Circadian Regulation of <i>nocturnin</i> Transcription by Phosphorylated CREB in <i>Xenopus</i> Retinal Photoreceptor Cells

Liu, Xiaorong; Green, Carla B.

doi:10.1128/mcb.22.21.7501-7511.2002

Cited by 24 publications

(19 citation statements)

References 75 publications

(92 reference statements)

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“…6). These results are consistent with studies showing circadian control of cAMP levels in chick photoreceptors and pinealocytes (Nikaido and Takahashi, 1998;Ivanova and Iuvone, 2003) and of phospho-cAMP response element-binding protein levels in Xenopus photoreceptors (Liu and Green, 2002), all of which are high at night.…”

Section: Discussionsupporting

confidence: 81%

Gating of the cAMP Signaling Cascade and Melatonin Synthesis by the Circadian Clock in Mammalian Retina

Fukuhara¹,

Liu²,

Ivanova³

et al. 2004

J. Neurosci.

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Melatonin is synthesized in retinal photoreceptor cells and acts as a neuromodulator imparting photoperiodic information to the retina. The synthesis of melatonin is controlled by an ocular circadian clock and by light in a finely tuned mechanism that ensures that melatonin is synthesized and acts only at night in darkness. Here we report that the circadian clock gates melatonin synthesis in part by regulating the expression of the type 1 adenylyl cyclase (AC1) and the synthesis of cAMP in photoreceptor cells. This gating is effected through E-box-mediated transcriptional activation of the AC1 gene, which undergoes robust daily fluctuations that persist in constant illumination. The circadian control of the cAMP signaling cascade indicates that the clock has a more general and profound impact on retinal functions than previously thought. In addition, rhythmic control of AC1 expression was observed in other parts of the central circadian axis, the suprachiasmatic nucleus and pineal gland, but not in other brain areas examined. Thus, clock control of the cAMP signaling cascade may play a central role in the integration of circadian signals that control physiology and behavior.

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Section: Discussionsupporting

confidence: 81%

Gating of the cAMP Signaling Cascade and Melatonin Synthesis by the Circadian Clock in Mammalian Retina

Fukuhara¹,

Liu²,

Ivanova³

et al. 2004

J. Neurosci.

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“…Digoxigenin-labeled antisense T7 and sense T3 probes (Roche, Indianapolis, IN) were prepared, and in situ hybridization was performed (Liu and Green, 2002). Peroxidase-conjugated anti-digoxigenin-peroxidase (1:500; Roche) was used to detect hybridized cRNA probes.…”

Section: Methodsmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor and TrkB Modulate Visual Experience-Dependent Refinement of Neuronal Pathways in Retina

et al. 2007

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Sensory experience refines neuronal structure and functionality. The visual system has proved to be a productive model system to study this plasticity. In the neonatal retina, the dendritic arbors of a large proportion of ganglion cells are diffuse in the inner plexiform layer. With maturation, many of these arbors become monolaminated. Visual deprivation suppresses this remodeling. Little is known of the molecular mechanisms controlling maturational and experience-dependent refinement. Here, we tested the hypothesis that brainderived neurotrophic factor (BDNF), which is known to regulate dendritic branching and synaptic function in the brain, modulates the developmental and visual experience-dependent refinement of retinal ganglion cells. We used a transgenic mouse line, in which a small number of ganglion cells were labeled with yellow fluorescence protein, to delineate their dendritic structure in vivo. We found that transgenic overexpression of BDNF accelerated the laminar refinement of ganglion cell dendrites, whereas decreased TrkB expression or retina-specific deletion of TrkB, the cognate receptor for BDNF, retarded it. BDNF-TrkB signaling regulated the maturational formation of new branches in ON but not the bilaminated ON-OFF ganglion cells. Furthermore, BDNF overexpression overrides the requirement for visual inputs to stimulate laminar refinement and dendritic branching of ganglion cells. These experiments reveal a previously unrecognized action of BDNF and TrkB in controlling cell-specific, experience-dependent remodeling of neuronal structures in the visual system.

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“…VGLUT2 full-length cDNA was used for in situ hybridization (Fremeau et al, 2001). Digoxigenin-labeled antisense T7 and sense T3 probes (Roche, Palo Alto, CA) were prepared and applied as described previously (Liu and Green, 2002). Peroxidase-conjugated antidigoxigenin peroxidase (1:500; Roche) was used to detect hybridized cRNA probes.…”

Section: Methodsmentioning

confidence: 99%

Vesicular Glutamate Transporter 1 Is Required for Photoreceptor Synaptic Signaling But Not For Intrinsic Visual Functions

et al. 2007

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Glutamatergic neurotransmission requires vesicular glutamate transporters (VGLUTs) to sequester glutamate into synaptic vesicles. Generally, VGLUT1 and VGLUT2 isoforms show complementary expression in the CNS and retina. However, little is known about whether isoform-specific expression serves distinct pathways and physiological functions. Here, by examining visual functions in VGLUT1-null mice, we demonstrate that visual signaling from photoreceptors to retinal output neurons requires VGLUT1. However, photoentrainment and pupillary light responses are preserved. We provide evidence that melanopsin-containing, intrinsically photosensitive retinal ganglion cells (RGCs), signaling via VGLUT2 pathways, support these non-image-forming functions. We conclude that VGLUT1 is essential for transmitting visual signals from photoreceptors to second-and third-order neurons, but VGLUT1 is not necessary for intrinsic visual functions. Furthermore, melanopsin and VGLUT2 expression in a subset of RGCs immediately after birth strongly supports the idea that intrinsic vision can function well before rod-and cone-mediated signaling has matured.

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Circadian Regulation of nocturnin Transcription by Phosphorylated CREB in Xenopus Retinal Photoreceptor Cells

Cited by 24 publications

References 75 publications

Gating of the cAMP Signaling Cascade and Melatonin Synthesis by the Circadian Clock in Mammalian Retina

Gating of the cAMP Signaling Cascade and Melatonin Synthesis by the Circadian Clock in Mammalian Retina

Brain-Derived Neurotrophic Factor and TrkB Modulate Visual Experience-Dependent Refinement of Neuronal Pathways in Retina

Vesicular Glutamate Transporter 1 Is Required for Photoreceptor Synaptic Signaling But Not For Intrinsic Visual Functions

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