinsonian signs (MPS) may represent the mild end of a disease spectrum that spans from normal aging to neurodegenerative diseases. We conducted a population-based study in a rural island town in western Japan, Ama-cho. Participants included 1129 subjects, aged 60 years and older, residing in the town. Participants were classified according to a modified Unified Parkinson's Disease Rating Scale (mUPDRS) score. MPS was determined to be present if any of the following conditions were met: (1) two or more mUPDRS ratings=1 [MPS-mild]; (2) one mUPDRS rating≥2; or (3) mUPDRS rest tremor rating≥1; [(2) and (3): MPS-severe]. Subjects wore a uniaxial accelerometer (Actiwatch), resulting in the measurement of actigraphic activity counts (AC). Of the 804 participants with complete data, 178 subjects (22.1%) were classified as demonstrating MPS. AC was significantly lower in the MPS-severe group compared with both the CTL and the MPS-mild groups. Diagnostic sensitivity for MPS-severe became 100% when we adopted a cutoff point of low physical activity, as measured by actigraphy, combined with the presence of subjective depression. We established the prevalence of MPS in a community-dwelling elderly population sample in Japan. Actigraphy may be a useful objective tool for screening MPS-severe.

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Section: Discussioncontrasting

confidence: 45%

Section: Measurement Of Physical Activity Using Actigraphymentioning

confidence: 99%

Mild parkinsonian signs in a community-dwelling elderly population sample in Japan

Uemura

Wada‐Isoe

Nakashita

et al. 2011

Journal of the Neurological Sciences

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“…Previous studies have evidenced a number of circadian rhythm alterations in PD patients (Ferreira et al, 2006;Garcia-Borreguero et al, 2003;Lees et al, 1988;van Hilten et al, 1993;Whitehead et al, 2008;Willis, 2008b), in line with the changes observed in a number of circadian rhythm parameters in different experimental PD models, including the 6-OHDA and the MPTP animal models (Almirall et al, 2001;Ben et al, 1999;Ben & Bruguerolle, 2000). In this study, we assessed whether rotenone-induced parkinsonism is associated with alterations of circadian rhythms.…”

Section: Discussionmentioning

confidence: 63%

“…PD patients often exhibit sleep disorders, such as excessive daytime somnolence and nighttime sleep fragmentation (Ferreira et al, 2006;Garcia-Borreguero et al, 2003;Lees et al, 1988;van Hilten et al, 1993). Actigraphy studies show increased levels of nocturnal motor activity and an increased proportion of time with movement in PD patients (van Hilten et al, 1994), which suggests a more disturbed sleep as well as a lower amplitude rest-activity rhythm with increased intradaily variability as compared to healthy adults (Whitehead et al, 2008). Moreover, PD patients exhibit alterations in various circadian patterns, such as in melatonin (Bordet et al, 2003) and cortisol (Hartmann et al, 1997) secretion, core body temperature (Bordet et al, 2003;Pierangeli et al, 2001), and heart rate variability (Pursiainen et al, 2002), among others.…”

Section: Introductionmentioning

confidence: 96%

Circadian Dysfunction in a Rotenone-Induced Parkinsonian Rodent Model

Lax

Esquiva

Esteve-Rudd

et al. 2012

Chronobiology International

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Parkinson's disease (PD) is a neurodegenerative disorder that also involves circadian rhythm alterations. Modifications of circadian rhythm parameters have been shown to occur in both PD patients and toxin-induced PD animal models. In the latter case, rotenone, a potent inhibitor of mitochondrial complex I (nicotinamide adenine dinucleotide [NADH]-quinone reductase), has been used to elicit degeneration of dopaminergic neurons and development of parkinsonian syndrome. The present work addresses alterations induced by rotenone on both locomotor and body temperature circadian rhythms in rats. Rotenone-treated rats exhibited abnormalities in equilibrium, postural instability, and involuntary movements. Long-term subcutaneous administration of rotenone significantly reduced mean daily locomotor activity in most animals. During rotenone administration, mean body temperatures (BTs) and BT rhythm amplitudes were significantly lower than those observed in the control group. After long-term rotenone administration, the circadian rhythms of both locomotor activity (LA) and BT displayed decreased amplitudes, lower interdaily phase stability, and higher rhythm fragmentation, as compared to the control rats. The magnitude of the LA and BT circadian rhythm alterations induced by rotenone positively correlated with degree of motor impairment. These results indicate that rotenone induces circadian dysfunction in rats through some of the same mechanisms as those responsible for the development of motor disturbances.

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“…A number of studies found an association between visual hallucinations and RBD, 16,21,36,37 and in one study RBD was a predictor of future psychosis. 13 Additionally, compared to those without hallucinations, PD subjects with hallucinations are more likely to have daytime somnolence, 7 severe sleep fragmentation, 37,38 and vivid dreams. 37,39 Recognition of sleepwake dysregulation in PD with hallucinations led to the hypothesis that hallucinations were caused by intrusion of dream imagery into wakefulness.…”

Section: Sleep Disorders and Autonomic Dysfunctionmentioning

confidence: 99%

Risk Factors for Psychosis in Parkinson’s Disease

Barrett

2017

US Endocrinology

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Psychosis is a characteristic neuropsychiatric symptom of Parkinson's disease (PD) that is common and associated with worse outcomes. The purpose of this article is to review identified risk factors for visual hallucinations in PD, the most common manifestation of psychosis. With the possible exception of dopamine agonists, antiparkinsonian medications are only considered modifiers of psychosis in PD. Dementia in PD has consistently been shown to be associated with psychosis, and executive dysfunction and impairment in visual processing appear to play a role in its pathogenesis. The association of psychosis with disorders of sleep-wake dysregulation and autonomic dysfunction supports the involvement of brainstem dysfunction in PD psychosis. Despite many studies evaluating genetic risk factors for hallucinations, GBA mutations are the only variants consistently reported to be associated with an increased risk of hallucinations in PD. Lastly, psychosis in PD is associated with a more severe disease burden, both related and unrelated to PD pathology. Any explanatory model of psychosis in PD must incorporate pharmacological, neuroanatomic, pathological, and genetic factors before there can be a complete understanding of this common and disabling neuropsychiatric symptom. KeywordsParkinson's disease, psychosis, hallucinations, risk factor, dementia, rapid eye movement (REM) sleep behavior disorder Authorship: All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship of this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval to the version to be published.Open Access: This article is published under the Creative Commons Attribution Noncommercial License, which permits any non-commercial use, distribution, adaptation and reproduction provided the original author(s) and source are given appropriate credit. had minor hallucinations prior to PD motor symptom onset.3 In addition to being common, psychosis is also associated with worse outcomes: increased institutionalization, 4 decreased quality of life, 5 and increased mortality. Considering its prevalence and association with worse outcomes, many studies have sought to identify risk factors for psychosis, specifically visual hallucinations. These efforts have contributed to an improved understanding of this disabling neuropsychiatric symptom. Some risk factors, i.e. cognitive impairment and rapid eye movement (REM) sleep behavior disorder (RBD), may be integral to the mechanism by which psychotic symptoms emerge and have contributed to development of explanatory models of psychotic symptoms in PD. Other risk factors likely represent correlations arising from concomitant pathology in areas not involved in psychosis but occurring at a similar disease stage. Lastly, multiple studies have helped to clarify the relationship between antiparkinsonian medications, especially dopaminergic medications, and psychosis in PD.The purpose of this article is to review risk factors fo...

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Circadian rest‐activity rhythm is altered in Parkinson's disease patients with hallucinations

Cited by 89 publications

References 35 publications

Mild parkinsonian signs in a community-dwelling elderly population sample in Japan

Mild parkinsonian signs in a community-dwelling elderly population sample in Japan

Circadian Dysfunction in a Rotenone-Induced Parkinsonian Rodent Model

Risk Factors for Psychosis in Parkinson’s Disease

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